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The specific function of this C-terminal region remains to be determined.","domain_architectures":8,"interpro_id":"IPR027866","known_evidence_count":null,"matches":514,"name":"Retroelement silencing factor 1 C-terminal region","partial_evidence_count":null,"pfam_id":"PF15395","proteins":453,"proteomes":284,"short_name":"RESF1_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15395","structures":0,"taxa":954,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15395.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":20,"domain_architectures":8,"matches":514,"proteins":453,"proteomes":284,"structures":0,"taxa":954},"curation_status":"SEEDED","description":"This entry represents the C-terminal region of approximately 1000 residues found in retroelement silencing factor 1 (RESF1) proteins in vertebrates. The full-length RESF1 protein interacts with the histone methyltransferase SETDB1 and is required for the recruitment of SETDB1 to endogenous retroviruses (ERVs), contributing to ERV silencing in embryonic stem cells [[cite:PUB00092441]]. The specific function of this C-terminal region remains to be determined.","id":"Pfam:PF15395","interpro_id":"InterPro:IPR027866","name":"Retroelement silencing factor 1 C-terminal 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