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Members of this family contain a conserved KLHRDDR sequence motif.","domain_architectures":13,"interpro_id":"IPR027901","known_evidence_count":null,"matches":745,"name":"Cilia and flagella associated protein 90","partial_evidence_count":null,"pfam_id":"PF15074","proteins":741,"proteomes":616,"short_name":"CFAP90","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15074","structures":8,"taxa":2233,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15074.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":624,"domain_architectures":13,"matches":745,"proteins":741,"proteomes":616,"structures":8,"taxa":2233},"curation_status":"SEEDED","description":"This family represents the homologues of Cilia and flagella associated protein 90 (CFAP90, also known as C5orf49). CFAP90 is a microtubule inner protein (MIP) part of the doublet microtubules (DMTs) in cilia and sperm axoneme [[cite:PUB00103594],[cite:PUB00151496]]. It belongs to the core-MIPs and binds to protofilament B09 in the sperm DMTs. Members of this family contain a conserved KLHRDDR sequence motif.","id":"Pfam:PF15074","interpro_id":"InterPro:IPR027901","name":"Cilia and flagella associated protein 90","pfam_id":"PF15074","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"CFAP90","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15074"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15074.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"74992557bcccf8c6828a76af9f6776ae7b38522400d92a5fa551c8385bbddb92"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cfap90-pf15074.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15074","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cfap90-pf15074.yaml"}],"pfam_ids":["PF15074"],"protein_name":"Cilia- and flagella-associated protein 90","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEDDEEETTASTLRGKPRPPPVSAQSAFSYIPPRRLDPKEHSYYYRPARTGIISLYDCIFKRRLDYDQKLHRDDREHAKSLGLHVNEEEQERPVGVLTSSVYGKRINQPIEPLNRDFGRANHVQADFYRKNDIPSLKEPGFGHIAPS","sequence_length":147,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b21eb1e3be29015bdb117ee0245ebb41fd406a4d918fea955e86e7be92c078db","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A4QMS7.json","taxon_id":"9606","uniprot_accession":"A4QMS7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/cfap90-pf15074.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15074","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/cfap90-pf15074.yaml"}],"pfam_ids":["PF15074"],"protein_name":"Cilia- and flagella-associated protein 90","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEELAKKERRAMDPGGLKKEGKVEEEAGKEEGREEEGGEEEEVTSETLRGKPRPLPISALPAFSYIPPRHQGPKERSYFSREGQTGIVSLYDCVFKRRLDYNQKLHRDDREHAKNLGLHINEEEQERTVPVLMSSVYGKRINQPIEPLNRDYGHVSHVKTDFYRKNEIPSIKGPGFGHINPA","sequence_length":182,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f5991126a1646e89919df0bca74aff9ea1ab87efccee4159ae7ca74bc1a47432","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9DAR0.json","taxon_id":"10090","uniprot_accession":"Q9DAR0","uniprot_release":"2026_03"}],"pfam_id":"PF15074","short_name":"CFAP90","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}