{"cross_mech":[],"family":{"alphafold_models":487,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family (previously DUF4555) includes the homologs of human sperm-associated microtubule inner protein 4 (SPMIP4) that is found predominantly in testis [[cite:PUB00151495]]. SPMIP4 is a microtubule inner protein (MIP) part of the axonemal dynein-decorated doublet microtubules (DMTs). Members of this family adopt rather extended conformation and contain a single or multiple Mn motifs. Each Mn motif consists of a 5- to 6-residue helix flanked by a Tyr/Phe residue on one end and by a Ser/Thr on the other that binds the shoulder of the alpha-tubulin S9/S10 loop [[cite:PUB00151502]]. Members of this family are likely to stabilise the microtubule structure in the sperm flagella [[cite:PUB00151496]].","domain_architectures":8,"interpro_id":"IPR027886","known_evidence_count":null,"matches":610,"name":"Sperm-associated microtubule inner protein 4","partial_evidence_count":null,"pfam_id":"PF15093","proteins":575,"proteomes":397,"short_name":"SPMIP4-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15093","structures":3,"taxa":1493,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15093.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":487,"domain_architectures":8,"matches":610,"proteins":575,"proteomes":397,"structures":3,"taxa":1493},"curation_status":"SEEDED","description":"This family (previously DUF4555) includes the homologs of human sperm-associated microtubule inner protein 4 (SPMIP4) that is found predominantly in testis [[cite:PUB00151495]]. SPMIP4 is a microtubule inner protein (MIP) part of the axonemal dynein-decorated doublet microtubules (DMTs). Members of this family adopt rather extended conformation and contain a single or multiple Mn motifs. Each Mn motif consists of a 5- to 6-residue helix flanked by a Tyr/Phe residue on one end and by a Ser/Thr on the other that binds the shoulder of the alpha-tubulin S9/S10 loop [[cite:PUB00151502]]. Members of this family are likely to stabilise the microtubule structure in the sperm flagella [[cite:PUB00151496]].","id":"Pfam:PF15093","interpro_id":"InterPro:IPR027886","name":"Sperm-associated microtubule inner protein 4","pfam_id":"PF15093","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SPMIP4-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15093"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15093.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"5d3904131b4e4238f7cc6132258bf749fe6aec505dda7656b446c5b7a06ee60a"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spmip4-like-pf15093.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15093","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spmip4-like-pf15093.yaml"}],"pfam_ids":["PF15093"],"protein_name":"Sperm-associated microtubule inner protein 4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEVIHGRPYCCRELEGADILSNTFYSNELHNPLQTVTRPTASEDRYQELRESLQQCRLPWGAEREYGGIIPISLPEDHRPKYEPPRVMGKGHQHYGFGGETWPRKLPVEQFYYLTQNKKSDVYGNDSLIPKPPNSTVGEICLPYPIEHPYHTHICRGAMFPTFTSPEDLYTGIKARTQQPFPPTVPTKAYDSTVLKTRGNPYRYELIDIPMDSKKKALTWPGQGVYYDFPRGVEKNKPVFYPKPPKTFAPNTSLNSWDPICSAKEANIQRNLERSHWLTSYTHDFTGLGPMDPLELDDYHEKMVAELTRKIGFDPEPQEKFHPVFKPPRPLEGRIARLIQNRRSLEAIVQQRPRSCPDCTPRVLCNFHTFVPSSKEMVALSDNIPAGVTHKNQDIEEKIIEEQSLLSTYELPSCYPTKDLTSIYDIKPFPKITDTKKTEDLYWRQQSLKTQPTPYCKPDHWIHYENLKSPLRDQYNMCPDPVSLSKPSVLQNKQDTEAFTLEHFLSKPEEELFLNMENNEETRPVLGWIPRAGVTKPQTNLLELKNSFSKTGAQKRFHKSILEDHKDLRDNEHSGMKHQFYGHNSYYFYN","sequence_length":590,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e2612144bfe9e0999692eccf7d41253e9a82cf4f6e9329263c0df5ea6a519822","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N865.json","taxon_id":"9606","uniprot_accession":"Q8N865","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/spmip4-like-pf15093.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15093","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/spmip4-like-pf15093.yaml"}],"pfam_ids":["PF15093"],"protein_name":"Sperm-associated microtubule inner protein 4","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEVIHGRPHCCRNLEGADILSNTFYSNGLHTPYETTIRPTASQARYQELREALPQCRLRWGADREYGGVLPVSLPEEHRPKCEPPRLMSKGHQHYGFGGEIWPKKLPIEQYYYMTQNKKSDVYGNDSLLPKPPNSAVKEICSPYPIEHPYHTHISRGSVFPTFTSPKDLYTGIKARTQQPFPPTVPTKACDTTILKTRGNPYRYELLDFPMDSKKKALTWPGQGVYYDFPKFVEKNKPVFYPKPPKTFAPNSSVNPWDTMSSAKDANIQRNLERSHWLTSYAHDFTGLGPMSPLELDDYHEKELAELTGQIGFDPQPQEKFHPALKTPRPLDGRIARLTQNQRPLEATVQIPPPCPDCTPRVLCAFHTFIPTSAEIMAMNNNLLSGITHKNQDVEEKIKEEQGLMSTCPLPTCYESKDLTSLYDVQSFPKITDTKKTDDLYWRQLEMKPLPISCSKSNHYIDYEPLKSAYRDPYAMCPNPVRLSKSNILQNKTDTADFTFDNFLSKPEFLGMNMESNEETRPLLDWIPRAGVPKHHSNLRNLRNTFSKSMAQKRLHNSIQEEQKDLRDKLQCGMRHQFFGYNGHHFYN","sequence_length":588,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"db67f0cf4aa3362b29423399f2090071ce48ceb06a7014183f8c9664e7819937","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9D5Y0.json","taxon_id":"10090","uniprot_accession":"Q9D5Y0","uniprot_release":"2026_03"}],"pfam_id":"PF15093","short_name":"SPMIP4-like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}