{"cross_mech":[],"family":{"alphafold_models":1483,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the C-terminal domain of mitochondrial D-glutamate cyclase, which converts D-glutamate to 5-oxo-D-proline [[cite:PUB00086027]]. This is a conserved domain also found in uncharacterised proteins from bacteria and archaea. Structural studies of the hypothetical protein TON_0340 from Thermococcus onnurineus revealed an active-site cavity harbouring a metal-binding site containing six invariant aspartate and glutamate residues that adopts an alpha/beta-structure [[cite:PUB00151593]]. Biochemical and mutational analysis show that TON_0340 is a Mn+2-dependent phosphatase [[cite:PUB00151593]].","domain_architectures":16,"interpro_id":"IPR025504","known_evidence_count":null,"matches":1931,"name":"D-glutamate cyclase-like, C-terminal","partial_evidence_count":null,"pfam_id":"PF14336","proteins":1872,"proteomes":1349,"short_name":"GLUCM-like_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14336","structures":6,"taxa":3617,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14336.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1483,"domain_architectures":16,"matches":1931,"proteins":1872,"proteomes":1349,"structures":6,"taxa":3617},"curation_status":"SEEDED","description":"This entry represents the C-terminal domain of mitochondrial D-glutamate cyclase, which converts D-glutamate to 5-oxo-D-proline [[cite:PUB00086027]]. This is a conserved domain also found in uncharacterised proteins from bacteria and archaea. Structural studies of the hypothetical protein TON_0340 from Thermococcus onnurineus revealed an active-site cavity harbouring a metal-binding site containing six invariant aspartate and glutamate residues that adopts an alpha/beta-structure [[cite:PUB00151593]]. Biochemical and mutational analysis show that TON_0340 is a Mn+2-dependent phosphatase [[cite:PUB00151593]].","id":"Pfam:PF14336","interpro_id":"InterPro:IPR025504","name":"D-glutamate cyclase-like, C-terminal","pfam_id":"PF14336","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"GLUCM-like_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14336"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14336.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"bd60044e304e95b9d3f8f8c1c713f4881fbe1a21d11a5df46aca01431a187275"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/d-glutamate-cyclase-activity-go0047820.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0047820","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/d-glutamate-cyclase-activity-go0047820.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/d-glutamate-cyclase-like-c-terminal-ipr025504.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR025504","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/d-glutamate-cyclase-like-c-terminal-ipr025504.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/d-glutamate-cyclase-like-domain-ipr009906.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009906","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/d-glutamate-cyclase-like-domain-ipr009906.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/glucm-like-c-pf14336.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14336","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/glucm-like-c-pf14336.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/d-glu-cyclase-pf07286.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF07286","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/d-glu-cyclase-pf07286.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/putative-hydro-lyase-ipr038021.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038021","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/putative-hydro-lyase-ipr038021.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/pstpo5379-like-3-40-1640-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.1640.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/pstpo5379-like-3-40-1640-10.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/pstpo5379-like-domain-3-30-2040-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.2040.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/pstpo5379-like-domain-3-30-2040-10.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ton-0340-3-90-1640-20.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.90.1640.20","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ton-0340-3-90-1640-20.yaml"}],"pfam_ids":["PF07286","PF14336"],"protein_name":"D-glutamate cyclase, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPFTLHLRSRLPSAIRSLILQKKPNIRNTSSMAGELRPASLVVLPRSLAPAFERFCQVNTGPLPLLGQSEPEKWMLPPQGAISETRMGHPQFWKYEFGACTGSLASLEQYSEQLKDMVAFFLGCSFSLEEALEKAGLPRRDPAGHSQTTVPCVTHAGFCCPLVVTMRPIPKDKLEGLVRACCSLGGEQGQPVHMGDPELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSSCETPLAFASIPGCTVMTDLKDAKAPPGCLTPERIPEVHHISQDPLHYSIASVSASQKIRELESMIGIDPGNRGIGHLLCKDELLKASLSLSHARSVLITTGFPTHFNHEPPEETDGPPGAVALVAFLQALEKEVAIIVDQRAWNLHQKIVEDAVEQGVLKTQIPILTYQGGSVEAAQAFLCKNGDPQTPRFDHLVAIERAGRAADGNYYNARKMNIKHLVDPIDDLFLAAKKIPGISSTGVGDGGNELGMGKVKEAVRRHIRHGDVIACDVEADFAVIAGVSNWGGYALACALYILYSCAVHSQYLRKAVGPSRAPGDQAWTQALPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHNTHAEMIQKLVDVTTAQV","sequence_length":616,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3bf5dd1aafaee3541e8fe506a5e22b92c313704cfb2079a4f4685dfa826fac33","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q7Z3D6.json","taxon_id":"9606","uniprot_accession":"Q7Z3D6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/d-glutamate-cyclase-activity-go0047820.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0047820","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/d-glutamate-cyclase-activity-go0047820.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/d-glutamate-cyclase-like-c-terminal-ipr025504.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR025504","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/d-glutamate-cyclase-like-c-terminal-ipr025504.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/d-glutamate-cyclase-like-domain-ipr009906.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR009906","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/d-glutamate-cyclase-like-domain-ipr009906.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/glucm-like-c-pf14336.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14336","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/glucm-like-c-pf14336.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/d-glu-cyclase-pf07286.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF07286","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/d-glu-cyclase-pf07286.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/putative-hydro-lyase-ipr038021.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR038021","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/putative-hydro-lyase-ipr038021.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/pstpo5379-like-3-40-1640-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.40.1640.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/pstpo5379-like-3-40-1640-10.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/pstpo5379-like-domain-3-30-2040-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.2040.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/pstpo5379-like-domain-3-30-2040-10.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/ton-0340-3-90-1640-20.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.90.1640.20","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/ton-0340-3-90-1640-20.yaml"}],"pfam_ids":["PF07286","PF14336"],"protein_name":"D-glutamate cyclase, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTISFLLRSCLRSAVRSLPKAALIRNTSSMTEGLQPASVVVLPRSLAPAFESFCQGNRGPLPLLGQSEAVKTLPQLSAVSDIRTICPQLQKYKFGTCTGILTSLEEHSEQLKEMVTFIIDCSFSIEEALEQAGIPRRDLTGPSHAGAYKTTVPCATIAGFCCPLVVTMRPIPKDKLERLLQATHAIRGQQGQPIHIGDPGLLGIEALSKPDYGSYVECRPEDVPVFWPSPLTSLEAVISCKAPLAFASPPGCMVMVPKDTASSASCLTPEMVPEVHAISKDPLHYSIVSAPAAQKVRELESTIAVDPGNRGIGHLLLKDELLQAALSLSHARSVLVTTGFPTHFNHEPPEETDGPPGAIALAAFLQALGKETAMVVDQRALNLHMRIVEDAIRQGVLKTPIPILTYQGRSMEDARAFLCKDGDPKSPRFDHLVAIERAGRAADGNYYNARKMNIKHLVDPIDDIFLAAQKIPGISSTGVGDGGNELGMGKVKAAVKKHIRNGDVIACDVEADFAVIAGVSNWGGYALACALYILNSCQVHERYLRRATGPSRRAGEQSWIQALPSVAKEEKMLGILVENQVRSGVSGIVGMEVDGLPFHDVHAEMIRKLVGATTVHM","sequence_length":617,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7db65f8ea5feea7443a10d9f2cde19157d450539e7e112d4f2772927fbb72c7c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8BH86.json","taxon_id":"10090","uniprot_accession":"Q8BH86","uniprot_release":"2026_03"}],"pfam_id":"PF14336","short_name":"GLUCM-like_C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
