{"cross_mech":[],"family":{"alphafold_models":349,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family (previously DUF4601) represents the homologues of Stabilizer of axonemal microtubules 5 (SAXO5, also known as C19orf45, TEX45). SAXO5 is a filamentous SAXO protein that binds along protofilament A04 with 96-nm periodicity [[cite:PUB00151496]]. A typical feature of SAXO proteins is the presence of Mn motif which forms a 5- to 6-residue helix flanked by a Tyr/Phe residue on one end and by a Ser/Thr on the other that binds the shoulder of the alpha-tubulin S9/S10 loop [[cite:PUB00151502]]. SAXO5 contains 11 Mn motifs and therefore has 96-nm periodicity, matching the external periodicity of the axoneme [[cite:PUB00151496]].","domain_architectures":9,"interpro_id":"IPR028001","known_evidence_count":null,"matches":447,"name":"Stabilizer of axonemal microtubules 5","partial_evidence_count":null,"pfam_id":"PF15373","proteins":425,"proteomes":338,"short_name":"SAXO5-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15373","structures":0,"taxa":1187,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15373.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":349,"domain_architectures":9,"matches":447,"proteins":425,"proteomes":338,"structures":0,"taxa":1187},"curation_status":"SEEDED","description":"This family (previously DUF4601) represents the homologues of Stabilizer of axonemal microtubules 5 (SAXO5, also known as C19orf45, TEX45). SAXO5 is a filamentous SAXO protein that binds along protofilament A04 with 96-nm periodicity [[cite:PUB00151496]]. A typical feature of SAXO proteins is the presence of Mn motif which forms a 5- to 6-residue helix flanked by a Tyr/Phe residue on one end and by a Ser/Thr on the other that binds the shoulder of the alpha-tubulin S9/S10 loop [[cite:PUB00151502]]. SAXO5 contains 11 Mn motifs and therefore has 96-nm periodicity, matching the external periodicity of the axoneme [[cite:PUB00151496]].","id":"Pfam:PF15373","interpro_id":"InterPro:IPR028001","name":"Stabilizer of axonemal microtubules 5","pfam_id":"PF15373","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"SAXO5-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15373"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15373.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"2d2c2373063d49090e66e387a788b3e6b4006a05dd82e6e2f0ead5ae0a15e6ef"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/saxo5-like-pf15373.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15373","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/saxo5-like-pf15373.yaml"}],"pfam_ids":["PF15373"],"protein_name":"Stabilizer of axonemal microtubules 5","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MATGALLPCSRPCPMSRLDFLKASHFSLGPDLRLHEGTMRTTSHRDFAYPAATREPPSLQPPPALLFPMDPRWDREERVSEAHRAFPPPSTPPWELLQAQARERTLAMQAGNLHLHEDAHAGIGLSNAHAAYGWPELPARTRERIRGARLIFDRDSLPPGDRDKLRIPPTTHQALFPPHDARPQPRAPSCHLGGPNTLKWDYTRQDGTSYQRQFQALPGPPALRCKRASSGVELGDCKISYGSTCSEQKQAYRPQDLPEDRYDKAQATAHIHCVNIRPGDGLFRDRTTKAEHFYAREPEPFVLHHDQTPESHILKGNWCPGPGSLDTFMQYFYGQPPPPTQPPSRHVPHEKLQSHVTLGEPKLLKRFFKTTMGSDYCPSEWRQVQKAPNLHLQQSYLPRGTGEFDFLTMNQKMLKPHRTPPAPVTEEMLQRCKYSHMEPPLGGLRFFSTQYKDEFPFKYQGPAALRLKNPQEGFVPLGTPHQRGCREKIDPLVPQPPMYLCPSQQ","sequence_length":505,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"d35a79e5649f674b938c8eda227c78027b76a47f557e48d5531986d28448840a","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q8NA69.json","taxon_id":"9606","uniprot_accession":"Q8NA69","uniprot_release":"2026_03"}],"pfam_id":"PF15373","short_name":"SAXO5-like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}