{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4460-ipr028031.yaml","source_record_id":"InterPro:IPR028031","source_record_label":"Domain of unknown function DUF4460","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q66JZ4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4460-ipr028031.yaml","source_record_id":"InterPro:IPR028031","source_record_label":"Domain of unknown function DUF4460","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N3R3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14687","protein_label":"","reviewed":null,"short_name":"DUF4460","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4460-ipr028031.yaml","source_record_id":"InterPro:IPR028031","source_record_label":"Domain of unknown function DUF4460","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4461-ipr027989.yaml","source_record_id":"InterPro:IPR027989","source_record_label":"Domain of unknown function DUF4461","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q66JZ4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4461-ipr027989.yaml","source_record_id":"InterPro:IPR027989","source_record_label":"Domain of unknown function DUF4461","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N3R3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4460-pf14687.yaml","source_record_id":"Pfam:PF14687","source_record_label":"Domain of unknown function (DUF4460)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10116","taxon_label":"Rattus norvegicus","uniprot_accession":"P0DKR2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4460-pf14687.yaml","source_record_id":"Pfam:PF14687","source_record_label":"Domain of unknown function (DUF4460)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q66JZ4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4460-pf14687.yaml","source_record_id":"Pfam:PF14687","source_record_label":"Domain of unknown function (DUF4460)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N3R3","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14687","protein_label":"","reviewed":null,"short_name":"DUF4460","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4460-pf14687.yaml","source_record_id":"Pfam:PF14687","source_record_label":"Domain of unknown function (DUF4460)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4461-pf14688.yaml","source_record_id":"Pfam:PF14688","source_record_label":"Domain of unknown function (DUF4461)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10116","taxon_label":"Rattus norvegicus","uniprot_accession":"P0DKR2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4461-pf14688.yaml","source_record_id":"Pfam:PF14688","source_record_label":"Domain of unknown function (DUF4461)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q66JZ4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14687","protein_label":"T-cell activation inhibitor, mitochondrial","reviewed":true,"short_name":"DUF4460","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4461-pf14688.yaml","source_record_id":"Pfam:PF14688","source_record_label":"Domain of unknown function (DUF4461)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N3R3","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1695,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":4},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain family is found in eukaryotes, and is typically between 103 and 119 amino acids in length. There is a conserved HPD sequence motif. There are two completely conserved residues (N and F) that may be functionally important.","domain_architectures":34,"interpro_id":"IPR028031","known_evidence_count":null,"matches":1895,"name":"Domain of unknown function (DUF4460)","partial_evidence_count":null,"pfam_id":"PF14687","proteins":1894,"proteomes":1336,"short_name":"DUF4460","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14687","structures":5,"taxa":4279,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14687.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1695,"domain_architectures":34,"matches":1895,"proteins":1894,"proteomes":1336,"structures":5,"taxa":4279},"curation_status":"SEEDED","description":"This domain family is found in eukaryotes, and is typically between 103 and 119 amino acids in length. There is a conserved HPD sequence motif. There are two completely conserved residues (N and F) that may be functionally important.","id":"Pfam:PF14687","interpro_id":"InterPro:IPR028031","name":"Domain of unknown function (DUF4460)","pfam_id":"PF14687","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4460","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14687"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14687.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"ef7d4c40471f6eedc12bb0635c16272124fea6eb65bef6a085f2f6ed1a6cb2d5"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Rattus norvegicus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4460-pf14687.