{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF13827","protein_label":"","reviewed":null,"short_name":"DUF4189","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4189-ipr025240.yaml","source_record_id":"InterPro:IPR025240","source_record_label":"Domain of unknown function DUF4189","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF13827","protein_label":"Protein Mb1300c","reviewed":true,"short_name":"DUF4189","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4189-pf13827.yaml","source_record_id":"Pfam:PF13827","source_record_label":"Domain of unknown function (DUF4189)","source_section":"canonical_examples","taxon_id":"NCBITaxon:233413","taxon_label":"Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)","uniprot_accession":"P0A5E2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF13827","protein_label":"Protein MT1307","reviewed":true,"short_name":"DUF4189","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4189-pf13827.yaml","source_record_id":"Pfam:PF13827","source_record_label":"Domain of unknown function (DUF4189)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83331","taxon_label":"Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)","uniprot_accession":"P9WM44","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF13827","protein_label":"Protein Rv1269c","reviewed":true,"short_name":"DUF4189","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4189-pf13827.yaml","source_record_id":"Pfam:PF13827","source_record_label":"Domain of unknown function (DUF4189)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83332","taxon_label":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","uniprot_accession":"P9WM45","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF13827","protein_label":"","reviewed":null,"short_name":"DUF4189","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4189-pf13827.yaml","source_record_id":"Pfam:PF13827","source_record_label":"Domain of unknown function (DUF4189)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1227,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","description_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain of unknown function contains six well-conserved cysteine residues.","domain_architectures":22,"interpro_id":"IPR025240","known_evidence_count":null,"matches":2152,"name":"Domain of unknown function (DUF4189)","partial_evidence_count":null,"pfam_id":"PF13827","proteins":2037,"proteomes":1117,"short_name":"DUF4189","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13827","structures":1,"taxa":1768,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF13827.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1227,"domain_architectures":22,"matches":2152,"proteins":2037,"proteomes":1117,"structures":1,"taxa":1768},"curation_status":"SEEDED","description":"This domain of unknown function contains six well-conserved cysteine residues.","id":"Pfam:PF13827","interpro_id":"InterPro:IPR025240","name":"Domain of unknown function (DUF4189)","pfam_id":"PF13827","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4189","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13827"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF13827.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c79e857d281f78f26cc400557a47fac1c78fee163d25952869137442f27fa5c6"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4189-pf13827.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF13827","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4189-pf13827.yaml"}],"pfam_ids":["PF13827"],"protein_name":"Protein Mb1300c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTTMITLRRRFAVAVAGVATAAATTVTLAPAPANAADVYGAIAYSGNGSWGRSWDYPTRAAAEATAVKSCGYSDCKVLTSFTACGAVAANDRAYQGGVGPTLAAAMKDALTKLGGGYIDTWACN","sequence_length":124,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5b484dcc2e808fdba36100f433a67203902d13ca49db55fbd94cceaed2ffc1cc","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0A5E2.json","taxon_id":"233413","uniprot_accession":"P0A5E2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4189-pf13827.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF13827","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4189-pf13827.yaml"}],"pfam_ids":["PF13827"],"protein_name":"Protein MT1307","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTTMITLRRRFAVAVAGVATAAATTVTLAPAPANAADVYGAIAYSGNGSWGRSWDYPTRAAAEATAVKSCGYSDCKVLTSFTACGAVAANDRAYQGGVGPTLAAAMKDALTKLGGGYIDTWACN","sequence_length":124,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5b484dcc2e808fdba36100f433a67203902d13ca49db55fbd94cceaed2ffc1cc","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WM44.json","taxon_id":"83331","uniprot_accession":"P9WM44","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4189-pf13827.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF13827","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4189-pf13827.yaml"}],"pfam_ids":["PF13827"],"protein_name":"Protein Rv1269c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTTMITLRRRFAVAVAGVATAAATTVTLAPAPANAADVYGAIAYSGNGSWGRSWDYPTRAAAEATAVKSCGYSDCKVLTSFTACGAVAANDRAYQGGVGPTLAAAMKDALTKLGGGYIDTWACN","sequence_length":124,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"5b484dcc2e808fdba36100f433a67203902d13ca49db55fbd94cceaed2ffc1cc","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WM45.json","taxon_id":"83332","uniprot_accession":"P9WM45","uniprot_release":"2026_03"}],"pfam_id":"PF13827","short_name":"DUF4189","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}