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On the other hand, Pacer positively regulates autophagy, promoting autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns3P) in late steps of autophagy; it antagonises RUBCN [[cite:PUB00101000]]. This domain contains nine conserved cysteines and one conserved histidine, which have been predicted to bind divalent zinc cations being required for Rubicon and PLEKHM1 to interact with Rab7.","domain_architectures":123,"interpro_id":"IPR025258","known_evidence_count":null,"matches":8152,"name":"Rubicon Homology Domain","partial_evidence_count":null,"pfam_id":"PF13901","proteins":8015,"proteomes":1750,"short_name":"RH_dom","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13901","structures":1,"taxa":5484,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF13901.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":6861,"domain_architectures":123,"matches":8152,"proteins":8015,"proteomes":1750,"structures":1,"taxa":5484},"curation_status":"SEEDED","description":"This is the Rubicon homology domain (RH) characterised at the C-terminal of Rubicon, PLEKHM1 and Pacer, proteins that modulate late steps in autophagy [[cite:PUB00100995],[cite:PUB00100997]]. 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