{"cross_mech":[],"family":{"alphafold_models":1483,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 305 amino acids in length.","domain_architectures":20,"interpro_id":"IPR026755","known_evidence_count":null,"matches":1857,"name":"Protein FAM221A/B","partial_evidence_count":null,"pfam_id":"PF14753","proteins":1721,"proteomes":879,"short_name":"FAM221","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14753","structures":0,"taxa":2775,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14753.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1483,"domain_architectures":20,"matches":1857,"proteins":1721,"proteomes":879,"structures":0,"taxa":2775},"curation_status":"SEEDED","description":"This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 305 amino acids in length.","id":"Pfam:PF14753","interpro_id":"InterPro:IPR026755","name":"Protein FAM221A/B","pfam_id":"PF14753","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"FAM221","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14753"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14753.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"0e72f130d7d23062491ce5d18cab68df7cd1eafaf238ccd765c9afbcc0d8b8ef"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/fam221-pf14753.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14753","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/fam221-pf14753.yaml"}],"pfam_ids":["PF14753"],"protein_name":"Protein FAM221A","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MERLTLPLGGAAAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKRKVLPLRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHRYKQHKTDLEAIPQQCPIDLPCQVTGCQCRAYLYVPLNGSQPIRCRCKHFADQHSAAPGFTCNTCSKCSGFHSCFTCACGQPAYAHDTVVETKQERLAQEKPVGQDIPYAAMGGLTGFSSLAEGYMRLDDSGIGVPSVEFLESPITAVDSPFLKAFQASSSSSPETLTDVGTSSQVSSLRRPEEDDMAFFERRYQERMKMEKAAKWKGKAPLPSATKPS","sequence_length":298,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"faafe209a438c9056372dcfd07eddeb72d5b2d28b5c7e8ad2038f013a49a0c15","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A4D161.json","taxon_id":"9606","uniprot_accession":"A4D161","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/fam221-pf14753.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14753","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/fam221-pf14753.yaml"}],"pfam_ids":["PF14753"],"protein_name":"Protein FAM221B","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEAHEIIEEPHITMDAEKHPPSKDPSAEDLQENHISESFLKPSTSETPLEPHTSESPLVPSPSQIPLEAHSPETHQEPSISETPSETPTYEASLDSPISVVPEKHLTLPPQSRDYVCLSSSDTLKEDLSSESSSNEVPWTRRSTHLSESESLPEHCLSGPSSQVQVDTTEKQEEEAGEVEKGVDASDSTAHTAQPGHQLGNTARPVFPARQTELVEVAKAMHREEFGAQVNNLFQWEKDAALNAIQTGLYIGWRCPHYLWDCFRIGDESRCFCGHLLREHRIISDISVPCKVSQCRCFMFCFIPSRPEEVGEFWLKRRATFDPKAWRAQCRCKHSHEEHAATGPHPCRHHGCCCGCFESNFLCAACDRRWEEHETFFDTQKTRQRGGRPRGTDTVSNWHRPL","sequence_length":402,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8272afdcd415be51659e94789fa2835b339978b9dc4c356bf65e82311abb26eb","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/A6H8Z2.json","taxon_id":"9606","uniprot_accession":"A6H8Z2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/fam221-pf14753.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14753","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/fam221-pf14753.yaml"}],"pfam_ids":["PF14753"],"protein_name":"Protein FAM221B","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEANKTTEGPQDTQDAKEQPSLEDTNAEDLYEATTHETPLQPSSSQKHFQPPEIHLETPASLNPDTKGAEGLQDSSVSGTPPVKSSSSGLLSLPPQLSPQSVTSLEKAIAEIPLEEFGYDSPISKVKEEPLQLSPTANIPEYGSPISEVQKESLEVSPTANIPEYGSPISEVQKEPLEVSSTANIPKYESPVSEVQKEPLEVSPTASIPESSHELTSDKVPQTQVPESEHFPKHSFSESPTQAKEDESTKEGEAGEDELAVGTSKIPAAKPGLRAKKKKEKRAGGVTSRPVVPAKRAELVEMAKAVHREQFDDQVNNLFQWEKDSTLKAIQTGIYIGWRCPHYLWDCFRIGDESKCFCGHLLREHQIISDLSVPCSVSQCRCLMFCFIPSRPEEVGEFWLKKRATFDPKAWRAQCRCKHTHEEHAATGAHPCRHRGCFCPSFESNFLCVACDRRWEEHETFFETGDTRRKGKRPYGANNIKNWHRTY","sequence_length":487,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3a6ede2472257474681b9afc9a8568642452b6ca61b2e96d7c92e6441d3665f2","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8C627.json","taxon_id":"10090","uniprot_accession":"Q8C627","uniprot_release":"2026_03"}],"pfam_id":"PF14753","short_name":"FAM221","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}