{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15057","protein_label":"von Willebrand factor A domain-containing protein 3B","reviewed":true,"short_name":"DUF4537","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml","source_record_id":"InterPro:IPR032770","source_record_label":"Domain of unknown function DUF4537","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q502W6","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15057","protein_label":"Uncharacterized protein C11orf16 homolog","reviewed":true,"short_name":"DUF4537","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml","source_record_id":"InterPro:IPR032770","source_record_label":"Domain of unknown function DUF4537","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q9JJR6","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15057","protein_label":"Uncharacterized protein C11orf16","reviewed":true,"short_name":"DUF4537","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml","source_record_id":"InterPro:IPR032770","source_record_label":"Domain of unknown function DUF4537","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9NQ32","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF15057","protein_label":"","reviewed":null,"short_name":"DUF4537","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml","source_record_id":"InterPro:IPR032770","source_record_label":"Domain of unknown function DUF4537","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15057","protein_label":"von Willebrand factor A domain-containing protein 3B","reviewed":true,"short_name":"DUF4537","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4537-pf15057.yaml","source_record_id":"Pfam:PF15057","source_record_label":"Domain of unknown function (DUF4537)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q502W6","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15057","protein_label":"Uncharacterized protein C11orf16 homolog","reviewed":true,"short_name":"DUF4537","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4537-pf15057.yaml","source_record_id":"Pfam:PF15057","source_record_label":"Domain of unknown function (DUF4537)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q9JJR6","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15057","protein_label":"Uncharacterized protein C11orf16","reviewed":true,"short_name":"DUF4537","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4537-pf15057.yaml","source_record_id":"Pfam:PF15057","source_record_label":"Domain of unknown function (DUF4537)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q9NQ32","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF15057","protein_label":"","reviewed":null,"short_name":"DUF4537","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/duf4537-pf15057.yaml","source_record_id":"Pfam:PF15057","source_record_label":"Domain of unknown function (DUF4537)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15057","protein_label":"von Willebrand factor A domain-containing protein 3B","reviewed":true,"short_name":"DUF4537","source_category":"sequence/domain/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/pfam/vwa-3-pf13768.yaml","source_record_id":"Pfam:PF13768","source_record_label":"von Willebrand factor type A domain","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q502W6","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":913,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":3},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.","domain_architectures":34,"interpro_id":"IPR032770","known_evidence_count":null,"matches":1644,"name":"Domain of unknown function (DUF4537)","partial_evidence_count":null,"pfam_id":"PF15057","proteins":1387,"proteomes":542,"short_name":"DUF4537","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15057","structures":0,"taxa":1938,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15057.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":913,"domain_architectures":34,"matches":1644,"proteins":1387,"proteomes":542,"structures":0,"taxa":1938},"curation_status":"SEEDED","description":"The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.","id":"Pfam:PF15057","interpro_id":"InterPro:IPR032770","name":"Domain of unknown function (DUF4537)","pfam_id":"PF15057","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4537","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15057"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15057.