{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15252","protein_label":"Inhibitory synaptic factor 1","reviewed":true,"short_name":"DUF4589","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/chemical-synaptic-transmission-postsynaptic-go0099565.yaml","source_record_id":"GO:0099565","source_record_label":"chemical synaptic transmission, postsynaptic","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8CD60","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15252","protein_label":"Inhibitory synaptic factor 1","reviewed":true,"short_name":"DUF4589","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/postsynaptic-specialization-organization-go0099084.yaml","source_record_id":"GO:0099084","source_record_label":"postsynaptic specialization organization","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q2T9L4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15252","protein_label":"Inhibitory synaptic factor 1","reviewed":true,"short_name":"DUF4589","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/postsynaptic-specialization-organization-go0099084.yaml","source_record_id":"GO:0099084","source_record_label":"postsynaptic specialization organization","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8CD60","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15252","protein_label":"Inhibitory synaptic factor 1","reviewed":true,"short_name":"DUF4589","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4589-pf15252.yaml","source_record_id":"Pfam:PF15252","source_record_label":"Domain of unknown function (DUF4589)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q2T9L4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15252","protein_label":"Protein Largen","reviewed":true,"short_name":"DUF4589","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4589-pf15252.yaml","source_record_id":"Pfam:PF15252","source_record_label":"Domain of unknown function (DUF4589)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q569H4","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15252","protein_label":"Inhibitory synaptic factor 1","reviewed":true,"short_name":"DUF4589","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4589-pf15252.yaml","source_record_id":"Pfam:PF15252","source_record_label":"Domain of unknown function (DUF4589)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"Q8CD60","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF15252","protein_label":"","reviewed":null,"short_name":"DUF4589","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4589-pf15252.yaml","source_record_id":"Pfam:PF15252","source_record_label":"Domain of unknown function (DUF4589)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":1173,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","description_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":3,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":3},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.","domain_architectures":5,"interpro_id":"IPR027997","known_evidence_count":null,"matches":1493,"name":"Domain of unknown function (DUF4589)","partial_evidence_count":null,"pfam_id":"PF15252","proteins":1353,"proteomes":679,"short_name":"DUF4589","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15252","structures":0,"taxa":2095,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15252.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":1173,"domain_architectures":5,"matches":1493,"proteins":1353,"proteomes":679,"structures":0,"taxa":2095},"curation_status":"SEEDED","description":"This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.","id":"Pfam:PF15252","interpro_id":"InterPro:IPR027997","name":"Domain of unknown function (DUF4589)","pfam_id":"PF15252","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4589","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15252"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15252.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"0d4e63ade688c2cc87673e98d058f8fb183a092b615043d7023837da0b6b150a"}},"protein_examples":{"candidate_count":3,"discovery_scanned":true,"example_count":3,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/postsynaptic-specialization-organization-go0099084.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0099084","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/postsynaptic-specialization-organization-go0099084.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4589-pf15252.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15252","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4589-pf15252.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q2T9L4","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF15252"],"protein_name":"Inhibitory synaptic factor 1","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"44516b7e4e0bf3e1c97f6a53bc41bdff933769e1cb96edb986dad7197ef35eb2","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MNIRGAPDLGQPSDDPSSGGERERIRQRMKMVIGQLEGILRELKEVAKELREVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGMGGPFDLGHLDFMTADILSDSWEFCSFLDVSTPSDSVDGPESTRPGAGPDYRLMNGGTPIPNGPRVETPDSSSEEAFGAGPTVKSQLPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEQEVEEEEVGLPPEPAHTEAHAGPHKPSPAPYKSRRSPLTSRHSGSTLAPEQTRRVTRNSSTQTVSDKSTQTVLPYTATRQKARGKN","sequence_length":293,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"44516b7e4e0bf3e1c97f6a53bc41bdff933769e1cb96edb986dad7197ef35eb2","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q2T9L4.json","taxon_id":"9606","uniprot_accession":"Q2T9L4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4589-pf15252.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15252","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4589-pf15252.yaml"}],"pfam_ids":["PF15252"],"protein_name":"Protein Largen","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSAKSKGNPSSSCPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSLEKIKVQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVKCEDPKRVVPTANPVKTNGTLLRNGGLPGGPNKIPNGDICCIPNSNLDKAPVQLLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYNIKNREVHLHSEPVHPPGKIPHQGPPLPPTPHLPPFPLENGGMGISHSNSFPPIRPATVPPPTAPKPQKTILRKSTTTTV","sequence_length":304,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"03d51b230e8f7eacfaa5b87c8e4c355bef107b2ec3f8b0fa27e38c6e4e9aa6c5","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q569H4.json","taxon_id":"9606","uniprot_accession":"Q569H4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/chemical-synaptic-transmission-postsynaptic-go0099565.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0099565","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/chemical-synaptic-transmission-postsynaptic-go0099565.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/postsynaptic-specialization-organization-go0099084.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0099084","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/postsynaptic-specialization-organization-go0099084.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4589-pf15252.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15252","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4589-pf15252.yaml"}],"pfam_ids":["PF15252"],"protein_name":"Inhibitory synaptic factor 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNIRGAPDLGQPSDDPNSGGERERIRQRMKMVIGQLEGILRELKEVAKELREVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGVGGPFDLGHLDFMTADILSDSWEFCSFLDVSTPSDSVDGPEAPRPGTGPDYQLMNGGLPIPNGPRVETPDSSSEEAFSAGPAKGQVPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEEGEEEEEGDLAPELPRVEPHTGPLKPSPAPYKTKRSPLTTRRLGPTLAPEQTRRVTRNSSTQTVSDKSTQTVLPYTATKQKAKGKN","sequence_length":292,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"830d64aea4b4db3a134cb608ae962a7880b5076ac2f2f29b89d6c0e24d5dd1ad","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8CD60.json","taxon_id":"10090","uniprot_accession":"Q8CD60","uniprot_release":"2026_03"}],"pfam_id":"PF15252","short_name":"DUF4589","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
