{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15006","protein_label":"Adipose-secreted signaling protein","reviewed":true,"short_name":"DUF4517","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4517-pf15006.yaml","source_record_id":"Pfam:PF15006","source_record_label":"Domain of unknown function (DUF4517)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10116","taxon_label":"Rattus norvegicus","uniprot_accession":"Q4KM45","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15006","protein_label":"Adipose-secreted signaling protein","reviewed":true,"short_name":"DUF4517","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4517-pf15006.yaml","source_record_id":"Pfam:PF15006","source_record_label":"Domain of unknown function (DUF4517)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q9D1K7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15006","protein_label":"Adipose-secreted signaling protein","reviewed":true,"short_name":"DUF4517","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4517-pf15006.yaml","source_record_id":"Pfam:PF15006","source_record_label":"Domain of unknown function (DUF4517)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9GZN8","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF15006","protein_label":"","reviewed":null,"short_name":"DUF4517","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4517-pf15006.yaml","source_record_id":"Pfam:PF15006","source_record_label":"Domain of unknown function (DUF4517)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1160,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"The function of this protein remains unknown. This family of proteins is found in eukaryotes and are typically between 160 and 182 amino acids in length.","domain_architectures":22,"interpro_id":"IPR026794","known_evidence_count":null,"matches":1344,"name":"Domain of unknown function (DUF4517)","partial_evidence_count":null,"pfam_id":"PF15006","proteins":1321,"proteomes":887,"short_name":"DUF4517","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15006","structures":0,"taxa":3033,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15006.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1160,"domain_architectures":22,"matches":1344,"proteins":1321,"proteomes":887,"structures":0,"taxa":3033},"curation_status":"SEEDED","description":"The function of this protein remains unknown. This family of proteins is found in eukaryotes and are typically between 160 and 182 amino acids in length.","id":"Pfam:PF15006","interpro_id":"InterPro:IPR026794","name":"Domain of unknown function (DUF4517)","pfam_id":"PF15006","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4517","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15006"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15006.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"bdd1e702b103e5a7d90abe00d50d5a3403dd16b38fed37fad82b9f04d0918c40"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Rattus norvegicus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4517-pf15006.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15006","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4517-pf15006.yaml"}],"pfam_ids":["PF15006"],"protein_name":"Adipose-secreted signaling protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAAANRGSKPRVRSIRFAAGHDAEGSQSHVHFDEKLHDSVVMVTQESDNSFLVKVGFLKILHRYEITFTLPAVRRLSKDIREAPVHSLHLKLLSVTPIPEGYSIKCEYSAHKEGVLKEEMLLACEGDIGTCVHVTVQARVMDRHHGTPMLLDGVKCVGAELEYDSEHSDWHGFD","sequence_length":174,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c45540beee9d4b5f624e9e631ab10d014fa2568b8cd98d56c28101789da30a2f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q4KM45.json","taxon_id":"10116","uniprot_accession":"Q4KM45","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4517-pf15006.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15006","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4517-pf15006.yaml"}],"pfam_ids":["PF15006"],"protein_name":"Adipose-secreted signaling protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAAANRGSKPRVRSIRFAAGHDAEGSQSHVHFDEKLHDSVVMVTQESDNSFLVKVGFLKILHRYEITFTLPPVRRLSKDIRETPVHSLHLKLLSVTPTSEGYSIKCEYSAHKEGVLKEEMLLACEGDIGTCVRVTVQARVMDRHHGTPMLLDGVKCVGAELEYDSEQSDWLGFD","sequence_length":174,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7b617ce7e4f8c13bcae82b5310277c0698e543d5bad962c8d6e56ffcd6b13410","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D1K7.json","taxon_id":"10090","uniprot_accession":"Q9D1K7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4517-pf15006.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15006","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4517-pf15006.yaml"}],"pfam_ids":["PF15006"],"protein_name":"Adipose-secreted signaling protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAAANKGNKPRVRSIRFAAGHDAEGSHSHVHFDEKLHDSVVMVTQESDSSFLVKVGFLKILHRYEITFTLPPVHRLSKDVREAPVPSLHLKLLSVVPVPEGYSVKCEYSAHKEGVLKEEILLACEGGTGTCVRVTVQARVMDRHHGTPMLLDGVKCVGAELEYDSEHSDWHGFD","sequence_length":174,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6a52fd134d55e48be92e1d600e08b8c5b71665ec4c41fc85bcf4d342bcde4f06","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q9GZN8.json","taxon_id":"9606","uniprot_accession":"Q9GZN8","uniprot_release":"2026_03"}],"pfam_id":"PF15006","short_name":"DUF4517","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
