{"cross_mech":[],"family":{"alphafold_models":289,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family (previously DUF4513) represents homologs of Sperm-associated microtubule inner protein 10 (SPMIP10). SPMIP10 is a microtubule inner protein (MIP) part of the axonemal dynein-decorated doublet microtubules (DMTs). It plays a role in the stabilisation of the interacting protomers of TEKTL1 - a tektin-like molecule that forms a filament in the cleft between protofilaments A11 and A12 . In the EM structure of sperm DMTs, SPMIP10 cradles the inter-TEKTL1 interface while interacting with protofilaments A11 and A12 [[cite:PUB00151496]].","domain_architectures":5,"interpro_id":"IPR027965","known_evidence_count":null,"matches":333,"name":"Sperm-associated microtubule inner protein 10","partial_evidence_count":null,"pfam_id":"PF14983","proteins":332,"proteomes":297,"short_name":"SPMIP10-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14983","structures":7,"taxa":1153,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF14983.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":289,"domain_architectures":5,"matches":333,"proteins":332,"proteomes":297,"structures":7,"taxa":1153},"curation_status":"SEEDED","description":"This family (previously DUF4513) represents homologs of Sperm-associated microtubule inner protein 10 (SPMIP10). SPMIP10 is a microtubule inner protein (MIP) part of the axonemal dynein-decorated doublet microtubules (DMTs). It plays a role in the stabilisation of the interacting protomers of TEKTL1 - a tektin-like molecule that forms a filament in the cleft between protofilaments A11 and A12 . In the EM structure of sperm DMTs, SPMIP10 cradles the inter-TEKTL1 interface while interacting with protofilaments A11 and A12 [[cite:PUB00151496]].","id":"Pfam:PF14983","interpro_id":"InterPro:IPR027965","name":"Sperm-associated microtubule inner protein 10","pfam_id":"PF14983","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SPMIP10-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14983"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF14983.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"c37e5cc6470342f73b2e5736d2891c81ebf8b499b34c8357e4ee4bb40f7b4054"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spmip10-like-pf14983.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14983","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spmip10-like-pf14983.yaml"}],"pfam_ids":["PF14983"],"protein_name":"Sperm-associated microtubule inner protein 10","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MASGKDTCPTLPKLTNNCSDESLYKSANKYEEIHLPRFSLKQGMIPRRYVMPWKENMIFRNVNLKQAEVCGIHTGPLEDSLFLNHSERLCHGEDRKVVFQKGPPEIKIADMPLHSPLSRYQSTVISHGFRRRLV","sequence_length":134,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ad6df1f00ef6267c9f5e062bcd391db4545b70892fedbadb30c591441a79c3c6","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q6ZNM6.json","taxon_id":"9606","uniprot_accession":"Q6ZNM6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spmip10-like-pf14983.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF14983","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spmip10-like-pf14983.yaml"}],"pfam_ids":["PF14983"],"protein_name":"Sperm-associated microtubule inner protein 10","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MASEKDDGPALPKLDDDNQTAENTCKPAEEQPQQLRWDDIHLPRFSLKQGMIPTRYVMPWKENMKFRNVNLQQAEACGIYAGPLEDSLFWGYSERLCHGEDRKAVLKKGLPEIKITDMPLHSPLSRYQSTVISHGFRRRLI","sequence_length":141,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"cfbf097c8004499fac84027fcdf25bdc3170852b02517d012ce5a2ddf0fcfd65","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D9I1.json","taxon_id":"10090","uniprot_accession":"Q9D9I1","uniprot_release":"2026_03"}],"pfam_id":"PF14983","short_name":"SPMIP10-like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}