{"cross_mech":[],"family":{"alphafold_models":929,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Ykl077w/Psg1 (Pma1 Stabilization in the Golgi) physically interacts with Exp1 (for ER eXport of Pma1). Psg1 can be found in the Golgi and coat protein I (COPI) vesicles but does not directly bind Pma1. Loss of Psg1 causes enhanced degradation of Pma1 in the vacuole. Psg1 is 392aa protein with a predicted signal sequence at its N-terminus and a single TMD near the C-terminus. The short cytosolic region bears 2 putative retrieval motifs KRR and KKxxKxx. It was previously shown to be cleaved by the Ca+ dependent serine protease, Kex2 [[cite:PUB00093685]].","domain_architectures":6,"interpro_id":"IPR028000","known_evidence_count":null,"matches":1122,"name":"Ykl077w/Psg1 (Pma1 Stabilization in Golgi)","partial_evidence_count":null,"pfam_id":"PF14610","proteins":1115,"proteomes":805,"short_name":"Psg1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14610","structures":0,"taxa":1646,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14610.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":929,"domain_architectures":6,"matches":1122,"proteins":1115,"proteomes":805,"structures":0,"taxa":1646},"curation_status":"SEEDED","description":"Ykl077w/Psg1 (Pma1 Stabilization in the Golgi) physically interacts with Exp1 (for ER eXport of Pma1). Psg1 can be found in the Golgi and coat protein I (COPI) vesicles but does not directly bind Pma1. Loss of Psg1 causes enhanced degradation of Pma1 in the vacuole. Psg1 is 392aa protein with a predicted signal sequence at its N-terminus and a single TMD near the C-terminus. The short cytosolic region bears 2 putative retrieval motifs KRR and KKxxKxx. It was previously shown to be cleaved by the Ca+ dependent serine protease, Kex2 [[cite:PUB00093685]].","id":"Pfam:PF14610","interpro_id":"InterPro:IPR028000","name":"Ykl077w/Psg1 (Pma1 Stabilization in Golgi)","pfam_id":"PF14610","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Psg1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14610"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14610.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"18e6e5139aa65fff3524a558fefa7ec822ba84428b496fe7f006e9340ebde3e7"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/psg1-pf14610.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14610","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/psg1-pf14610.yaml"}],"pfam_ids":["PF14610"],"protein_name":"PMA1 stabilization in the Golgi protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRFHDSILIFFSLASLYQHVHGARQVVRPKEKMTTSEEVKPWLRTVYGSQKELVTPTVIAGVTFSEKPEETPNPLKPWVSLEHDGRPKTIKPEINKGRTKKGRPDYSTYFKTVSSHTYSYEELKAHNMGPNEVFVEEEYIDEDDTYVSLNPIVRCTPNLYFNKGLAKDIRSEPFCTPYENSRWKVDKTYFVTWYTRFFTDENSGKVADKVRVHLSYVKENPVEKGNYKRDIPATFFSSEWIDNDNGLMPVEVRDEWLQDQFDRRIVVSVQPIYISDEDFDPLQYGILLYITKGSKVFKPTKEQLALDDAGITNDQWYYVALSIPTVVVVFFVFMYFFLYVNGKNRDFTDVTRKALNKKRRVLGKFSEMKKFKNMKNHKYTELPSYKKTSKQN","sequence_length":392,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9f11d16de0156c56e0422ae9fa91aea7b62a7658342166b769de4a6433cd7f44","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P36081.json","taxon_id":"559292","uniprot_accession":"P36081","uniprot_release":"2026_03"}],"pfam_id":"PF14610","short_name":"Psg1","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
