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It is also required for the localization of TEX11 and MSH4 to recombination intermediates [[cite:PUB00096701]].","domain_architectures":5,"interpro_id":"IPR027857","known_evidence_count":null,"matches":558,"name":"Protein SPO16 homolog","partial_evidence_count":null,"pfam_id":"PF15162","proteins":556,"proteomes":477,"short_name":"SCRE","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15162","structures":0,"taxa":1717,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15162.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":485,"domain_architectures":5,"matches":558,"proteins":556,"proteomes":477,"structures":0,"taxa":1717},"curation_status":"SEEDED","description":"This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. 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It is also required for the localization of TEX11 and MSH4 to recombination intermediates [[cite:PUB00096701]].","id":"Pfam:PF15162","interpro_id":"InterPro:IPR027857","name":"Protein SPO16 homolog","pfam_id":"PF15162","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SCRE","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15162"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15162.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"629773dc7f13ce336f1b3b9b7fed86d3b4488c6fc8a02ddfbd55c7287ddc5270"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/scre-pf15162.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15162","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/scre-pf15162.yaml"}],"pfam_ids":["PF15162"],"protein_name":"Protein SPO16 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAMDERRGKERVQWTTTIIISSSLKSYEIATALENRSHKVRYSDTLESGSIVFSLSGVAFLLMDAKECMTSAEEIFVTKIEKFINIHQNSFLVLFAPLHGPEEWSLMFRIHQRFLGSNLRILPVHNTVNALDLMCTIAKTTSKPHIDSICYRMITTKAYIIEQSPVWRTLQKIKLSSDSVSADSGE","sequence_length":186,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"78e2048bfd956b388439c62cf0ff62ae858eb341875290fa9e0ebd6477aa0228","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/Q3KQP7.json","taxon_id":"10090","uniprot_accession":"Q3KQP7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/scre-pf15162.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15162","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/scre-pf15162.yaml"}],"pfam_ids":["PF15162"],"protein_name":"Protein SPO16 homolog","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MAESGKEKIKWTTTIIISSSLKSYEVATALENRSHKVRYSDSVENGSIIFSLSGVAFLLMDTKECLLSTEEIFLAKIEKFINIHQNSFLVLSAALHGPEEWKLMFRIQQRFLGCNLRILPVHNTVNAINLMCTIAKTTSKPYIDSICYRMITAKAYIIEQSPVWKTLQKIKLNSDSVNPN","sequence_length":180,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"234d0de53bdfa7f209b9d969aa9e1c2758df052e3cf550c6497b85007f5cc744","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5VVC0.json","taxon_id":"9606","uniprot_accession":"Q5VVC0","uniprot_release":"2026_03"}],"pfam_id":"PF15162","short_name":"SCRE","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}