{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF13821","protein_label":"Uncharacterized protein YLR271W","reviewed":true,"short_name":"DUF4187","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml","source_record_id":"InterPro:IPR025239","source_record_label":"Domain of unknown function DUF4187","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"Q06152","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF13821","protein_label":"G patch domain-containing protein 11","reviewed":true,"short_name":"DUF4187","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml","source_record_id":"InterPro:IPR025239","source_record_label":"Domain of unknown function DUF4187","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q3UFS4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF13821","protein_label":"G patch domain-containing protein 11","reviewed":true,"short_name":"DUF4187","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml","source_record_id":"InterPro:IPR025239","source_record_label":"Domain of unknown function DUF4187","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N954","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF13821","protein_label":"","reviewed":null,"short_name":"DUF4187","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml","source_record_id":"InterPro:IPR025239","source_record_label":"Domain of unknown function DUF4187","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF13821","protein_label":"Uncharacterized protein YLR271W","reviewed":true,"short_name":"DUF4187","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4187-pf13821.yaml","source_record_id":"Pfam:PF13821","source_record_label":"Domain of unknown function (DUF4187)","source_section":"canonical_examples","taxon_id":"NCBITaxon:559292","taxon_label":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","uniprot_accession":"Q06152","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF13821","protein_label":"G patch domain-containing protein 11","reviewed":true,"short_name":"DUF4187","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4187-pf13821.yaml","source_record_id":"Pfam:PF13821","source_record_label":"Domain of unknown function (DUF4187)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q3UFS4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF13821","protein_label":"G patch domain-containing protein 11","reviewed":true,"short_name":"DUF4187","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4187-pf13821.yaml","source_record_id":"Pfam:PF13821","source_record_label":"Domain of unknown function (DUF4187)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N954","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF13821","protein_label":"","reviewed":null,"short_name":"DUF4187","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4187-pf13821.yaml","source_record_id":"Pfam:PF13821","source_record_label":"Domain of unknown function (DUF4187)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":3582,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family is found at the very C-terminus of proteins that carry a G-patch domain, [pfam:PF01585]. The domain is short and cysteine-rich.","domain_architectures":58,"interpro_id":"IPR025239","known_evidence_count":null,"matches":4205,"name":"Domain of unknown function (DUF4187)","partial_evidence_count":null,"pfam_id":"PF13821","proteins":4203,"proteomes":2874,"short_name":"DUF4187","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13821","structures":0,"taxa":7658,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF13821.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3582,"domain_architectures":58,"matches":4205,"proteins":4203,"proteomes":2874,"structures":0,"taxa":7658},"curation_status":"SEEDED","description":"This family is found at the very C-terminus of proteins that carry a G-patch domain, [pfam:PF01585]. The domain is short and cysteine-rich.","id":"Pfam:PF13821","interpro_id":"InterPro:IPR025239","name":"Domain of unknown function (DUF4187)","pfam_id":"PF13821","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4187","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13821"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF13821.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c8628c9bcf6580cb1b5fab65066266373a8364e0af6fd9bed725f4bf55b61fa1"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR025239","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4187-pf13821.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF13821","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4187-pf13821.yaml"}],"pfam_ids":["PF01585","PF13821"],"protein_name":"Uncharacterized protein YLR271W","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEESKTKRKEDRIDLKNTPPQKKSKRDSTNDETARTSLRSIMPRGYKMMENMGYKEGETLGSNESALKEPIKVEINTKRRGIRAEKPDPSTMNDMQMSEQRFIKRESEMKNNKRLKKIWYRIQKVAFEMMGDSDLYNPGEDPRDFNVLWRSYVMQLNEEVAKNDLNNHSNNDNEDKNNMIPMVNESLEASPAIKGEKFGRPSTLIDCDTSIIGSRITKDTELAELEELSIEKRITKLNIFLRSEKYYCFFCGIKYKDEGDLYEHCPGVNEDDHK","sequence_length":274,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"19be598239a6bdf0e283bb55fb8a057f7d39e3f6fc05a4d2f78fae9d83b58900","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q06152.json","taxon_id":"559292","uniprot_accession":"Q06152","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR025239","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4187-pf13821.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF13821","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4187-pf13821.yaml"}],"pfam_ids":["PF01585","PF13821"],"protein_name":"G patch domain-containing protein 11","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTEEEDYMSDSFINVQEDVRPGVPMLRQIREARRKEEKQQQANLRNRQKSVKEEERERRDIGLKNALGCENKGFALLQKMGYKSGQALGKSGDGIVEPIPLNVKTGKSGIGHESSLKRKAEERLENYRRKIHMKNQNEAKAAEEFRMRLKSKQDEMRLEGDLRRSQRACQQLDAQKNIQVPREAWYWLRPEEETEEEEEEEEKEEQDEDECPSEDLSVLEKLQILTGYLREEHLYCIWCGTAYEDKEDLSSNCPGPTSADHD","sequence_length":262,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"231631a2f5343beb8d51ef16cdfd82b5a9941d4530cd1f83bc0213c551599e7c","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q3UFS4.json","taxon_id":"10090","uniprot_accession":"Q3UFS4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR025239","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4187-ipr025239.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4187-pf13821.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF13821","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4187-pf13821.yaml"}],"pfam_ids":["PF01585","PF13821"],"protein_name":"G patch domain-containing protein 11","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRSARSTALNRGEQRAVRYYSHMKLNMAEEEDYMSDSFINVQEDIRPGLPMLRQIREARRKEEKQQEANLKNRQKSLKEEEQERRDIGLKNALGCENKGFALLQKMGYKSGQALGKSGGGIVEPIPLNIKTGKSGIGHEASLKRKAEEKLESYRKKIHMKNQAEEKAAEQFRMRLKNKQDEMKLEGDLRRSQRACQQLDVQKNIQVPREAWYWLRLEEETEEDEEEKEQDEDEYKSEDLSVLEKLQILTSYLREEHLYCIWCGTAYEDKEDLSSNCPGPTSADHD","sequence_length":285,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"60935118174a6b898acfbfff3c5d32e9a0bb91293e99ceb11fa2aa205f3ba2f4","sequence_version":4,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N954.json","taxon_id":"9606","uniprot_accession":"Q8N954","uniprot_release":"2026_03"}],"pfam_id":"PF13821","short_name":"DUF4187","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}