{"cross_mech":[],"family":{"alphafold_models":922,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This domain is found at the N-terminal of MAP10 (Microtubule associated protein 10, also known as MTR120/KIAA1383) from mammals. There are two completely conserved G residues that may be functionally important. It adopts a C2-like fold. MAP10 localises to stabilised MTs during interphase and to the mitotic apparatus during mitosis. It may promote microtubule stability and ensures normal progress of cytokinesis [[cite:PUB00068314]].","domain_architectures":31,"interpro_id":"","known_evidence_count":null,"matches":1162,"name":"Microtubule associated protein 10, N-terminal domain","partial_evidence_count":null,"pfam_id":"PF14924","proteins":1145,"proteomes":585,"short_name":"MAP10_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14924","structures":0,"taxa":2212,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14924.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":922,"domain_architectures":31,"matches":1162,"proteins":1145,"proteomes":585,"structures":0,"taxa":2212},"curation_status":"SEEDED","description":"This domain is found at the N-terminal of MAP10 (Microtubule associated protein 10, also known as MTR120/KIAA1383) from mammals. There are two completely conserved G residues that may be functionally important. It adopts a C2-like fold. MAP10 localises to stabilised MTs during interphase and to the mitotic apparatus during mitosis. It may promote microtubule stability and ensures normal progress of cytokinesis [[cite:PUB00068314]].","id":"Pfam:PF14924","name":"Microtubule associated protein 10, N-terminal domain","pfam_id":"PF14924","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"MAP10_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14924"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14924.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"cccb1654f113fc277dafc1955d633df86869fa644e27d0171b259a8c0003e3d9"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Rattus norvegicus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/disorder/pfam/map10-c-pf14925.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF14925","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/disorder/pfam/map10-c-pf14925.yaml"}],"pfam_ids":["PF14924","PF14925"],"protein_name":"Microtubule-associated protein 10","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAATAAERLFSLELLVDWVRLDSPCFASPAVAFRLLDFPPLLILPPAAPDPEPQRGAITFGRGKACLLRLRPAALRRPRLRAALLQLPAVPTPAPLLLGACDILLVPSVGQRGIFTLRGPEAERVGELALFYRLTDLGRFPPGAPQLRSPLSPACITGSEALEVSEPRTKETSKPCTKDTSARCLQCVSNGRFLEAPEPCAKDTDNWSAGDSDASAVQKSWEEAILHSKASSGDMASAPCSPAPSGRTVSPVSLEVTELDFETNTFCPPPLYYTHLTQEKAPSARVEITIEPQRNEPEDLEDAFPETKPVGPTIRPVKHTRAAIQESPPVLLNLPQMQGPGEANEAPCPPQTEQSTVGAIRQLPLLNALLMELSLLCNQPVANPSQVHPHLAWLYRGEHKGPDPSTKSTSRSESKSNKLSAQENEKLVSPQSTKNPKGKHSKISGSPPPKVTKGRLLYGLTNTLRLRLQQTNPGMLVVHEKREQYRRSQIRAVGPKFRIPSWKGKVSSLAAESQMPPQLPGDTLTDSNGKVSSWAVQSQLPPQLPRDRSLDSYGSFAEGSDTSMLISSGFDESSRTREAKQSHAMKKETVGQSENKTVTSLRAPVSPAVSVIPERSPRSNILRGKWKKQVQSPGLSRQDPAVDKAVGEGIDGKQVKAASAADTNENRPPSRKSSCESTSELQCWDGSTSPCYSEDFCTTENNSRSLPAPDSSTGAEYAQKGSWASKSSEARLSTRKNSSESSSVFTPPFSAGSPVCSQKRSRVLKTHDSLEEASSLSTSDFSSQWTNEKENQADPGSSKIRRRQDRSTKLKVGTGHKSSEKSHSARTSQVSSYEPSNLSELELKAIDDIDSASTGFQEEEDGLGSLRISRQCRDICELVINKLPGYTV","sequence_length":888,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9c6f68a4830035575b3dff86151c317b1b4279fa86704d7a27d73097ce0f74df","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/D3ZAP3.json","taxon_id":"10116","uniprot_accession":"D3ZAP3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/disorder/pfam/map10-c-pf14925.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF14925","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/disorder/pfam/map10-c-pf14925.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/microtubule-associated-protein-10-c-terminal-ipr026679.