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Knockout of Brme1 results in male mice infertility [[cite:PUB00095580]].","domain_architectures":4,"interpro_id":"IPR031441","known_evidence_count":null,"matches":519,"name":"Break repair meiotic recombinase recruitment factor 1","partial_evidence_count":null,"pfam_id":"PF15710","proteins":393,"proteomes":232,"short_name":"Brme1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15710","structures":2,"taxa":865,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15710.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":330,"domain_architectures":4,"matches":519,"proteins":393,"proteomes":232,"structures":2,"taxa":865},"curation_status":"SEEDED","description":"Brme1 (also known as Meiok21) is a component of meiotic recombination bridges involved in meiotic double-strand break repair [[cite:PUB00095580],[cite:PUB00095581]]. The C-terminal domain of Brme1 physically interacts with the N-terminal domain of HSF2BP [[cite:PUB00095580]]. BRME1 facilitates the loading of RAD51 and DMC1 recombinases onto DSBs (DNA double-strand breaks) through interaction with MEILB2/HSF2BP and replacing ssDNA binding proteins [[cite:PUB00095581]]. Brme1 is highly expressed in mice testes and fetal ovaries. Knockout of Brme1 results in male mice infertility [[cite:PUB00095580]].","id":"Pfam:PF15710","interpro_id":"InterPro:IPR031441","name":"Break repair meiotic recombinase recruitment factor 1","pfam_id":"PF15710","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Brme1","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15710"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15710.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"41865e9c8eff4b425c5839ec26bce45e415b9572a2a075970fce81537853dee7"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/disorder/pfam/brme1-pf15710.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15710","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/disorder/pfam/brme1-pf15710.yaml"}],"pfam_ids":["PF15710"],"protein_name":"Break repair meiotic recombinase recruitment factor 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MTKRKKLRTSGEGLCPPKPLKNPRLGDFYGDPQSSMLGCLHHPEEPEGKLGPVPSTQQHGEEPGKAVSSSPDEETGSPCRLLRQPEKEPAPLPPSQNSFGRFVPQFAKSRKTVTRKEEMKDEDRGSGAFSLETIAESSAQSPGCQLLVETLGVPLQEATELGDPTQADSARPEQSSQSPVQAVPGSGDSQPDDPPDRGTGLSASQRASQDHLSEQGADDSKPETDRVPGDGGQKEHLPSIDSEGEKPDRGAPQEGGAQRTAGAGLPGGPQEEGDGVPCTPASAPTSGPAPGLGPASWCLEPGSVAQGSPDPQQTPSRMGREGEGTHSSLGCSSLGMVVIADLSTDPTELEERALEVAGPDGQASAISPASPRRKAADGGHRRALPGCTSLTGETTGESGEAGQDGKPPGDVLVGPTASLALAPGSGESMMGAGDSGHASPDTGPCVNQKQEPGPAQEEAELGGQNLERDLEGFRVSPQASVVLEHREIADDPLQEPGAQQGIPDTTSELAGQRDHLPHSADQGTWADSLAVELDFLLDSQIQDALDASDFEAPPEQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAFKRLNYRKTKLGGKAPLPYPSKGPGNIPRGDPPWREL","sequence_length":668,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"02df8b3bb9e44b33c56a24b5f19c081499a9635d77dc8b5ab55e9b623687fe52","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q0VDD7.json","taxon_id":"9606","uniprot_accession":"Q0VDD7","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/disorder/pfam/brme1-pf15710.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15710","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/disorder/pfam/brme1-pf15710.yaml"}],"pfam_ids":["PF15710"],"protein_name":"Break repair meiotic recombinase recruitment factor 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MNKKKQRNSGVGLHPSKPSKNPRLRDSQSSMMVHSHYSRESEDSSEPAPSVELGGEEPLHEAFSCPVEDTGAASDLAGSPKELVPLPPSQNSVGKFVPQFAKPRKTVTRKAKAWEEDLEGCTTSQETRPELGALKAASQPQRESLRFPPHDIRPEVQTQPDGTLSKERTISLDNRSLGNNGFEMATVQDSSSPLSDAAAEGREADSRDPQERDAQGGEAGAQHSGEPQEGEDILYTSALAPASEPTWSVAQDLSVPTYTLSSTAAAPSSTSPADASLMDTVITEVSLDPSVLQQSAPQVAKLLGSLDEQIPDGGCIGTLLSSTPLAEETTAGREEARWEERCHGDTLASFTETEPEKQEPVTEAGDSGHIAQEMDPVVKTKDSGSDEQSPGDIGMLPLPAQSMNQMLVELRGLTCDQDLEGLSTPHTSSQLEHTCAASDPPQSTKDCHSSPGIPVHLAAPCPRDQAAWQESSAMELDFLPDSQIQDALDATNMEQGFPSGSMPDLGWPVPSSQSIGGSPKAVTKPQSRSHVETWAQETYRMQDATDTVRGLVVELSGLNRLIMSTHRDLEAFKRRKTKSLPYLTKGLGSLPRGDQSWRDL","sequence_length":600,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"26b7babd534c9f6599c185c64f84ba9a60bbf996f42c1676888e22032572f85b","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q6DIA7.json","taxon_id":"10090","uniprot_accession":"Q6DIA7","uniprot_release":"2026_03"}],"pfam_id":"PF15710","short_name":"Brme1","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}