{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14771","protein_label":"Proline and serine-rich protein 1","reviewed":true,"short_name":"DUF4476","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4476-ipr028011.yaml","source_record_id":"InterPro:IPR028011","source_record_label":"Domain of unknown function DUF4476","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q5PRE5","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14771","protein_label":"Proline and serine-rich protein 1","reviewed":true,"short_name":"DUF4476","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4476-ipr028011.yaml","source_record_id":"InterPro:IPR028011","source_record_label":"Domain of unknown function DUF4476","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q86XN7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14771","protein_label":"","reviewed":null,"short_name":"DUF4476","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4476-ipr028011.yaml","source_record_id":"InterPro:IPR028011","source_record_label":"Domain of unknown function DUF4476","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14771","protein_label":"Proline and serine-rich protein 1","reviewed":true,"short_name":"DUF4476","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4476-pf14771.yaml","source_record_id":"Pfam:PF14771","source_record_label":"Domain of unknown function (DUF4476)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q5PRE5","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14771","protein_label":"Proline and serine-rich protein 1","reviewed":true,"short_name":"DUF4476","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4476-pf14771.yaml","source_record_id":"Pfam:PF14771","source_record_label":"Domain of unknown function (DUF4476)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q86XN7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14771","protein_label":"","reviewed":null,"short_name":"DUF4476","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4476-pf14771.yaml","source_record_id":"Pfam:PF14771","source_record_label":"Domain of unknown function (DUF4476)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1656,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"","domain_architectures":54,"interpro_id":"IPR028011","known_evidence_count":null,"matches":2159,"name":"Domain of unknown function (DUF4476)","partial_evidence_count":null,"pfam_id":"PF14771","proteins":2065,"proteomes":1503,"short_name":"DUF4476","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14771","structures":0,"taxa":3727,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14771.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1656,"domain_architectures":54,"matches":2159,"proteins":2065,"proteomes":1503,"structures":0,"taxa":3727},"curation_status":"SEEDED","id":"Pfam:PF14771","interpro_id":"InterPro:IPR028011","name":"Domain of unknown function (DUF4476)","pfam_id":"PF14771","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4476","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14771"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14771.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"2c5313c5d838e185ded5db3ae2eb5446a40275518768797a942e2f73f59d197e"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4476-ipr028011.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR028011","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4476-ipr028011.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4476-pf14771.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14771","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4476-pf14771.yaml"}],"pfam_ids":["PF14771"],"protein_name":"Proline and serine-rich protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDKKSFETVLDEIRKAVLTEYKLKAIEYVHGYFSSEQVVDLLRYFSWAEPQLKAMKALQHKMVAVHPAEVVSILSCFTFSKDKLAALELLASNIVDAQNSRPIEDLFRINMSEKKRCKRVLEQASKAGCKAPHAMISSCGTFPGNPYPKGKPSRINGIFPGTPLKKDGEEITNEGKGIAARILGPSKPPPSTYNPHKPVPYPIPPCRPHATIAPSAYNNAGLVPLANVIAPGVPPPPPYTPNPAGTDNEDLSSQSKPTQSQTFSTPASQLFSPHGSSNPSTPAATPVPAVSPAKAVNHPSVSAAATGAGMSATNTALAVFPTPQPNTPNPTVIRTPSVPATPVTSTHSTTPTPVPSVFSGLVPLPGLSATPTLPTQASSISRVTLASSETFASTCAPFSGHSSASSTAGSASNPITAPLSSVFAGLPLPFPPASHSIATPTPSVIASAAGPHGVNSPLLSALKGFLTSNDTHLINSSALPSAVTSGLASLSSLPNRNSDSPASATNKCYPPAAVPAAQRSSTPGLAMFPGLQSPVASATSVAPTLPAQSPLATPSTAVPVSCGSSGSLLHGPHAGGISSAPAAATMPVMIKSEPTSPPPSAFKGPAHPGTPVRGTLGLSGALGRGYPTTSVPISVSTCLNPALSGLSSLSTPLAGSMSLPPHASSTPIAPVFTALPPFTSLTNSFPLPGSPSLNPAVSLAGSSTTTTSAAVHPSSATVRSVLPTSNASPAAFPLNLSTAVPSLFAVTQGPLPTSNPSYPGFPVSSAPSGAPTLPSFPGLQAPSTVAVTPLPVAASAPSPAPVLPGFASAFSSNFNSALVAQAGLSSGLQAAGSSVFPGLLSLPGIPGFSQAPPQSSLQELQHSAAAQSALLQQVHSASALESYPAQADGFPSYPSTPGTPFSLQTGLSQSGWQ","sequence_length":913,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ea988618c78bc0367a2c71d23143a4c3f1ec8e553df62873127513831759b030","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5PRE5.json","taxon_id":"10090","uniprot_accession":"Q5PRE5","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4476-ipr028011.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR028011","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4476-ipr028011.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4476-pf14771.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14771","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4476-pf14771.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q86XN7","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF14771"],"protein_name":"Proline and serine-rich protein 1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"ab32f5cdbab10e4f405013613723141092c9873e8ecd98dd742b88b96f34bab9","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MDKKSFEMVLDEIRKAVLTEYKLKAIEYVHGYFSSEQVVDLLRYFSWAEPQLKAMKALQHKMVAVQPTEVVNILNCFTFSKDKLVALELLASNIIDAQNSRPIEDLFRVNMSEKKRCKRILEQAFKGGCKAPHAMISSCGTIPGNPYPKGRPSRINGIFPGTPLKKDGEECTNEGKGIAARILGPSKPPPSTYNPHKPVPYPIPPCRPHATIAPSAYNNAGLVPLANVIAPPPPPYTPNPVGTENEDLSNPSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVKAINHPSASAAATVSGMNLLNTVLPVFPGQVSSAVHTPQPSIPNPTVIRTPSLPTAPVTSIHSTTTTPVPSIFSGLVSLPGPSATPTAATPTPGPTPRSTLGSSEAFASTSAPFTSLPFSTSSSAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTPVIAGGSTPSVAGPLGVNSPLLSALKGFLTSNDTNLINSSALSSAVTSGLASLSSLTLQNSDSSASAPNKCYAPSAIPTPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSPLATAASASTSVPVSCGSSASLLRGPHPGTSDLHISSTPAATTLPVMIKTEPTSPTPSAFKGPSHSGNPSHGTLGLSGTLGRAYTSTSVPISLSACLNPALSGLSSLSTPLNGSNPLSSISLPPHGSSTPIAPVFTALPSFTSLTNNFPLTGNPSLNPSVSLPGSLIATSSTAATSTSLPHPSSTAAVLSGLSASAPVSAAPFPLNLSTAVPSLFSVTQGPLSSSNPSYPGFSVSNTPSVTPALPSFPGLQAPSTVAAVTPLPVAATAPSPAPVLPGFASAFSSNFNSALVAQAGLSSGLQAAGSSVFPGLLSLPGIPGFPQNPSQSSLQELQHNAAAQSALLQQVHSASALESYPAQPDGFPSYPSAPGTPFSLQPSLSQSGWQ","sequence_length":944,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"ab32f5cdbab10e4f405013613723141092c9873e8ecd98dd742b88b96f34bab9","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q86XN7.json","taxon_id":"9606","uniprot_accession":"Q86XN7","uniprot_release":"2026_03"}],"pfam_id":"PF14771","short_name":"DUF4476","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}