{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15257","protein_label":"Glutamate rich 3","reviewed":true,"short_name":"DUF4590","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4590-ipr048257.yaml","source_record_id":"InterPro:IPR048257","source_record_label":"Domain of unknown function DUF4590","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"F6QRE9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15257","protein_label":"Glutamate-rich protein 3","reviewed":true,"short_name":"DUF4590","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4590-ipr048257.yaml","source_record_id":"InterPro:IPR048257","source_record_label":"Domain of unknown function DUF4590","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q5RHP9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF15257","protein_label":"","reviewed":null,"short_name":"DUF4590","source_category":"sequence/domain/interpro","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4590-ipr048257.yaml","source_record_id":"InterPro:IPR048257","source_record_label":"Domain of unknown function DUF4590","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15257","protein_label":"Glutamate rich 3","reviewed":true,"short_name":"DUF4590","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4590-pf15257.yaml","source_record_id":"Pfam:PF15257","source_record_label":"Domain of unknown function (DUF4590)","source_section":"canonical_examples","taxon_id":"NCBITaxon:10090","taxon_label":"Mus musculus","uniprot_accession":"F6QRE9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15257","protein_label":"Glutamate-rich protein 3","reviewed":true,"short_name":"DUF4590","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4590-pf15257.yaml","source_record_id":"Pfam:PF15257","source_record_label":"Domain of unknown function (DUF4590)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q5RHP9","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF15257","protein_label":"","reviewed":null,"short_name":"DUF4590","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4590-pf15257.yaml","source_record_id":"Pfam:PF15257","source_record_label":"Domain of unknown function (DUF4590)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":753,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","description_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":2,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":2},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins remains to be characterised and is a domain of unknown function. This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: CCE and PCY. In humans, the gene encoding this protein lies in the position, chromosome 1 open reading frame 173.","domain_architectures":46,"interpro_id":"IPR048257","known_evidence_count":null,"matches":1354,"name":"Domain of unknown function (DUF4590)","partial_evidence_count":null,"pfam_id":"PF15257","proteins":1352,"proteomes":814,"short_name":"DUF4590","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15257","structures":0,"taxa":2665,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15257.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":753,"domain_architectures":46,"matches":1354,"proteins":1352,"proteomes":814,"structures":0,"taxa":2665},"curation_status":"SEEDED","description":"This family of proteins remains to be characterised and is a domain of unknown function. This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: CCE and PCY. In humans, the gene encoding this protein lies in the position, chromosome 1 open reading frame 173.","id":"Pfam:PF15257","interpro_id":"InterPro:IPR048257","name":"Domain of unknown function (DUF4590)","pfam_id":"PF15257","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4590","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15257"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15257.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"9d34b367406f7ab300bdd1f330714cb323b0f7b52ff7037d077827e5cf05fdee"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4590-ipr048257.