{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14868","protein_label":"FIGNL1-interacting regulator of recombination and mitosis","reviewed":true,"short_name":"DUF4487","source_category":"sequence/repeat/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml","source_record_id":"Pfam:PF14868","source_record_label":"Domain of unknown function (DUF4487)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q3TQQ9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14868","protein_label":"FIGNL1-interacting regulator of recombination and mitosis","reviewed":true,"short_name":"DUF4487","source_category":"sequence/repeat/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml","source_record_id":"Pfam:PF14868","source_record_label":"Domain of unknown function (DUF4487)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10116","taxon_label":"Rattus norvegicus","uniprot_accession":"Q5XI94","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF14868","protein_label":"FIGNL1-interacting regulator of recombination and mitosis","reviewed":true,"short_name":"DUF4487","source_category":"sequence/repeat/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml","source_record_id":"Pfam:PF14868","source_record_label":"Domain of unknown function (DUF4487)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9NSG2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF14868","protein_label":"","reviewed":null,"short_name":"DUF4487","source_category":"sequence/repeat/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml","source_record_id":"Pfam:PF14868","source_record_label":"Domain of unknown function (DUF4487)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1441,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.","domain_architectures":30,"interpro_id":"IPR027902","known_evidence_count":null,"matches":1876,"name":"Domain of unknown function (DUF4487)","partial_evidence_count":null,"pfam_id":"PF14868","proteins":1745,"proteomes":1084,"short_name":"DUF4487","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14868","structures":0,"taxa":3597,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14868.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1441,"domain_architectures":30,"matches":1876,"proteins":1745,"proteomes":1084,"structures":0,"taxa":3597},"curation_status":"SEEDED","description":"This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.","id":"Pfam:PF14868","interpro_id":"InterPro:IPR027902","name":"Domain of unknown function (DUF4487)","pfam_id":"PF14868","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4487","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14868"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14868.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"5c462445f8b995a97dd8faac77b13636dbeddc727da485fb885fc5fbadc4d6b0"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14868","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml"}],"pfam_ids":["PF14868"],"protein_name":"FIGNL1-interacting regulator of recombination and mitosis","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSQDDAEVASGVVLEELSSWSEEMCRRELPSVLPRLLSMYQCSESWIEHIRILKIIVEMFLPHMNHLTLEETLFSQVLPKSIKLFDGMICELTSEARELSSQNLEIQVTIRNILQAMVQVIGGFTGCVRHVCATQKSVFLGSIQSLPSFILHIIKSAFVHCKNSECVYSGRLHLVSDLLQVLFKEAYSLQKQLMGLLDTVCLDPSVDENNALIMVGVIHSLLDICSVISGMDQAFHANTWKFIIKQSLKHHSVIKSQLRHKEIISSLCEDILFSFHSCLQLAEQITQPAAQGNADYRLFQKTLKLCRFFANSLLHYTKECLPFLSDSCCTLHQLYLQIHSKFLSLCAAKTSKAQQEEIASTFLVLLDPLISQLLKSQPFVQAVLASKLALPCELQLPQVLLLVVAMDKLPSQPQDVQTLWSTEDMTRMSILKGIFYNFGQCSGELSLPTHLQGTKGKGQAEVPVTLYQHVCVHLCAFVASFHSSLFPRLDAALLNAVLSTNMSTSLLAMDVWCFLARYGTAKLGAHHVTLVAHLVKSCPGKCVQLTNLSILLKRLLFFMAAPHQVQFIQKFSPKEADNLHLWQYISLQAFDADLRKPVACELVRVCRAQCRKWLSSTRTLAELDSLNTALSVVLTVCNSAGEALDSRQLTAVTEVLGELWTFINVEQIISQPYVQQAFSLLLQLLAFFIQTVDLQLISQVVNVLTSVIKLEPPDHVSLAVLDFISSLGKLYISQTIRDKVLPSLSCILTSLIVNKNWLLEQHTLEAFTQFAEGTKHEEIVPQCLGSEEIKNKVVSFLEKTESVDEAEVATVDNVKQEKGTFWEPAAKVTVEEVKTSAFQPHTKRARRVLPFEEEYRSVFKAAARALETTEFLLKHSLAPAWLLPELEALQGRIEKLKRCVLTG","sequence_length":903,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f12ed637f5f33025d9e5f2b34a9c7b09234933575a1a04404898a9a856e2dba0","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q3TQQ9.json","taxon_id":"10090","uniprot_accession":"Q3TQQ9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Rattus norvegicus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14868","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml"}],"pfam_ids":["PF14868"],"protein_name":"FIGNL1-interacting regulator of recombination and mitosis","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSQNGAVATNGVMLEELSSWPEEICRRELPSVLPRLLSMYQCSESWIEHIRILKIIVEMFLPHMNHLTLEETLFSQILPKTIQLFDGMICELTSEARELSSQNLEIQITIRNILQTMVQIIGSLTGCVHHVCATQESIILGNIHSLPSFILHIIKSTFVHCKNSESVYSGRLHLVSDLLQTLFKEAYSLQKQLMELLDMVCLGPSEDENSILTMVEVIHSLMDICSVISSMDKAFHANTWKFIIKQSLKHQSVIRSQLKHKEIISSLCEDILFSFHSCLQLAEQTTEPAAQDNADYRLFQKTLKLCRFFANSLLHYTKEFLPFLPDSCRTLHQLYLQIYSKFPPCLYTAKISKVQQEEIAGTFLVVLDPLLSQLLKSQSFVQTVLASKLDLPHELQLPQVLLLVVVVDKLPSQPEDVQTLWCTEDMTRMSILKAIFYNFGQFSGELSLPAHLQGVKGKGQAEVPVTLYQRICVHLCTFVASLHPTLFPELDAALLNAVLSTNMSTSLLAMDVWCFLARYGTAELGAHHVTLVAHLIKSCPGRCVQLTNLSVLLRRLFFFMAPAHQVEFIQKFSPREADNLHLWQYISFQALPADLRKQVTCEVTGVCTAQCRKWLSGSHTLAELDSLNTALSVLLTVCNSAGEALDSRQLTAVTEVVGQLWAFINVEQIISQPHVQQAFSLLLQLLAFFIQTVDLQLISQVVNVLTLVIKLEPPDHVSLAVLDFLSSLGKLYISQTLRDKVLPSLSCIVASLMVNRNWLLEQHTLEAFTQFAEGTKHEEIVSQCLGSEEIKNKVVSFLEKTESVGETEAATADNSGEQKTDTFWEPVAKVTLEEAKGSAFQPCTKRARQELLLEEEYRSAFQTATRALETTEALLKHSRAPAWLLSELGALQERIEKLKCCVLRG","sequence_length":905,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ea9d667c6e1421aa63832488ec9bc9fdad7f9de0bb7563b03baec3f924a82612","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5XI94.json","taxon_id":"10116","uniprot_accession":"Q5XI94","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14868","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/duf4487-pf14868.yaml"}],"pfam_ids":["PF14868"],"protein_name":"FIGNL1-interacting regulator of recombination and mitosis","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MFLPHMNHLTLEQTFFSQVLPKTVKLFDDMMYELTSQARGLSSQNLEIQTTLRNILQTMVQLLGALTGCVQHICATQESIILENIQSLPSSVLHIIKSTFVHCKNSESVYSGCLHLVSDLLQALFKEAYSLQKQLMELLDMVCMDPLVDDNDDILNMVIVIHSLLDICSVISSMDHAFHANTWKFIIKQSLKHQSIIKSQLKHKDIITSLCEDILFSFHSCLQLAEQMTQSDAQDNADYRLFQKTLKLCRFFANSLLHYAKEFLPFLSDSCCTLHQLYLQIHSKFPPSLYATRISKAHQEEIAGAFLVTLDPLISQLLTFQPFMQVVLDSKLDLPCELQFPQCLLLVVVMDKLPSQPKEVQTLWCTDSQVSETTTRISLLKAVFYSFEQCSGELSLPVHLQGLKSKGKAEVAVTLYQHVCVHLCTFITSFHPSLFAELDAALLNAVLSANMITSLLAMDAWCFLARYGTAELCAHHVTIVAHLIKSCPGECYQLINLSILLKRLFFFMAPPHQLEFIQKFSPKEAENLPLWQHISFQALPPELREQTVHEVTTVGTAECRKWLSRSRTLGELESLNTVLSALLAVCNSAGEALDTGKQTAIIEVVSQLWAFLNIKQVADQPYVQQTFSLLLPLLGFFIQTLDPKLILQAVTLQTSLLKLELPDYVRLAMLDFVSSLGKLFIPEAIQDRILPNLSCMFALLLADRSWLLEQHTLEAFTQFAEGTNHEEIVPQCLSSEETKNKVVSFLEKTGFVDETEAAKVERVKQEKGIFWEPFANVTVEEAKRSSLQPYAKRARQEFPWEEEYRSALHTIAGALEATESLLQKGPAPAWLSMEMEALQERMDKLKRYIHTLG","sequence_length":853,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"56b28b89526a7a51cd51d9b8ef34d4bcb5dd054da0c4a226b19e0ccb563eecfb","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9NSG2.json","taxon_id":"9606","uniprot_accession":"Q9NSG2","uniprot_release":"2026_03"}],"pfam_id":"PF14868","short_name":"DUF4487","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
