{"cross_mech":[],"family":{"alphafold_models":499,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"Membrane-anchored junction protein (MAJIN) is a meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. It is a component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes [[cite:PUB00077546]].","domain_architectures":11,"interpro_id":"IPR027816","known_evidence_count":null,"matches":668,"name":"Membrane-anchored junction protein","partial_evidence_count":null,"pfam_id":"PF15077","proteins":583,"proteomes":394,"short_name":"MAJIN","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15077","structures":3,"taxa":1419,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15077.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":499,"domain_architectures":11,"matches":668,"proteins":583,"proteomes":394,"structures":3,"taxa":1419},"curation_status":"SEEDED","description":"Membrane-anchored junction protein (MAJIN) is a meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. It is a component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes [[cite:PUB00077546]].","id":"Pfam:PF15077","interpro_id":"InterPro:IPR027816","name":"Membrane-anchored junction protein","pfam_id":"PF15077","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"MAJIN","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15077"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15077.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"db395cdeaca21fd5fec95a40e607a956ea51d3f917cd3ee82a1a2f94720a4702"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/majin-pf15077.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15077","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/majin-pf15077.yaml"}],"pfam_ids":["PF15077"],"protein_name":"Membrane-anchored junction protein","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSLKPFTYPFPETRFLHAGPNVYKFKIRYGKSIRGEEIENKEVITQELEVPVEKKAVGAVMRKRKHMDEPSSPSRPGLDRAKIGTSSQGPSKKKPPVETRRNRERKTQQGLQETLASDITDVQKQDSEWGHSLPGRIVPPLQHNSPPPKERAATGFFGFLSSLFPFRYFFRKSSHS","sequence_length":176,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d7452b1e5125c9a7d5bde7a2e7f39737cf986bc816cb680b0b43de93c48013c1","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q3KP22.json","taxon_id":"9606","uniprot_accession":"Q3KP22","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/meiotic-attachment-of-telomere-to-nuclear-envelope-go0070197.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0070197","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/meiotic-attachment-of-telomere-to-nuclear-envelope-go0070197.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/majin-pf15077.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15077","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/majin-pf15077.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q9D992","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF15077"],"protein_name":"Membrane-anchored junction protein","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"60f043255a9377fc9728ea568a532ebc200bcce4359f27323ff28db8fde4f182","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIEDKEVIVQELEDSIRAVLANMDSLQPFVTEHFIVFPYKSKWERVSHLKFKHGESILTPYPFVFTLYIEMKWFAEDLPSGKPADDIPLELVLAETEAEEATMRKWKRKLMEEPSSPSRQGPHRAKMETSSEASSNKKPLKESKRSTDEEAQQEYQDTPASNAIAVKEQDAALGHGLQGLVVPPLQHSSPPPPKEPGARGFLGFLSALFPFRYFFKKSGQ","sequence_length":256,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"60f043255a9377fc9728ea568a532ebc200bcce4359f27323ff28db8fde4f182","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D992.json","taxon_id":"10090","uniprot_accession":"Q9D992","uniprot_release":"2026_03"}],"pfam_id":"PF15077","short_name":"MAJIN","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}