{"cross_mech":[],"family":{"alphafold_models":357,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family (previously DUF4542) represents the homologs of Sperm microtubule associated protein 1 (SPMAP1 also known as C17orf98). These proteins contain a conserved IPPYN sequence motif. The EM structure of sperm DMTs shows that SPMAP1 interacts directly with the tubulin lattice at the A-tubule seam (between protofilaments A09/A10) where outer dense fibers (ODFs) are connected to dynein-decorated doublet microtubules (DMTs) [[cite:PUB00151496]].","domain_architectures":13,"interpro_id":"IPR028027","known_evidence_count":null,"matches":423,"name":"Sperm microtubule associated protein 1","partial_evidence_count":null,"pfam_id":"PF15075","proteins":404,"proteomes":319,"short_name":"SPMAP1-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15075","structures":2,"taxa":1159,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15075.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":357,"domain_architectures":13,"matches":423,"proteins":404,"proteomes":319,"structures":2,"taxa":1159},"curation_status":"SEEDED","description":"This family (previously DUF4542) represents the homologs of Sperm microtubule associated protein 1 (SPMAP1 also known as C17orf98). These proteins contain a conserved IPPYN sequence motif. The EM structure of sperm DMTs shows that SPMAP1 interacts directly with the tubulin lattice at the A-tubule seam (between protofilaments A09/A10) where outer dense fibers (ODFs) are connected to dynein-decorated doublet microtubules (DMTs) [[cite:PUB00151496]].","id":"Pfam:PF15075","interpro_id":"InterPro:IPR028027","name":"Sperm microtubule associated protein 1","pfam_id":"PF15075","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SPMAP1-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15075"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15075.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"dde30b676fc039c0732530c09dcf0a8c171a63c6f2071ed018217605c2644897"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spmap1-like-pf15075.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15075","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spmap1-like-pf15075.yaml"}],"pfam_ids":["PF15075"],"protein_name":"Sperm microtubule associated protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAYLSECRLRLEKGFILDGVAVSTAARAYGRSRPKLWSAIPPYNAQQDYHARSYFQSHVVPPLLRKTDQDHGGTGRDGWIVDYIHIFGQGQRYLNRRNWAGTGHSLQQVTGHDHYNADLKPIDGFNGRFGYRRNTPALRQSTSVFGEVTHFPLF","sequence_length":154,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6e4c90dea4174d4df6459f06e4fcf98e4924652672eee512549b600631e331ce","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A8MV24.json","taxon_id":"9606","uniprot_accession":"A8MV24","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spmap1-like-pf15075.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15075","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spmap1-like-pf15075.yaml"}],"pfam_ids":["PF15075"],"protein_name":"Sperm microtubule associated protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MACCYNSPRRLEKSFVLDGVAVSTMAQAYSIMRPKLWSAIPPYNPQLDHHSRRYFRSRVVPPILRKTDQDHGGTGRDGWIVDYFHIFGQGQRYLNRRNWAGAGHSLQQVSGHDYYNSNPKAITTGLNGRFGYRRNTPALRQHTSVFGEVTPFPIF","sequence_length":155,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"8b6199bb18e2e6caae26d91aafd88cee599b0f1219b47bbd0a55a1746449964d","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9DAQ5.json","taxon_id":"10090","uniprot_accession":"Q9DAQ5","uniprot_release":"2026_03"}],"pfam_id":"PF15075","short_name":"SPMAP1-like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
