{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14729","protein_label":"Uncharacterized protein YddJ","reviewed":true,"short_name":"DUF4467","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4467-ipr028075.yaml","source_record_id":"InterPro:IPR028075","source_record_label":"Domain of unknown function DUF4467","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P96647","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14729","protein_label":"","reviewed":null,"short_name":"DUF4467","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4467-ipr028075.yaml","source_record_id":"InterPro:IPR028075","source_record_label":"Domain of unknown function DUF4467","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14729","protein_label":"Uncharacterized protein YddJ","reviewed":true,"short_name":"DUF4467","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4467-pf14729.yaml","source_record_id":"Pfam:PF14729","source_record_label":"Domain of unknown function with cystatin-like fold (DUF4467)","source_section":"canonical_examples","taxon_id":"NCBITaxon:224308","taxon_label":"Bacillus subtilis (strain 168)","uniprot_accession":"P96647","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14729","protein_label":"","reviewed":null,"short_name":"DUF4467","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4467-pf14729.yaml","source_record_id":"Pfam:PF14729","source_record_label":"Domain of unknown function with cystatin-like fold (DUF4467)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":60,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":1,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan","domain_architectures":1,"interpro_id":"IPR028075","known_evidence_count":null,"matches":92,"name":"Domain of unknown function with cystatin-like fold (DUF4467)","partial_evidence_count":null,"pfam_id":"PF14729","proteins":92,"proteomes":66,"short_name":"DUF4467","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14729","structures":1,"taxa":112,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14729.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":60,"domain_architectures":1,"matches":92,"proteins":92,"proteomes":66,"structures":1,"taxa":112},"curation_status":"SEEDED","description":"Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan","id":"Pfam:PF14729","interpro_id":"InterPro:IPR028075","name":"Domain of unknown function with cystatin-like fold (DUF4467)","pfam_id":"PF14729","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4467","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14729"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14729.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"904499fadde56e5b97b65d183ccc12132c00353d118e0aa063790af97e021214"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bacillus subtilis (strain 168)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4467-ipr028075.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR028075","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4467-ipr028075.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4467-pf14729.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14729","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4467-pf14729.yaml"}],"pfam_ids":["PF14729"],"protein_name":"Uncharacterized protein YddJ","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKNLFIFLSLMMMFVLTACGGSKYDDAIDDVISQYKEHKGNDTEINIKRENAIVRVYEGGKYIQFAFYMPDNSSRELTTFKYYEKFGDKYEKMTDMPGNGENDRLGLSKKTPDYEEVKGEETELEE","sequence_length":126,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"268dccf2ab1e20c5fb4bd4b0bc2e2146aed9ed4ed839ee9e554c4f9d264cabb8","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P96647.json","taxon_id":"224308","uniprot_accession":"P96647","uniprot_release":"2026_03"}],"pfam_id":"PF14729","short_name":"DUF4467","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}