{"cross_mech":[],"family":{"alphafold_models":1077,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Integrator complex subunit 15 (C7orf26) is likely a component of the Integrator (INT) complex, which is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing [[cite:PUB00100760]].","domain_architectures":27,"interpro_id":"IPR027844","known_evidence_count":null,"matches":1281,"name":"Integrator complex subunit 15","partial_evidence_count":null,"pfam_id":"PF14964","proteins":1234,"proteomes":923,"short_name":"INTS15","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14964","structures":8,"taxa":3205,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14964.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1077,"domain_architectures":27,"matches":1281,"proteins":1234,"proteomes":923,"structures":8,"taxa":3205},"curation_status":"SEEDED","description":"Integrator complex subunit 15 (C7orf26) is likely a component of the Integrator (INT) complex, which is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing [[cite:PUB00100760]].","id":"Pfam:PF14964","interpro_id":"InterPro:IPR027844","name":"Integrator complex subunit 15","pfam_id":"PF14964","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"INTS15","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14964"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14964.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"9fefec41cadd886d2e39eda60ef19d8cb4bf84d7af28a5501cffe8644b932351"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Danio rerio","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ints15-pf14964.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14964","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ints15-pf14964.yaml"}],"pfam_ids":["PF14964"],"protein_name":"Integrator complex subunit 15","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSDIRHALLRRDPLSAAKEVLYHLDISLGSALQSSAGPPAGLEKSTVELVEEFIFHVSKDRNIQSKRMSCVQELQLLEIICSYFQEQSKDAIRQVIFSALFSLQGNKADESRMAMLGKLVSMSIAVCRVPILECAAIWLQRTHSAWCVRLAQVLMEDYCTLVPCAISTLQNICSASPRFCCQLITAVTALYDFSTDELTPPPALLEMLVGWITEDPRLLLLTFINSPLNSSLPLGCLEITPLLGLLRWCVKAPLAYHRGRKSAMTNGHGDGEKGTAYEELYSKLHLSVLQVFLMLQVHLTEKNMFCRLTVLPVESVAALIEEVGRLCEKLAPLLDASHIQLALDRLAQALQVAMATGALLCAREDLRALCSRLPHNNLLQLVMSGPVVQPPPHSSPFQPNMYPHIHPGRPSPLSPHSPHQSTLSSPHSPHTVLTAHPTHPALAPHRPLTAHATHPALSPHAFHPASIAFPYRPIR","sequence_length":475,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b053f1b4f32f09c85da5507ac936c0a4fd4e6e5fedb68a9bf5daab445d4516d2","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q7ZTY6.json","taxon_id":"7955","uniprot_accession":"Q7ZTY6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ints15-pf14964.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14964","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ints15-pf14964.yaml"}],"pfam_ids":["PF14964"],"protein_name":"Integrator complex subunit 15","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGSVELLEEFVFQVPKERGAQPKRLNSLQELQLLEIMCSYFQEQSKDSVRQIIFSSLFSPQGNKADDSRMSLLGKLVSMAVAVCRIPVLECAASWLQRTPVVYCVRLARVLVEDYCCLVPGSVQTLKQIFSASPRFCCQFITSVTALYDLSSDDLIPPLDLLEMIVSWIFEDPRLILITFLNTPIAANLPIGFLELTPLIGLIRWCVKAPLAYKRKKPCLSNGHISHKVAKDSGASTDRDSHLLYSKLHLSVLQVLMTLQLHLTEKNLYGRLGLILFDHMVPLVEEINRLADELNPLNASQEIELALDRLAQALQVAMTSGALLCTRDDLRTLCSRLPHNNLLQLVISGPVQQSPHTALPPGFYPHIHTPPLAYGAVPAHPAAHPALPTHPGHTFISGVTFPFRPIR","sequence_length":448,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"21b0653c0865c515fd1033623458656cdfa5940bd6837a4c5adefa9672b81d84","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8BGA7.json","taxon_id":"10090","uniprot_accession":"Q8BGA7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/ints15-pf14964.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14964","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/ints15-pf14964.yaml"}],"pfam_ids":["PF14964"],"protein_name":"Integrator complex subunit 15","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERSAQPKRLNSLQELQLLEIMCNYFQEQTKDSVRQIIFSSLFSPQGNKADDSRMSLLGKLVSMAVAVCRIPVLECAASWLQRTPVVYCVRLAKALVDDYCCLVPGSIQTLKQIFSASPRFCCQFITSVTALYDLSSDDLIPPMDLLEMIVTWIFEDPRLILITFLNTPIAANLPIGFLELTPLVGLIRWCVKAPLAYKRKKKPPLSNGHVSNKVTKDPGVGMDRDSHLLYSKLHLSVLQVLMTLQLHLTEKNLYGRLGLILFDHMVPLVEEINRLADELNPLNASQEIELSLDRLAQALQVAMASGALLCTRDDLRTLCSRLPHNNLLQLVISGPVQQSPHAALPPGFYPHIHTPPLGYGAVPAHPAAHPALPTHPGHTFISGVTFPFRPIR","sequence_length":449,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1ff8685d2ef51bb88b317f7427ba6b62577e684465e4370bdb7158913584e36a","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q96N11.json","taxon_id":"9606","uniprot_accession":"Q96N11","uniprot_release":"2026_03"}],"pfam_id":"PF14964","short_name":"INTS15","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}