{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15145","protein_label":"Leucine-rich single-pass membrane protein 1","reviewed":true,"short_name":"DUF4577","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4577-pf15145.yaml","source_record_id":"Pfam:PF15145","source_record_label":"Domain of unknown function (DUF4577)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9913","taxon_label":"Bos taurus","uniprot_accession":"A5PK14","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15145","protein_label":"Leucine-rich single-pass membrane protein 1","reviewed":true,"short_name":"DUF4577","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4577-pf15145.yaml","source_record_id":"Pfam:PF15145","source_record_label":"Domain of unknown function (DUF4577)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q3UQS2","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15145","protein_label":"Leucine-rich single-pass membrane protein 1","reviewed":true,"short_name":"DUF4577","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4577-pf15145.yaml","source_record_id":"Pfam:PF15145","source_record_label":"Domain of unknown function (DUF4577)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q8N8F7","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF15145","protein_label":"","reviewed":null,"short_name":"DUF4577","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4577-pf15145.yaml","source_record_id":"Pfam:PF15145","source_record_label":"Domain of unknown function (DUF4577)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":572,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":1},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"The function of this family of proteins, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically 128 amino acids in length.","domain_architectures":6,"interpro_id":"IPR028099","known_evidence_count":null,"matches":611,"name":"Domain of unknown function (DUF4577)","partial_evidence_count":null,"pfam_id":"PF15145","proteins":605,"proteomes":545,"short_name":"DUF4577","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15145","structures":0,"taxa":1606,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15145.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":572,"domain_architectures":6,"matches":611,"proteins":605,"proteomes":545,"structures":0,"taxa":1606},"curation_status":"SEEDED","description":"The function of this family of proteins, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically 128 amino acids in length.","id":"Pfam:PF15145","interpro_id":"InterPro:IPR028099","name":"Domain of unknown function (DUF4577)","pfam_id":"PF15145","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4577","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15145"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15145.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"27604b1970b00a3e069313d10febb473e2ba0cd97726043995bb230d022842ea"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Bos taurus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4577-pf15145.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15145","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4577-pf15145.yaml"}],"pfam_ids":["PF15145"],"protein_name":"Leucine-rich single-pass membrane protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MKRSSQDSGSRSIPEDRKLYVVDSINDLNKLNLCPAGSQQLFPLEEKLQDISTDSGNGSRSLFLVGLIIVLIISLALVSFVIFLIVQTENKMEDVSRRLAAEGKDIDDLKKINSIIVKRLNQLDSEQS","sequence_length":128,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"daa1aaf9d6ff3c08d5348dd9d6b5ab0e7d5a4e6727e5ccd24e8402670d606c52","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A5PK14.json","taxon_id":"9913","uniprot_accession":"A5PK14","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4577-pf15145.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15145","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4577-pf15145.yaml"}],"pfam_ids":["PF15145"],"protein_name":"Leucine-rich single-pass membrane protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTHSSQDAGSHGIQEEGRLYVVDSINDLNKLSLCPMESQHLFSLEDKIPNAGTAPGNGRRGLFFVGLLLVLTVSLALVFFAIFLIIQTGNQMEDVSRRLTAEGKDIDDLKKINNMIVKRLNQLDSEQN","sequence_length":128,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"ab5f9e25ed499582c4a4a0d88652508c66dad33056af8c7640e4db01f11d6a57","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q3UQS2.json","taxon_id":"10090","uniprot_accession":"Q3UQS2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4577-pf15145.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15145","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4577-pf15145.yaml"}],"pfam_ids":["PF15145"],"protein_name":"Leucine-rich single-pass membrane protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTHSSQDTGSCGIQEDGKLYVVDSINDLNKLNLCPAGSQHLFPLEDKIPVLGTNSGNGSRSLFFVGLLIVLIVSLALVFFVIFLIVQTGNKMDDVSRRLTAEGKDIDDLKRINNMIVKRLNQLNQLDSEQN","sequence_length":131,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1e107c1330083adb4fd7dcc553350af6a09f33ca7595bd48f7a2e44abf367026","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8N8F7.json","taxon_id":"9606","uniprot_accession":"Q8N8F7","uniprot_release":"2026_03"}],"pfam_id":"PF15145","short_name":"DUF4577","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