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048257","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4590-ipr048257.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4590-pf15257.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15257","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4590-pf15257.yaml"}],"pfam_ids":["PF15257"],"protein_name":"Glutamate rich 3","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSHSHPAGLLATYNSLTDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKVNNMKQDHQKYIRECLARAIFHKVLDMERYHQLEIKRKLDTLARKERIQRLKGEHTRRFIEDNMPVLTPHPPAGPKTNRGHSVLAEEGRSSPLTLTAPRPYTAPGNMQPPVRLQPLLSSRQTRNGSKITSGSKPKGSLLESEALFPLGGKKAMMKFRNYMDHSQKEDLYQLPHINSYHTPVPPTPQPQAGKNFRDKRLESWRRKRLRPITAPNGLEPLFAKDPGRIYKTAPHSNAVITMVYFGKNVHLSYDDIDFRDEIKIYQQHCGGENLCVYKGKLLEKDTFQFISKRHHGFPFSLTFFLNGIQVNRISSCCEFKHRRSTRLGGKRGYFGFVCVEKASPCYRCIIAMGLDRKPSSTKPKKEKITEKKEEPPNKSQGKLRKDRMNAPSKRNEMERKESCVSAAFSAEEIKLGVKEVRTAIEEMEWKGKSGRDVWEEDQDNAVKYDYEEDFEVDDEKQDEKVDEDEDQADDQMSGGSKTPTESEKDNRNPEKKIETSSEKAHDSENEDTGCSDSEEDDRQDVKTMSSISSRSHPYSSESEDDSTEVGGEADSVSEEGSSRSSSSQDLRENDDPGKPHFPIEKYLETEIEEQEITEGHNGPWLTELSGMHVTEGKPTMGIQALSESEHKEPRRVASSEVRAKSQLQKEAGLPGVEEEVGQITGGAQEPGHCCSNTAPGLSPTDDGVTPMRKPEVNLGRGTEERAAISANEQPEQDAQEMHTLKEEAMKKDESSQPEDTDAHAGVREESGMQKDGTCHPQDAGIDVELRERVDMQEDGTCHPQGADMDVGLKERVGVQEDGTHYPQDADMDVGLRERVGMQEDGTHHSQDADMDVELKERVGMQEDGTCHPQDANMDVELKERVGMQEDGTCHPQDADMDVELEERTGMQEDGTHHPQGADVDLGLRERAGMQEDGTCYPQNANMDVGLREKAGISEVLLGERSPTGVLLASAEQSTEKGECYLNIASEAEAGTEGSSRHGEEQLIPTGKVAAEGSVFLSVEQARDRQKDEDLDRQALLQTQMEKERAVSEAGQELKAEFTDSGGLNSETLEEAAVLKEVGTSEVKEAEREVGSPKTDGDQGEEEALTELEVVGPVEDTGPERKAGSEETVLGGERAATERKDFLEEAPISASTGEVQASPREVFRGNHELCKEDTAREGVIADTESTAEQDLRAVFPGELAAAGGIEKVERLTPPLRETGSEREEETGPEVLKTEDLLGEQKVKGEEEGTAKEVGSEEEDRASRPEMEAHAKDVEPTGATELGEATKLLEDPPKERAITLSEATPQFGKSPKESEATATEHKGGEELPGQESKALWPQGRGLSHDGEGLLGAPGPEADKAQGPEGFFTARCEEWAAKELDSSAGSERLEEDQPLQAQREDIQRMTQGNLSGERLTRAVVVCGEAKAENPQGEGSEDKECPPGTVTGSLTGQNWNMGGNIVEAEEDPHGGGIEEPTAEQKEEESAESKSADGIPEASSAANAQKETWDGAGEALGEAAAEERTGTEDMAPRTEKVAVVEEVTSAGAMVETEQEQAPEAQDREGGETKASRHTGTAGEDTGSTGKDEEHQSGAAEEFRESVSQRETA","sequence_length":1637,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"9a198d94a5f0e5e1fcbd871e788883b3b2ffb9e4e43a7f025e5a255a24c91624","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/F6QRE9.json","taxon_id":"10090","uniprot_accession":"F6QRE9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4590-ipr048257.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR048257","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/domain-of-unknown-function-duf4590-ipr048257.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4590-pf15257.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15257","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4590-pf15257.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q5RHP9","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF15257"],"protein_name":"Glutamate-rich protein 3","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"87d545353c2b17a46ede33cdf250c64387bc71e3899d1f0d63e16c5274dd6aeb","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRDHQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPILSPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPKVTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPPTGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHLSSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVNRLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESETADVSPNNVQV","sequence_length":1530,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"87d545353c2b17a46ede33cdf250c64387bc71e3899d1f0d63e16c5274dd6aeb","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5RHP9.json","taxon_id":"9606","uniprot_accession":"Q5RHP9","uniprot_release":"2026_03"}],"pfam_id":"PF15257","short_name":"DUF4590","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
