{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14216","protein_label":"","reviewed":null,"short_name":"DUF4326","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4326-ipr025475.yaml","source_record_id":"InterPro:IPR025475","source_record_label":"Domain of unknown function DUF4326","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14216","protein_label":"Uncharacterized 12.4 kDa protein in nrdA-td intergenic region","reviewed":true,"short_name":"DUF4326","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4326-pf14216.yaml","source_record_id":"Pfam:PF14216","source_record_label":"Domain of unknown function (DUF4326)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10665","taxon_label":"Enterobacteria phage T4","uniprot_accession":"P32279","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14216","protein_label":"Uncharacterized protein R718","reviewed":true,"short_name":"DUF4326","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4326-pf14216.yaml","source_record_id":"Pfam:PF14216","source_record_label":"Domain of unknown function (DUF4326)","source_section":"canonical_examples","taxon_id":"NCBITaxon:212035","taxon_label":"Acanthamoeba polyphaga mimivirus","uniprot_accession":"Q5UNW9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14216","protein_label":"","reviewed":null,"short_name":"DUF4326","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4326-pf14216.yaml","source_record_id":"Pfam:PF14216","source_record_label":"Domain of unknown function (DUF4326)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":752,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 100 and 162 amino acids in length. There are two completely conserved residues (P and C) that may be functionally important.","domain_architectures":42,"interpro_id":"IPR025475","known_evidence_count":null,"matches":1711,"name":"Domain of unknown function (DUF4326)","partial_evidence_count":null,"pfam_id":"PF14216","proteins":1711,"proteomes":1466,"short_name":"DUF4326","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14216","structures":0,"taxa":3226,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14216.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":752,"domain_architectures":42,"matches":1711,"proteins":1711,"proteomes":1466,"structures":0,"taxa":3226},"curation_status":"SEEDED","description":"This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 100 and 162 amino acids in length. There are two completely conserved residues (P and C) that may be functionally important.","id":"Pfam:PF14216","interpro_id":"InterPro:IPR025475","name":"Domain of unknown function (DUF4326)","pfam_id":"PF14216","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4326","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14216"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14216.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"fc03b91183944d922892bbe5dfe48c9f4b5e38a1ea6fb8d3431c4be89e4f1053"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Enterobacteria phage T4","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4326-pf14216.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14216","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4326-pf14216.yaml"}],"pfam_ids":["PF14216"],"protein_name":"Uncharacterized 12.4 kDa protein in nrdA-td intergenic region","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTNYSSVGRLCRVVNKYKSDFDVNIHRGTFWGNYVGKDAGSREAAIELFKKDFIRRIKSGEITKAHLEPLRGMRLGCTCKPKPCHGDIIAHIVNRLFKDDFQVEDLCN","sequence_length":108,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e025ba558fb6d6acd56a3da7ad6b7c1f0491cdde6b885af6892f4088df9119ac","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P32279.json","taxon_id":"10665","uniprot_accession":"P32279","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Acanthamoeba polyphaga mimivirus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4326-pf14216.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14216","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4326-pf14216.yaml"}],"pfam_ids":["PF14216"],"protein_name":"Uncharacterized protein R718","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTAPILVRIKRNKNDIVQNCDVYIGRQCNMGGWNLPDSKWKNPFTIKQYGSAEIVCEKYFKYIVSSDLFHDIPELKSKTIGCWCDFPVNKIITGFYCHGCVLIQLYKLIEKYDFDTHKIQSILKKAFCCD","sequence_length":130,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b4344147a1109c8e805b9f4e0bc9513586314f8172ef34e119ff352ae59f6245","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5UNW9.json","taxon_id":"212035","uniprot_accession":"Q5UNW9","uniprot_release":"2026_03"}],"pfam_id":"PF14216","short_name":"DUF4326","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}