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14687","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4460-pf14687.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4461-pf14688.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF14688","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4461-pf14688.yaml"}],"pfam_ids":["PF14687","PF14688"],"protein_name":"T-cell activation inhibitor, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MLGSWRAFSEMFCHLRPWRRFCLRKVLPPWLHYSRALSGAEAINALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPTQLTFYIREKTAQNSSEGQEPVSTTGFRAVRFTLHSSDLLSTVLYILNSCSLPVEHVQSLNTNVHSQPLKEATGMPDRPIKWHRSYYSFTGFKDPDEDLEHVSRVETTLTSWLGSNGKGAVKKLKNSLPLRKELDRLKNELSELLQLSDIRWQRGWGVAHRCSQLHSLSRLAQQNLEPLQNAKGCTIVFTDRSGMSALGHVMLGTMDVHHHWTRLFESLPNYFDLQRRMSALEDQISHLLGGIQVVYIEELQPALTLDEYYSLLDTFYNQLQRSRAPPRPQSLSGLQMILSRYAPSLHELGHFNIPALSDPASLQSFMRTKAQQARENMRRREKLKVIENELIQASTRKFSLEKLYKEPSISSRQMVDCCKRLLEQSLPYLHGMHLCVSHFYSVMQDGDLCIPWNWKKGEAMK","sequence_length":505,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e9826816c7d8e438883cbc3352060ffa7e6f2e45871e1c2a4f9e4f14aa6acba6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P0DKR2.json","taxon_id":"10116","uniprot_accession":"P0DKR2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4460-ipr028031.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR028031","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4460-ipr028031.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4461-ipr027989.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR027989","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4461-ipr027989.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4460-pf14687.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14687","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4460-pf14687.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4461-pf14688.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF14688","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4461-pf14688.yaml"}],"pfam_ids":["PF14687","PF14688"],"protein_name":"T-cell activation inhibitor, mitochondrial","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFCHLRPLRRFGLRKVLPHWLHYSRALSGAEAINALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPTQLTFYIREKTAQNSSEGQEPISTTGFRAVRFTLHSSDLLSTVLYILNSCSLPVEHVQSLNTNVHSQPLKEATGMPDRPIKWHRSYYSFTGFKDPDEDLTHVSRVETTLTSWLGSNGKGAVKKLRNSLPLRKELDRLKNELSELLQLSDIRWQRGWGVAHRCSQLHSLSRLAQQNPGPLQNVKGCTVVFTDRSGMSALGHVMLGTMDVHHHWTRLFESLPSYFDLQRRMSALEAQISNLLGGIQVVYIEELQPALTLDQYYSLLHTFYNQLLRSRVPPHPHPQSLSGLQMILSSDRYAPSLHELGHFDIPALSDPASLQSFMRTKAQQARENMTRREKLKVMENELIQASTKQFSLEKLYKEPSISSRQMVDCCKRLLEQSLPYLHGMHLCVSHFYSVMQDGDLCIPWNWKKGEAMK","sequence_length":499,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8bdd1b127969720e53af4a64a2697b0da07edf464cce25ac951b15215899bc33","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q66JZ4.json","taxon_id":"10090","uniprot_accession":"Q66JZ4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4460-ipr028031.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR028031","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4460-ipr028031.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4461-ipr027989.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR027989","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4461-ipr027989.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4460-pf14687.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14687","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4460-pf14687.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4461-pf14688.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF14688","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4461-pf14688.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q8N3R3","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF14687","PF14688"],"protein_name":"T-cell activation inhibitor, mitochondrial","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"0571a119ab91295d92d92a6bf8a8312dd1ebce8fa390fd0ebab6f639ce447f17","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MFCHLRPMRRLCLEKIFPHWFPFSRALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSSSDGQEPFSTSGFRAVKFTLHTRDLLSTVLYILNSCSLSVEHIQSLNTNMHTQPLKEAKRMPDRPIKWDKSYYSFTGFKDPDEDLEQVSRVETTLTSWLDNNGKSAVKKLKNSLPLRKELDRLKDELSHQLQLSDIRWQRSWGIAHRCSQLHSLSRLAQQNLETLKKAKGCTIIFTDRSGMSAVGHVMLGTMDVHHHWTKLFERLPSYFDLQRRLMILEDQISYLLGGIQVVYIEELQPVLTLEEYYSLLDVFYNRLLKSRILFHPRSLRGLQMILNSDRYAPSLHELGHFNIPTLCDPANLQWFILTKAQQARENMKRKEELKVIENELIQASTKKFSLEKLYKEPSISSIQMVDCCKRLLEQSLPYLHGMHLCISHFYSVMQDGDLCIPWNWKNGEAIK","sequence_length":496,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"0571a119ab91295d92d92a6bf8a8312dd1ebce8fa390fd0ebab6f639ce447f17","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N3R3.json","taxon_id":"9606","uniprot_accession":"Q8N3R3","uniprot_release":"2026_03"}],"pfam_id":"PF14687","short_name":"DUF4460","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}