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR026679","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/microtubule-associated-protein-10-c-terminal-ipr026679.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/map10-n-pf14924.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14924","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/map10-n-pf14924.yaml"}],"pfam_ids":["PF14924","PF14925"],"protein_name":"Microtubule-associated protein 10","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MATTAAGRLFSLELLVDWVRLETGLSPCAASPAVAFRLLDFPPLLVFPPAAPGPEPQRGAISFGRGKACLLRLHPAALRRPRLRAALLQLPVGPTSAPGLVGACDILLVPSLGQRGVFALRGPEAERVGELALFYRLTELGRFSPGVPQLRGPLSPACILDSEALEVSEPRTEETSKPCTKGISARCLQCVSNARLLEGSEPCAKDTNSWSAGDSDASVVQKSWEEAVLHSKASSGDMASAPCSPAPSGKTVSSVSQDVTELDFETNTFCPPPLYYTHLTQEKTPSARVEITIEPQRNEPEDLDDIFPETKLVSPPLRPVKHTRAAVQESPPVLPNLPQTQGPGEANEAPCPPQIEQSPVNAIRQLPLLNALLIELSLLCNQPVASPTQVHPHLAWLYRGEDKGPDPSTKSTSPSESKSNKLSVRENEKLVNPQSKKNPKGKHPKIGGSPPPKVTKGRLLYGLTNTLRLRLQQTNPNMLVVHEKREQYRRSQIQAVGPKLRIPSWKGKVSSSAAESQMSPQLPADTPTDSNGKLPSLAVQSQLPPQLPGDESLDSIGSFEEGSDTSMQIRAGFDESSTTKEVKQSHAMKQEMVDQSENRTIVTALRAPVSPAGSVTPERSLRSNSFGGNWKNKVPSPGLSLQEPTVDKTVDEGKDGRQVKAISAADTSENRPTSRKSSCESISELLYRDGFTSPCYSEDFCTTENNSRSLPAPDSSTGVEHVQKGSRASKSSEARLSTRKNSSDSSSVLTPPFSAGSPVCSHKRSRALKIHDSLEEASSLSTSDFSSQWTNEKENQADPGSSKVMRKGRDSSTKLKVRAGHKSSEKSQSPRTSQVSSYEPSNLSELELKAIDDSDLADFQEEEDGLGSLRISRQCKDICELVINKLPGYTV","sequence_length":891,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"4c67d486ff1f3e346a0d37d101774a069e5b05ee7be9302cd7be76f1b8ab9002","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8BJS7.json","taxon_id":"10090","uniprot_accession":"Q8BJS7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/disorder/pfam/map10-c-pf14925.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF14925","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/disorder/pfam/map10-c-pf14925.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/microtubule-associated-protein-10-c-terminal-ipr026679.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR026679","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/microtubule-associated-protein-10-c-terminal-ipr026679.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/map10-n-pf14924.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14924","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/map10-n-pf14924.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q9P2G4","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF14924","PF14925"],"protein_name":"Microtubule-associated protein 10","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"3ede6fab1fc58a0a686b25986fa141e9ff2bce4b35ffaf3443e9f6535e70a12f","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MAASLSERLFSLELLVDWVRLEARLLPSPAAAVEQEEEEEEKEQGEASSPRGLCPAVAFRLLDFPTLLVYPPDGPGAPAAEPWPGVIRFGRGKSCLFRLQPATLHCRLLRTPLATLLLQLPPGRPTPTPQLLGACDISLATAAHRVVGPAASGCSHRHRGRFPLHNRVGERTGDIALAYRLTDLGSRLLSQLERPLTFTRTGGGAEVSPQTQQERQQLQQPASQPSPKEADKPLGELEIPEAQKDLKEMVKSKAECDNVGSVENGKTNSVVTCSGAGNGRNVSSLNEEVTELDMETNIFCPPPLYYTNLTQEKPPPAQAKITIEPQMNAPEEMDDASPEKKRVNPPAHRSCLKHPSSAAHEHPPMLVNPPHIQNIGATNQTCQTEQNRINTIRQLPLLNALLVELSLLYDQPVTSPAHIHPHLAWLYRTEDKKSPESSAKSTCRSEAKKDKRSVGGCEKSVSLQYKKNQIENYKEDKYSEKSSGALHKRVPKGRLLYGLTNTLRLRLKLTNPDMLVVHEKRELYRKRQSQMLGTKFRIPSSKVKLLSSAEQSQKPQLPEDKYLDSDASFTENSDTSRQISGVFDEPSTSKETKLKYATEKKTVDCSKNRINNVSLEEVVSPANSIIPERLTPTNILGGNVEMKIQSPCVFQQDAVVDRIVDKEIDIRQVKTTDNDILMADISDKRTGKNSCYENISELKYSDDLSSPCYSEDFCTSEDTSRSFKAHDSSSRTENPKHSQYTSKSSDTGVSKKKNSSDRSSILSPPFSAGSPVHSYRKFHISKTQDKSLEEASSISASDLSSTHWTEQKENQIDQNSMHNSEITKRAQDISVKTRSSWKSLEKSQSPQTSQVSSYLPSNVSELNVLDSSTSDHFEEGNDDVGSLNISKQCKDICELVINKLPGYTM","sequence_length":905,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"3ede6fab1fc58a0a686b25986fa141e9ff2bce4b35ffaf3443e9f6535e70a12f","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9P2G4.json","taxon_id":"9606","uniprot_accession":"Q9P2G4","uniprot_release":"2026_03"}],"pfam_id":"PF14924","short_name":"MAP10_N","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
