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ARC6 is evolutionarily related to the cyanobacterial cell division protein Ftn2/ZipN [[cite:PUB00096838]], having similar structures. This domain from ARC6 and PARC6 interacts with PDV2 and PDV1 respectively. PDV proteins recruit dynamin-like ARC5 ring to the chloroplast surface and mediates its constriction. ARC6/PARC6 are key to connect and coordinate Fst and ARC5 rings during fission [[cite:PUB00096837],[cite:PUB00096840]].","domain_architectures":42,"interpro_id":"IPR025344","known_evidence_count":null,"matches":1587,"name":"ARC6-like, IMS domain","partial_evidence_count":null,"pfam_id":"PF13355","proteins":1579,"proteomes":668,"short_name":"ARC6-like_IMS","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13355","structures":7,"taxa":1893,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF13355.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1214,"domain_architectures":42,"matches":1587,"proteins":1579,"proteomes":668,"structures":7,"taxa":1893},"curation_status":"SEEDED","description":"This domain corresponds to the C-terminal intermembrane space (IMS) region from protein accumulation and replication of chloroplasts 6 (ARC6) and its paralogue PARC6 [[cite:PUB00096838]]. ARC6 and PARC6 are components of the plastid division machinery which are essential for the chloroplast replication process [[cite:PUB00096838],[cite:PUB00096839]], which implies the assembly and constriction of the tubulin-like FtsZ ring on the stromal surface of the inner envelope membrane (IEM) and the dynamin-like ARC5 ring on the cytosolic surface of the outer envelope membrane (OEM). ARC6 is evolutionarily related to the cyanobacterial cell division protein Ftn2/ZipN [[cite:PUB00096838]], having similar structures. This domain from ARC6 and PARC6 interacts with PDV2 and PDV1 respectively. PDV proteins recruit dynamin-like ARC5 ring to the chloroplast surface and mediates its constriction. ARC6/PARC6 are key to connect and coordinate Fst and ARC5 rings during fission [[cite:PUB00096837],[cite:PUB00096840]].","id":"Pfam:PF13355","interpro_id":"InterPro:IPR025344","name":"ARC6-like, IMS 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