{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15548","protein_label":"Septin-4","reviewed":true,"short_name":"DUF4655","source_category":"function/localization/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/localization/go/sperm-annulus-go0097227.yaml","source_record_id":"GO:0097227","source_record_label":"sperm annulus","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"O43236","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15548","protein_label":"Septin-4","reviewed":true,"short_name":"DUF4655","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/hematopoietic-stem-cell-homeostasis-go0061484.yaml","source_record_id":"GO:0061484","source_record_label":"hematopoietic stem cell homeostasis","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"O43236","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15548","protein_label":"Septin-4","reviewed":true,"short_name":"DUF4655","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/spermatid-differentiation-go0048515.yaml","source_record_id":"GO:0048515","source_record_label":"spermatid differentiation","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"O43236","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15548","protein_label":"Septin-4","reviewed":true,"short_name":"DUF4655","source_category":"sequence/disorder/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/disorder/pfam/duf4655-pf15548.yaml","source_record_id":"Pfam:PF15548","source_record_label":"Domain of unknown function (DUF4655)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"O43236","unknown_status":"UNKNOWN_CANDIDATE"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF15548","protein_label":"","reviewed":null,"short_name":"DUF4655","source_category":"sequence/disorder/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/disorder/pfam/duf4655-pf15548.yaml","source_record_id":"Pfam:PF15548","source_record_label":"Domain of unknown function (DUF4655)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"UNKNOWN_CANDIDATE"}],"family":{"alphafold_models":116,"candidate_reasons":["short_name_matches_duf","name_says_unknown_function","domain_of_unknown_function"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":1,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":4},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins is found in eukaryotes. Proteins in this family are typically between 533 and 570 amino acids in length.","domain_architectures":7,"interpro_id":"IPR027979","known_evidence_count":null,"matches":166,"name":"Domain of unknown function (DUF4655)","partial_evidence_count":null,"pfam_id":"PF15548","proteins":156,"proteomes":122,"short_name":"DUF4655","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15548","structures":0,"taxa":420,"unknown_status":"UNKNOWN_CANDIDATE"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15548.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":116,"domain_architectures":7,"matches":166,"proteins":156,"proteomes":122,"structures":0,"taxa":420},"curation_status":"SEEDED","description":"This family of proteins is found in eukaryotes. Proteins in this family are typically between 533 and 570 amino acids in length.","id":"Pfam:PF15548","interpro_id":"InterPro:IPR027979","name":"Domain of unknown function (DUF4655)","pfam_id":"PF15548","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"UNKNOWN_CANDIDATE","short_name":"DUF4655","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15548"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15548.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"73a3747220c7a1553baa0613497b2e183f48c5c9f51c070a242a02a3e00321fd"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/localization/go/sperm-annulus-go0097227.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0097227","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/localization/go/sperm-annulus-go0097227.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/hematopoietic-stem-cell-homeostasis-go0061484.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0061484","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/hematopoietic-stem-cell-homeostasis-go0061484.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/spermatid-differentiation-go0048515.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0048515","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/spermatid-differentiation-go0048515.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/disorder/pfam/duf4655-pf15548.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15548","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/disorder/pfam/duf4655-pf15548.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:O43236","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF00735","PF15548"],"protein_name":"Septin-4","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"f29ad71f36d67f776f5834aafea4941eb019e474dc70f577f7f83d533cee825d","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MVKTNKPGAKVAVSAQRGSEVTTNTSPQQGHGYVLASSHRSAAVSLNPSHRRSEAAHPTTPHSASDYPRSVSLQSGPGHYAVPTPRGPETGPRTESSRHSSPHLKSQKTQTLASHASSRQWKVSPPREEAARRGSESKSGREVGHHASSIPDAKSTHQLSFQDQKNNLQSQILEDDPPSKVQNPQGVRVPRRILSYPKDEAVQTEPIQRITTTSEIRSPRSPSLLEHGSSCVSADYQTAQRRVPVEESETGPYGPIPSKPKALYRNMNLDSLLKLSVLKDSDGVHRVSARVDPESLHKYSAYPETKPSAKVLVSSQVESNVRTPIRGNSEVGRRVTISPGVQSVEPTHHVTVPSVSEGSHKSSMFVTPEPIYKQQTQKPPEITYMSQGPTPRYPELSQKPSIHAELELTPRPLPPRSLPRYGPDSSWWPLLNPEVETPQSQLTTPDFEPKCSPSLDLLLSGFKIDSSPFCEDLKFQREKASLSPPSPPKEFPSWAPLSEVPQTPKHTCKQPIQRFTAFFLDVSEEMYNRVIWWLKDEEIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQVPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQKQMKENY","sequence_length":996,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"f29ad71f36d67f776f5834aafea4941eb019e474dc70f577f7f83d533cee825d","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/O43236.json","taxon_id":"9606","uniprot_accession":"O43236","uniprot_release":"2026_03"}],"pfam_id":"PF15548","short_name":"DUF4655","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
