{"cross_mech":[],"family":{"alphafold_models":273,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins is found in bacteria. Family members are approximately 40 amino acids in length. There is a conserved GKAW sequence motif. There is a single completely conserved residue G that may be functionally important. Family members include the Bacillus subtilis cell-division inhibitor, MciZ (mother cell inhibitor of FtsZ) which blocks the assembly of FtsZ. FtsZ (filamentation temperature-sensitive Z) is the bacterial homolog of tubulin. Crystal structure reveals that MciZ binds to the C-terminal polymerization interface of FtsZ, the equivalent of the minus end of tubulin, causing shortening of protofilaments and blocking the assembly of higher-order FtsZ structures. Hence, MciZ provides a capping-based regulatory mechanism for FtsZ [[cite:PUB00091017]].","domain_architectures":2,"interpro_id":"IPR025177","known_evidence_count":null,"matches":471,"name":"Mother cell inhibitor of FtsZ","partial_evidence_count":null,"pfam_id":"PF13072","proteins":471,"proteomes":469,"short_name":"MciZ","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13072","structures":2,"taxa":610,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF13072.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":273,"domain_architectures":2,"matches":471,"proteins":471,"proteomes":469,"structures":2,"taxa":610},"curation_status":"SEEDED","description":"This family of proteins is found in bacteria. Family members are approximately 40 amino acids in length. There is a conserved GKAW sequence motif. There is a single completely conserved residue G that may be functionally important. Family members include the Bacillus subtilis cell-division inhibitor, MciZ (mother cell inhibitor of FtsZ) which blocks the assembly of FtsZ. FtsZ (filamentation temperature-sensitive Z) is the bacterial homolog of tubulin. Crystal structure reveals that MciZ binds to the C-terminal polymerization interface of FtsZ, the equivalent of the minus end of tubulin, causing shortening of protofilaments and blocking the assembly of higher-order FtsZ structures. Hence, MciZ provides a capping-based regulatory mechanism for FtsZ [[cite:PUB00091017]].","id":"Pfam:PF13072","interpro_id":"InterPro:IPR025177","name":"Mother cell inhibitor of FtsZ","pfam_id":"PF13072","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"MciZ","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13072"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF13072.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"86aba15b659ba2d9ccf2708f143e24a669b44723c955a9aa2c3b49c41965c960"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/mciz-pf13072.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF13072","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/mciz-pf13072.yaml"}],"pfam_ids":["PF13072"],"protein_name":"Cell division inhibitor MciZ","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP","sequence_length":40,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8efeaf3dc50073c79f6d1b87f1fb4c37223fc5b7a88641209c3b6e424c2bc370","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/L8EBJ9.json","taxon_id":"224308","uniprot_accession":"L8EBJ9","uniprot_release":"2026_03"}],"pfam_id":"PF13072","short_name":"MciZ","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
