{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14230","protein_label":"","reviewed":null,"short_name":"DUF4333","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4333-ipr025637.yaml","source_record_id":"InterPro:IPR025637","source_record_label":"Domain of unknown function DUF4333","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14230","protein_label":"Uncharacterized protein Mb2118c","reviewed":true,"short_name":"DUF4333","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4333-pf14230.yaml","source_record_id":"Pfam:PF14230","source_record_label":"Domain of unknown function (DUF4333)","source_section":"canonical_examples","taxon_id":"NCBITaxon:233413","taxon_label":"Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)","uniprot_accession":"P64940","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14230","protein_label":"Uncharacterized protein MT2152","reviewed":true,"short_name":"DUF4333","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4333-pf14230.yaml","source_record_id":"Pfam:PF14230","source_record_label":"Domain of unknown function (DUF4333)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83331","taxon_label":"Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)","uniprot_accession":"P9WLJ4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14230","protein_label":"Uncharacterized protein Rv2091c","reviewed":true,"short_name":"DUF4333","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4333-pf14230.yaml","source_record_id":"Pfam:PF14230","source_record_label":"Domain of unknown function (DUF4333)","source_section":"canonical_examples","taxon_id":"NCBITaxon:83332","taxon_label":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","uniprot_accession":"P9WLJ5","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14230","protein_label":"","reviewed":null,"short_name":"DUF4333","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4333-pf14230.yaml","source_record_id":"Pfam:PF14230","source_record_label":"Domain of unknown function (DUF4333)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1490,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 140 and 255 amino acids in length. There are two completely conserved C residues that may be functionally important.","domain_architectures":9,"interpro_id":"IPR025637","known_evidence_count":null,"matches":2649,"name":"Domain of unknown function (DUF4333)","partial_evidence_count":null,"pfam_id":"PF14230","proteins":2361,"proteomes":1354,"short_name":"DUF4333","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14230","structures":0,"taxa":1774,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14230.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1490,"domain_architectures":9,"matches":2649,"proteins":2361,"proteomes":1354,"structures":0,"taxa":1774},"curation_status":"SEEDED","description":"This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 140 and 255 amino acids in length. There are two completely conserved C residues that may be functionally important.","id":"Pfam:PF14230","interpro_id":"InterPro:IPR025637","name":"Domain of unknown function (DUF4333)","pfam_id":"PF14230","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4333","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14230"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14230.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"2240ca10380cb7d0d356ee7d8fff8276c127de0747ca0247dffbca983baf0b98"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4333-pf14230.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14230","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4333-pf14230.yaml"}],"pfam_ids":["PF14230"],"protein_name":"Uncharacterized protein Mb2118c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSGPQGSDPRQPWQPPGQGADHSSDPTVAAGYPWQQQPTQEATWQAPAYTPQYQQPADPAYPQQYPQPTPGYAQPEQFGAQPTQLGVPGQYGQYQQPGQYGQPGQYGQPGQYAPPGQYPGQYGPYGQSGQGSKRSVAVIGGVIAVMAVLFIGAVLILGFWAPGFFVTTKLDVIKAQAGVQQVLTDETTGYGAKNVKDVKCNNGSDPTVKKGATFECTVSIDGTSKRVTVTFQDNKGTYEVGRPQ","sequence_length":244,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c27eea62cbb8496f7284a63c7ab03fbc40593e8a2278859c8e03e3b8e7399e4c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P64940.json","taxon_id":"233413","uniprot_accession":"P64940","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4333-pf14230.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14230","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4333-pf14230.yaml"}],"pfam_ids":["PF14230"],"protein_name":"Uncharacterized protein MT2152","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSGPQGSDPRQPWQPPGQGADHSSDPTVAAGYPWQQQPTQEATWQAPAYTPQYQQPADPAYPQQYPQPTPGYAQPEQFGAQPTQLGVPGQYGQYQQPGQYGQPGQYGQPGQYAPPGQYPGQYGPYGQSGQGSKRSVAVIGGVIAVMAVLFIGAVLILGFWAPGFFVTTKLDVIKAQAGVQQVLTDETTGYGAKNVKDVKCNNGSDPTVKKGATFECTVSIDGTSKRVTVTFQDNKGTYEVGRPQ","sequence_length":244,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c27eea62cbb8496f7284a63c7ab03fbc40593e8a2278859c8e03e3b8e7399e4c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WLJ4.json","taxon_id":"83331","uniprot_accession":"P9WLJ4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4333-pf14230.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14230","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4333-pf14230.yaml"}],"pfam_ids":["PF14230"],"protein_name":"Uncharacterized protein Rv2091c","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSGPQGSDPRQPWQPPGQGADHSSDPTVAAGYPWQQQPTQEATWQAPAYTPQYQQPADPAYPQQYPQPTPGYAQPEQFGAQPTQLGVPGQYGQYQQPGQYGQPGQYGQPGQYAPPGQYPGQYGPYGQSGQGSKRSVAVIGGVIAVMAVLFIGAVLILGFWAPGFFVTTKLDVIKAQAGVQQVLTDETTGYGAKNVKDVKCNNGSDPTVKKGATFECTVSIDGTSKRVTVTFQDNKGTYEVGRPQ","sequence_length":244,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c27eea62cbb8496f7284a63c7ab03fbc40593e8a2278859c8e03e3b8e7399e4c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P9WLJ5.json","taxon_id":"83332","uniprot_accession":"P9WLJ5","uniprot_release":"2026_03"}],"pfam_id":"PF14230","short_name":"DUF4333","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}