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"7d4bd6de4be550bca89893579c34569d5caa45e3945f67ee0067955baff1d5b1"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032770","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4537-pf15057.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15057","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4537-pf15057.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/vwa-3-pf13768.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF13768","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/vwa-3-pf13768.yaml"}],"pfam_ids":["PF13768","PF15057"],"protein_name":"von Willebrand factor A domain-containing protein 3B","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEKSGPSSTISEQQLQRQEGWINTKTDLAEQSLISSEKWLQLHGLKSNKLTLKQILSQIGFPHCEDYVASLGRPVASRYADGLFPQLYRAEDGRVYNLTAKSELIYQFVEHLTQAVESYKQRMDWLTSKSRQIFGVILEQCVTIVLDFGGILEGELDLCREALTMVLQEQVAHITEFNIIRVSQEPVKWQENATPVTEQSIATAISWVEKLTVELTVSEAGRLDALLEAGRDKTIESIYYFVVGDVPEESKELLLQRALEIPCPVYTVSFNARGEGTIAFLKDLSAKTHSRFHAFAERTECVEFPAFSTKDGDNVMTWNSRKLKGKLPPGAGVREDVFLVWQEMEEACSTLAQIQRLVAEPPKPDVATVDCESETTSVEIASNPEDTWDSKTWLQKYGLKAQKLSLYDVLADCSFRHADGVVDIKAKPENESVQTSAETNKKTVHAKYCSRFVHAPWKDGSLVHVNITKEKCKWYSERIHTALARIRRRIKWLQDGSQSLFGRLHNDCIYILIDTSHSMKSKLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDIKIGSSTNTLSALKTAFADKETQAIYLLTDGRPDQPPETVIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTGGEFHFYNFGCKDPTPPEAVQNEDLTLLVKEMEQGHSDLEKMQDLYSESLIMDWWYNAEKDGDSKHQKEICSMISTPEKCAKPQSDVDSTQTSSLNMLKGPWGLSDQKVQKKKVLHAESTKTSLLRSQMSSLRSSACSERKDGLSNASSRRTALSDKEMSILLAEEWLDDKSSEKVTREGSQVYDHDSSDVSSENWLKTYGLVAKKLTLMDALSVAAVPHSSTYVPVLDKHVVSKVFDEVFPLAHVCNDTNKMTLINPQGAKLNIYKRKVEQAIQSYEKRLNKIVWRALSQEEKEKLDANKPIQYLENKTVLNQALERLNWPISLKELSMLESEILAGKMYIQQAMELQEAAKKNYANKAPGEQQKLQGNPTKKTKSKRPDPLKGQKVIARCDENGFYFPGVVKKCVSRTQALVGFSYGDTKVVSTSFITPVGGAMPCPLLQVGDYVFAKIVIPKGFDFYVPAIVIALPNKHVATEKFYTVLKCNNRREFCPRSALIKISQNKYALSCSHIKSPPIPEDPEVEDVEARNSAFLFWPLKEADTQDSREPRREKPRRKKRPAKQPLQQAAPSDSDGSSHGISSHGSCQGTHPEPRTAHLHFPAAGRLGLSSHAIIATPPPRAALPCTLQATHSSKGLRSVPETL","sequence_length":1294,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c0735888e8d17da9ade8f90b096f3c616ea8661436b8efd7095ecc61388e8a84","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q502W6.json","taxon_id":"9606","uniprot_accession":"Q502W6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032770","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4537-pf15057.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15057","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4537-pf15057.yaml"}],"pfam_ids":["PF15057"],"protein_name":"Uncharacterized protein C11orf16 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MQPSASPGLPLPKYCSVATTVKAPDLHGAVPPWDMSFTCPFATQAPWLATHCTFTRCTACCPCLHTVDRPWPGLRWLGRVGAAGGSWVLARKEPDGFYYLAQIKAAPELEKRGALVVEFEAPLVTGLELPAQQQRVVFPEDVIQFSPSVPHSLQLGDKVLAPWEPGQQRYGPGTVLVGLKKQKGQRASKEKEITVHFWNGKTTKVPLGSVRWVPPTVWKKAVERLQAPHTRDCHSSCLWVPHCSQLGPRAGCTTHRHPLDSSFLCPPCLSCACCQLQCQSSCPLVGPSWWPLTRTSELTTRKLPEPEVKPTAQLLPLQGPKEEPVAELSYNMFSSSSSSSEEENSESHLEMGLPLRQMVSRAVNTDPILSETTSLQQYSPHKPEWRYWRRNGPEPPPGKPGR","sequence_length":402,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"888a98939d95ea57bb2c55bfb65d65a471a8bbf6506edebce5ecd628ba463b4b","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9JJR6.json","taxon_id":"10090","uniprot_accession":"Q9JJR6","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032770","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4537-ipr032770.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/duf4537-pf15057.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15057","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/duf4537-pf15057.yaml"}],"pfam_ids":["PF15057"],"protein_name":"Uncharacterized protein C11orf16","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MESSTGPRMPLLKYCSVATSLKAPGWDGAAPPWDLSFTYPFALQAPWLTGHKPLARHASSCPCLHVADPAWQGPGWLGRAGDAANTWVLARREADGFYYRAQIKATPELERQGVLLVEFEAPLVAGPKLPAQQQRVVLEEDVIPLSPSVGYSLRPGDKVLALWEPGQQQYGPGTVLLGLEMRDPQRASKEKEITVHFWNGKAAKVPLGGVQSVSLTIWKKAVERLHKSFTREHPRPLHWAPCCSLLGPITGRITNELPPDAPFLCPLCHHHACCQLLCQGCLCGCPPCGTTWWPLTRTSEVMARELPELEPTAQLLPLEGPKEEKVAMHAPLAVSSSSSSSCEQDGVENDLEMGPPQRLMVNSAVNTDPIFLEMPLRQSGLCQPEWRYWKRNGPEPCLGKPGTRYSNICKEEKDHKQQRAQTAVVGTTKELVSKATHMKPPRTPPGEAEHRKRSQSLAICQWNKNSR","sequence_length":467,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8b96ac7fdf81678ea3bd65df3263ff4b2e96dc1f6792e957164484d6d3240ebc","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q9NQ32.json","taxon_id":"9606","uniprot_accession":"Q9NQ32","uniprot_release":"2026_03"}],"pfam_id":"PF15057","short_name":"DUF4537","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
