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The member [swissprot:Q7SB48], named HAM-13, is thought to associate with MAPKs and to be required for proper cell communication but it is also possible to be involved in other processes such as cell signalling or trafficking [[cite:PUB00110895]].","domain_architectures":29,"interpro_id":"IPR027842","known_evidence_count":null,"matches":1931,"name":"HAM1-like, C-terminal domain","partial_evidence_count":null,"pfam_id":"PF14613","proteins":1927,"proteomes":1257,"short_name":"HAM1_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14613","structures":0,"taxa":2678,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14613.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1593,"domain_architectures":29,"matches":1931,"proteins":1927,"proteomes":1257,"structures":0,"taxa":2678},"curation_status":"SEEDED","description":"This is a domain found at the C-terminal end of the putative cell signalling protein HAM1 from Cryptococcus neoformans and similar fungal sequences. HAM1 may act as a negative regulator of mating during vegetative growth [[cite:PUB00110896]]. Proteins with this domain often also contain an N-terminal domain [pfam:PF19343]. The member [swissprot:Q7SB48], named HAM-13, is thought to associate with MAPKs and to be required for proper cell communication but it is also possible to be involved in other processes such as cell signalling or trafficking [[cite:PUB00110895]].","id":"Pfam:PF14613","interpro_id":"InterPro:IPR027842","name":"HAM1-like, C-terminal 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cell signaling protein 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