{"cross_mech":[],"family":{"alphafold_models":670,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents an alpha/beta domain found in the KIAA1549 protein from human ([swissprot:Q9HCM3]) which has been implicated in pilocytic astrocytomas [[cite:PUB00056166],[cite:PUB00056167],[cite:PUB00056168]]. It has been found to be fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34 [[cite:PUB00056166],[cite:PUB00056167]]. The BRAF protein is a well characterised oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion [[cite:PUB00056166],[cite:PUB00056167],[cite:PUB00056168]]. More recently, KIAA1549 has been described to play a role in photoreceptor function [[cite:PUB00101492]]. This protein contains three homologous domains of this type found in tandem.","domain_architectures":17,"interpro_id":"IPR024606","known_evidence_count":null,"matches":2276,"name":"UPF0606 protein KIAA1549 alpha/beta domain 2","partial_evidence_count":null,"pfam_id":"PF12877","proteins":2272,"proteomes":734,"short_name":"KIAA1549","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12877","structures":0,"taxa":2277,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF12877.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":670,"domain_architectures":17,"matches":2276,"proteins":2272,"proteomes":734,"structures":0,"taxa":2277},"curation_status":"SEEDED","description":"This entry represents an alpha/beta domain found in the KIAA1549 protein from human ([swissprot:Q9HCM3]) which has been implicated in pilocytic astrocytomas [[cite:PUB00056166],[cite:PUB00056167],[cite:PUB00056168]]. It has been found to be fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34 [[cite:PUB00056166],[cite:PUB00056167]]. The BRAF protein is a well characterised oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion [[cite:PUB00056166],[cite:PUB00056167],[cite:PUB00056168]]. More recently, KIAA1549 has been described to play a role in photoreceptor function [[cite:PUB00101492]]. This protein contains three homologous domains of this type found in tandem.","id":"Pfam:PF12877","interpro_id":"InterPro:IPR024606","name":"UPF0606 protein KIAA1549 alpha/beta domain 2","pfam_id":"PF12877","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"KIAA1549","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12877"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF12877.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"34c281f927bf809e96447c83d9fb4825a9e9c4fb2566c4645ee20a1bf8cb58e7"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus 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protein 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sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/upf0606-protein-kiaa1549-alpha-beta-domain-2-ipr024606.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR024606","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/upf0606-protein-kiaa1549-alpha-beta-domain-2-ipr024606.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/kiaa1549-pf12877.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12877","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/kiaa1549-pf12877.yaml"}],"pfam_ids":["PF12877","PF29951","PF29952"],"protein_name":"UPF0606 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sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/upf0606-protein-kiaa1549-alpha-beta-domain-2-ipr024606.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR024606","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/upf0606-protein-kiaa1549-alpha-beta-domain-2-ipr024606.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/kiaa1549-pf12877.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF12877","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/kiaa1549-pf12877.yaml"}],"pfam_ids":["PF12877","PF29951","PF29952"],"protein_name":"UPF0606 protein 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