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Yeast Suicide Protein 2 (YSP2), a mitochondrial membrane protein involved in mitochondrial fragmentation and may be involved in sterol transfer between intracellular membranes.It is also found in human GramD1a-c.","domain_architectures":194,"interpro_id":"IPR031968","known_evidence_count":null,"matches":14430,"name":"VAD1 Analog of StAR-related lipid transfer domain","partial_evidence_count":null,"pfam_id":"PF16016","proteins":12938,"proteomes":3299,"short_name":"VASt","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16016","structures":12,"taxa":8680,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF16016.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":9903,"domain_architectures":194,"matches":14430,"proteins":12938,"proteomes":3299,"structures":12,"taxa":8680},"curation_status":"SEEDED","description":"The VASt (VAD1 Analog of StAR-related lipid transfer) domain is conserved across eukaryotes and is structurally related to Bet v1-like domains, including START lipid-binding domains. 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Yeast Suicide Protein 1 (YSP1), a mitochondrial protein specifically required for the mitochondrial thread-grain transition, de-energization, and the cell death. May be involved in sterol transfer between intracellular membranes. Yeast Suicide Protein 2 (YSP2), a mitochondrial membrane protein involved in mitochondrial fragmentation and may be involved in sterol transfer between intracellular membranes.It is also found in human GramD1a-c.","id":"Pfam:PF16016","interpro_id":"InterPro:IPR031968","name":"VAD1 Analog of StAR-related lipid transfer 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