{"cross_mech":[{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15763","protein_label":"Regulator of hemoglobinization and erythroid cell expansion protein","reviewed":true,"short_name":"DUF4692","source_category":"function/molecular_function/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/molecular_function/go/erythropoietin-receptor-binding-go0005128.yaml","source_record_id":"GO:0005128","source_record_label":"erythropoietin receptor binding","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q6ZWK4","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":false,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15763","protein_label":"Regulator of hemoglobinization and erythroid cell expansion protein","reviewed":true,"short_name":"DUF4692","source_category":"function/pathway/go","source_mech":"ProteinTraitsMech","source_path":"data/traits/function/pathway/go/cellular-response-to-erythropoietin-go0036018.yaml","source_record_id":"GO:0036018","source_record_label":"cellular response to erythropoietin","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q6ZWK4","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":true,"link_basis":["canonical_example_family_classification"],"pfam_id":"PF15763","protein_label":"Regulator of hemoglobinization and erythroid cell expansion protein","reviewed":true,"short_name":"DUF4692","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4692-pf15763.yaml","source_record_id":"Pfam:PF15763","source_record_label":"Regulator of human erythroid cell expansion (RHEX)","source_section":"canonical_examples","taxon_id":"NCBITaxon:9606","taxon_label":"Homo sapiens","uniprot_accession":"Q6ZWK4","unknown_status":"KNOWN_HISTORICAL_DUF"},{"cited_uniprot_accession":"","family_mentioned_in_record":null,"link_basis":["trait_identifier"],"pfam_id":"PF15763","protein_label":"","reviewed":null,"short_name":"DUF4692","source_category":"sequence/family/pfam","source_mech":"ProteinTraitsMech","source_path":"data/traits/sequence/family/pfam/duf4692-pf15763.yaml","source_record_id":"Pfam:PF15763","source_record_label":"Regulator of human erythroid cell expansion (RHEX)","source_section":"trait_identifier","taxon_id":"","taxon_label":"","uniprot_accession":"","unknown_status":"KNOWN_HISTORICAL_DUF"}],"family":{"alphafold_models":220,"candidate_reasons":["short_name_matches_duf"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":1,"protein_traits_record":true,"records_by_mech":{"ProteinTraitsMech":3},"scanned":true},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family of proteins is found in eukaryotes. Family members include human RHEX proteins which regulates erythroid progenitor cell expansion and erythroblast development [[cite:PUB00088308]].","domain_architectures":2,"interpro_id":"IPR031517","known_evidence_count":null,"matches":297,"name":"Regulator of human erythroid cell expansion (RHEX)","partial_evidence_count":null,"pfam_id":"PF15763","proteins":257,"proteomes":178,"short_name":"DUF4692","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15763","structures":0,"taxa":615,"unknown_status":"KNOWN_HISTORICAL_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15763.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":220,"domain_architectures":2,"matches":297,"proteins":257,"proteomes":178,"structures":0,"taxa":615},"curation_status":"SEEDED","description":"This family of proteins is found in eukaryotes. Family members include human RHEX proteins which regulates erythroid progenitor cell expansion and erythroblast development [[cite:PUB00088308]].","id":"Pfam:PF15763","interpro_id":"InterPro:IPR031517","name":"Regulator of human erythroid cell expansion (RHEX)","pfam_id":"PF15763","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"KNOWN_HISTORICAL_DUF","short_name":"DUF4692","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15763"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF15763.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"4eb57a02521b045f20cbbb3590dea9797f96394513bfa2c35ba9909534eac85a"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/erythropoietin-receptor-binding-go0005128.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0005128","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/erythropoietin-receptor-binding-go0005128.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/cellular-response-to-erythropoietin-go0036018.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0036018","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/cellular-response-to-erythropoietin-go0036018.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf4692-pf15763.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF15763","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf4692-pf15763.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q6ZWK4","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF15763"],"protein_name":"Regulator of hemoglobinization and erythroid cell expansion protein","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"db6ea04a47120a37ac74a1c65d8ac69629ee7331b9ca2ac3622e46c03e594fad","sequence_version":1,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MLTEVMEVWHGLVIAVVSLFLQACFLTAINYLLSRHMAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKETQTERDIPMSDSLYRHDSDTPSDSLDSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPAEYDQVAM","sequence_length":172,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"db6ea04a47120a37ac74a1c65d8ac69629ee7331b9ca2ac3622e46c03e594fad","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q6ZWK4.json","taxon_id":"9606","uniprot_accession":"Q6ZWK4","uniprot_release":"2026_03"}],"pfam_id":"PF15763","short_name":"DUF4692","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}