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This 9kDa CC-motif containing cationic polypeptide has been previously described as the 57 amino acid antimicrobial peptide AP-57, and as a Sushi Containing Domain-2 (SUSD2)-binding factor (CSBF), capable of inhibiting the growth of intestinal epithelial cancer cell lines. The chemokine is expressed by epithelial cells in gastrointestinal and genitourinary mucosae and in the skin [[cite:PUB00088054]]. In humans GPR15L, is encoded by the gene C10ORF99 and has some features similar to the CC family of chemokines [[cite:PUB00088053]]. However, it lacks significant homology to classic CC and CXC chemokines, yet shares many features with them, including a cationic domain predicted to comprise two disulfide bonds and a highly conserved GPCR-activating terminal peptide. Furthermore, the activating peptides of CC chemokines are typically located at the N-terminus, while that of GPR15L is C-terminal, a feature that it shares with some other GPCR ligands like chemerin and apela [[cite:PUB00088054]].","domain_architectures":4,"interpro_id":"IPR031713","known_evidence_count":null,"matches":122,"name":"G-protein coupled receptor ligand 15","partial_evidence_count":null,"pfam_id":"PF15854","proteins":121,"proteomes":114,"short_name":"GPR15L","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15854","structures":1,"taxa":422,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF15854.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":106,"domain_architectures":4,"matches":122,"proteins":121,"proteomes":114,"structures":1,"taxa":422},"curation_status":"SEEDED","description":"GPR15 is an orphan G protein-coupled receptor (GPCR) that is found in lymphocytes. It functions as a co-receptor of simian immunodeficiency virus and HIV-2 and plays a role in the trafficking of T cells to the lamina propria in the colon and to the skin [[cite:PUB00088053]]. An activating ligand named GPR15L is shown to bind GPR15 and attract GPR15-expressing T cells including lymphocytes in colon-draining lymph nodes and thymic precursors of dermal epithelial T cell. This 9kDa CC-motif containing cationic polypeptide has been previously described as the 57 amino acid antimicrobial peptide AP-57, and as a Sushi Containing Domain-2 (SUSD2)-binding factor (CSBF), capable of inhibiting the growth of intestinal epithelial cancer cell lines. The chemokine is expressed by epithelial cells in gastrointestinal and genitourinary mucosae and in the skin [[cite:PUB00088054]]. In humans GPR15L, is encoded by the gene C10ORF99 and has some features similar to the CC family of chemokines [[cite:PUB00088053]]. However, it lacks significant homology to classic CC and CXC chemokines, yet shares many features with them, including a cationic domain predicted to comprise two disulfide bonds and a highly conserved GPCR-activating terminal peptide. Furthermore, the activating peptides of CC chemokines are typically located at the N-terminus, while that of GPR15L is C-terminal, a feature that it shares with some other GPCR ligands like chemerin and apela [[cite:PUB00088054]].","id":"Pfam:PF15854","interpro_id":"InterPro:IPR031713","name":"G-protein coupled receptor ligand 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