{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14494","protein_label":"","reviewed":null,"short_name":"DUF4436","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4436-ipr027948.yaml","source_record_id":"InterPro:IPR027948","source_record_label":"Domain of unknown function DUF4436","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14494","protein_label":"","reviewed":null,"short_name":"DUF4436","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4436-pf14494.yaml","source_record_id":"Pfam:PF14494","source_record_label":"Domain of unknown function (DUF4436)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":678,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":true,"records_by_mech":{},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a domain found in a family of membrane and transmembrane proteins from mycobacterial and related species. This domain has similarity to the ligand-binding domains of neurotransmitter ligand-gated ion channels and sensory receptors and it is likely to have similar function.","domain_architectures":11,"interpro_id":"IPR027948","known_evidence_count":null,"matches":936,"name":"Domain of unknown function (DUF4436)","partial_evidence_count":null,"pfam_id":"PF14494","proteins":936,"proteomes":500,"short_name":"DUF4436","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14494","structures":0,"taxa":869,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14494.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":678,"domain_architectures":11,"matches":936,"proteins":936,"proteomes":500,"structures":0,"taxa":869},"curation_status":"SEEDED","description":"This entry represents a domain found in a family of membrane and transmembrane proteins from mycobacterial and related species. This domain has similarity to the ligand-binding domains of neurotransmitter ligand-gated ion channels and sensory receptors and it is likely to have similar function.","id":"Pfam:PF14494","interpro_id":"InterPro:IPR027948","name":"Domain of unknown function (DUF4436)","pfam_id":"PF14494","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4436","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14494"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14494.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"82d95595b02ad90b4d26354ff94431dd309f421d33dc3214f1c8176c594f02eb"}},"protein_examples":{"candidate_count":0,"discovery_scanned":true,"example_count":0,"examples":[],"pfam_id":"PF14494","short_name":"DUF4436","status":"NO_SIBLING_CANDIDATE","unresolved":[]}}