{"cross_mech":[],"family":{"alphafold_models":470,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a class of MavL-like macrodomain enzymes whose representative members show unique selectivity for mono-ADP-ribosylated arginine residue in synthetic substrates, including [swissprot:Q9W2W5] and [swissprot:Q9W4J9] from Drosophila melanogaster, which are distantly related to MavL from Legionella pneumophila [[cite:PUB00155313]]. They are (ADP-ribosyl)hydrolases that share a mode of ADP-ribose interaction distinct from previously characterised macrodomains [[cite:PUB00155313]].","domain_architectures":24,"interpro_id":"IPR032063","known_evidence_count":null,"matches":750,"name":"ADP-ribosylhydrolase MavL-like","partial_evidence_count":null,"pfam_id":"PF16062","proteins":581,"proteomes":319,"short_name":"MavL-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16062","structures":2,"taxa":1126,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF16062.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":470,"domain_architectures":24,"matches":750,"proteins":581,"proteomes":319,"structures":2,"taxa":1126},"curation_status":"SEEDED","description":"This entry represents a class of MavL-like macrodomain enzymes whose representative members show unique selectivity for mono-ADP-ribosylated arginine residue in synthetic substrates, including [swissprot:Q9W2W5] and [swissprot:Q9W4J9] from Drosophila melanogaster, which are distantly related to MavL from Legionella pneumophila [[cite:PUB00155313]]. They are (ADP-ribosyl)hydrolases that share a mode of ADP-ribose interaction distinct from previously characterised macrodomains [[cite:PUB00155313]].","id":"Pfam:PF16062","interpro_id":"InterPro:IPR032063","name":"ADP-ribosylhydrolase MavL-like","pfam_id":"PF16062","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"MavL-like","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16062"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF16062.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"bb7e59414ecc413ca33cf868735db9b585365381581aa7ed6d550bb623be7e10"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/adp-ribosylarginine-protein-hydrolase-activity-go0003875.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0003875","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/adp-ribosylarginine-protein-hydrolase-activity-go0003875.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/mavl-like-pf16062.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16062","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/mavl-like-pf16062.yaml"}],"pfam_ids":["PF16062"],"protein_name":"ADP-ribosylarginine hydrolase CG2909","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSTFGAEVDQVWPAVTGDSPHLTNFGRKLLKDCRQVQKPIGGYENLGNVIKLSAEFPLEFGVNSVKVYRQSPSRLARINEEVASAYPLIHERTLGLYLQYLEHKCRWGNAVEKPIYRNLSLCGFVQRLLVKRCASFFARNDKYLLVSGESGASGFEAVGTREEKAPLVLANVLSYDDIKLSALLSVSSRTEFVNEGERTNCGHVDLNTKTLERHGVIVGMIGARLSRRNLMEFQDIVIARQQNTRERGYGMALDEPATTRDEDYRRLWREFYATRDLIHGQAVIDNQRFGPSKNKMDVFDNLVMKRRYAISFDMLLLEAEARAKRVKKLAYIHVVGFGLGVWKAAEQQERIFMETFEQRMRTLGNRLNNVGLVHFSWFSITHCGGLSNGSLIEIPGHPKDGIRVLISKRNPARKLSDPEHAGMLLVVSYAWDGNALPGNEFWMKMLQSTGDSSTACSTLVAELHNPYINTKFCNGGNLHIASPEHGVLHIAEYAKRVIRSESDAL","sequence_length":505,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6d00535c3ebbeff04d3af934c13233820562fce90c7ddf3c72a7af047ff7f6fb","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q9W2W5.json","taxon_id":"7227","uniprot_accession":"Q9W2W5","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Drosophila melanogaster","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/molecular_function/go/adp-ribosylarginine-protein-hydrolase-activity-go0003875.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0003875","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/molecular_function/go/adp-ribosylarginine-protein-hydrolase-activity-go0003875.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/mavl-like-pf16062.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16062","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/mavl-like-pf16062.yaml"}],"pfam_ids":["PF16062"],"protein_name":"ADP-ribosylarginine hydrolase CG3568","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MRSFLYMLSQRPKLACLCGKSIIIWPGKRTNLPENAFTQRMLQECGQMAKPDASVDLDNFKAISEQSPAEFGIDSCRVKAQPEDRSDRIREQIASAYPVIHERTLLLFISFLEHKLTFGSEQEKAIYKDMTVVDLVQRLLAKRCVWFFGANDYYRTMQGNIGNEGFEAVGTPAEKEPLTLTSVLSYDEIKLSALLYVSCHSEFINNGSRVNGGEVLQNKDTIEREGVVIGLIGARFERPDVMEYQDIMITKTQNTEANGYGFDLEQISSETVTPASDLRRIWREFYEEPRDFIYADTPYDTTRFEEVSQGIFDHQVMRKRYAISFDTLLLEAQDRAFKAGKPAYIHVVGIGLGVWKAARQQERTFLESFEGRLRALGERLSHIGVVHFSWFHLACVGSLHDGAIIPVDKHPQGGIRIRNSVRNPGDKLTEDMLPVVTYAWDGNALPGNEFWANMLISTGDPAAACSTLISELQNPHINVHYMNGANLHIASVEHGLLHVGDYARRLIV","sequence_length":508,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"e96e1998af231b58f41730af94d3c8781aa5e01347bc51d11e0d87abf78c384f","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q9W4J9.json","taxon_id":"7227","uniprot_accession":"Q9W4J9","uniprot_release":"2026_03"}],"pfam_id":"PF16062","short_name":"MavL-like","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
