{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12684","protein_label":"Exodeoxyribonuclease 8","reviewed":true,"short_name":"DUF3799","source_category":"function/molecular_function/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/molecular_function/go/double-stranded-dna-5-3-dna-exonuclease-activity-go0051908.yaml","source_record_id":"GO:0051908","source_record_label":"double-stranded DNA 5'-3' DNA exonuclease activity","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P15032","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12684","protein_label":"Exodeoxyribonuclease 8","reviewed":true,"short_name":"DUF3799","source_category":"function/protein_family/ncbifam","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/protein_family/ncbifam/exodeoxyribonuclease-viii-nf007259.yaml","source_record_id":"NCBIfam:NF007259","source_record_label":"exodeoxyribonuclease VIII","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P15032","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12684","protein_label":"Exodeoxyribonuclease 8","reviewed":true,"short_name":"DUF3799","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/putative-exodeoxyribonuclease-8-pddexk-like-domain-ipr024432.yaml","source_record_id":"InterPro:IPR024432","source_record_label":"Putative exodeoxyribonuclease 8, PDDEXK-like domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P15032","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF12684","protein_label":"","reviewed":null,"short_name":"DUF3799","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/putative-exodeoxyribonuclease-8-pddexk-like-domain-ipr024432.yaml","source_record_id":"InterPro:IPR024432","source_record_label":"Putative exodeoxyribonuclease 8, PDDEXK-like domain","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12684","protein_label":"Exodeoxyribonuclease 8","reviewed":true,"short_name":"DUF3799","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf3799-pf12684.yaml","source_record_id":"Pfam:PF12684","source_record_label":"PDDEXK-like domain of unknown function (DUF3799)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P15032","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF12684","protein_label":"","reviewed":null,"short_name":"DUF3799","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf3799-pf12684.yaml","source_record_id":"Pfam:PF12684","source_record_label":"PDDEXK-like domain of unknown function (DUF3799)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF12684","protein_label":"Exodeoxyribonuclease 8","reviewed":true,"short_name":"DUF3799","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/exonuc-viii-pf06630.yaml","source_record_id":"Pfam:PF06630","source_record_label":"Enterobacterial exodeoxyribonuclease VIII","source_section":"canonical_examples","taxon_id":"NCBITaxon:83333","taxon_label":"Escherichia coli (strain K12)","uniprot_accession":"P15032","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":747,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":1,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":5},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 265 and 420 amino acids in length. It appears that these proteins are distantly related to the PDDEXK superfamily and so these domains are likely to be nucleases. This family has a C-terminal cysteine cluster similar to that found in [pfam:PF01930].","domain_architectures":11,"interpro_id":"IPR024432","known_evidence_count":null,"matches":1633,"name":"PDDEXK-like domain of unknown function (DUF3799)","partial_evidence_count":null,"pfam_id":"PF12684","proteins":1632,"proteomes":1445,"short_name":"DUF3799","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12684","structures":2,"taxa":2970,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12684.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":747,"domain_architectures":11,"matches":1633,"proteins":1632,"proteomes":1445,"structures":2,"taxa":2970},"curation_status":"SEEDED","description":"This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 265 and 420 amino acids in length. It appears that these proteins are distantly related to the PDDEXK superfamily and so these domains are likely to be nucleases. This family has a C-terminal cysteine cluster similar to that found in [pfam:PF01930].","id":"Pfam:PF12684","interpro_id":"InterPro:IPR024432","name":"PDDEXK-like domain of unknown function (DUF3799)","pfam_id":"PF12684","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF3799","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12684"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12684.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"66d911a4a3b56b312f9f220d2a9c2534eb60a046043a0d6b467ae96f662488cb"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Escherichia coli (strain K12)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/double-stranded-dna-5-3-dna-exonuclease-activity-go0051908.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0051908","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/double-stranded-dna-5-3-dna-exonuclease-activity-go0051908.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/protein_family/ncbifam/exodeoxyribonuclease-viii-nf007259.yaml","qualification_status":"NOT_ASSESSED","record_id":"NCBIfam:NF007259","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/protein_family/ncbifam/exodeoxyribonuclease-viii-nf007259.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/putative-exodeoxyribonuclease-8-pddexk-like-domain-ipr024432.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR024432","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/putative-exodeoxyribonuclease-8-pddexk-like-domain-ipr024432.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf3799-pf12684.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12684","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf3799-pf12684.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/exonuc-viii-pf06630.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF06630","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/exonuc-viii-pf06630.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:P15032","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF06630","PF12684","PF30430"],"protein_name":"Exodeoxyribonuclease 8","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"27e1844a59b68231c8b529445db08b199f4cc0873f217d105d63f287fbee99c6","sequence_version":3,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSTKPLFLLRKAKKSSGEPDVVLWASNDFESTCATLDYLIVKSGKKLSSYFKAVATNFPVVNDLPAEGEIDFTWSERYQLSKDSMTWELKPGAAPDNAHYQGNTNVNGEDMTEIEENMLLPISGQELPIRWLAQHGSEKPVTHVSRDGLQALHIARAEELPAVTALAVSHKTSLLDPLEIRELHKLVRDTDKVFPNPGNSNLGLITAFFEAYLNADYTDRGLLTKEWMKGNRVSHITRTASGANAGGGNLTDRGEGFVHDLTSLARDVATGVLARSMDLDIYNLHPAHAKRIEEIIAENKPPFSVFRDKFITMPGGLDYSRAIVVASVKEAPIGIEVIPAHVTEYLNKVLTETDHANPDPEIVDIACGRSSAPMPQRVTEEGKQDDEEKPQPSGTTAVEQGEAETMEPDATEHHQDTQPLDAQSQVNSVDAKYQELRAELHEARKNIPSKNPVDDDKLLAASRGEFVDGISDPNDPKWVKGIQTRDCVYQNQPETEKTSPDMNQPEPVVQQEPEIACNACGQTGGDNCPDCGAVMGDATYQETFDEESQVEAKENDPEEMEGAEHPHNENAGSDPHRDCSDETGEVADPVIVEDIEPGIYYGISNENYHAGPGISKSQLDDIADTPALYLWRKNAPVDTTKTKTLDLGTAFHCRVLEPEEFSNRFIVAPEFNRRTNAGKEEEKAFLMECASTGKTVITAEEGRKIELMYQSVMALPLGQWLVESAGHAESSIYWEDPETGILCRCRPDKIIPEFHWIMDVKTTADIQRFKTAYYDYRYHVQDAFYSDGYEAQFGVQPTFVFLVASTTIECGRYPVEIFMMGEEAKLAGQQEYHRNLRTLSDCLNTDEWPAIKTLSLPRWAKEYAND","sequence_length":866,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"27e1844a59b68231c8b529445db08b199f4cc0873f217d105d63f287fbee99c6","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/P15032.json","taxon_id":"83333","uniprot_accession":"P15032","uniprot_release":"2026_03"}],"pfam_id":"PF12684","short_name":"DUF3799","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}