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EMARD may play a role in neuronal migration during embryonic development [[cite:PUB00089893]].","domain_architectures":24,"interpro_id":"IPR025209","known_evidence_count":null,"matches":1523,"name":"EMARD, N-terminal domain","partial_evidence_count":null,"pfam_id":"PF13910","proteins":1409,"proteomes":793,"short_name":"EMARD_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13910","structures":0,"taxa":2656,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF13910.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1213,"domain_architectures":24,"matches":1523,"proteins":1409,"proteomes":793,"structures":0,"taxa":2656},"curation_status":"SEEDED","description":"This entry represents the KEN domain found at the N-terminal of Endoplasmic reticulum membrane-associated RNA degradation protein (EMARD, also known as C6orf70 in human), which belongs to the HEPN superfamily. It carries the characteristic, highly conserved RxxxxHG sequence motif [[cite:PUB00091124]]. This domain may be a RNase that is involved in the degradation of rRNAs, mRNAs associated with the endoplasmic reticulum membrane. EMARD may play a role in neuronal migration during embryonic development [[cite:PUB00089893]].","id":"Pfam:PF13910","interpro_id":"InterPro:IPR025209","name":"EMARD, N-terminal 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