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This domain is predicted to adopt a mainly beta-configuration.","domain_architectures":28,"interpro_id":"IPR032147","known_evidence_count":null,"matches":1549,"name":"Protein capicua homolog-like domain","partial_evidence_count":null,"pfam_id":"PF16090","proteins":1545,"proteomes":802,"short_name":"Cic","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16090","structures":0,"taxa":2815,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF16090.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":277,"domain_architectures":28,"matches":1549,"proteins":1545,"proteomes":802,"structures":0,"taxa":2815},"curation_status":"SEEDED","description":"This domain is found in protein capicua homolog (Cic) and similar animal proteins. Cic is a transcriptional repressor which plays a role in the development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, it is involved in brain development [[cite:PUB00148730],[cite:PUB00053281],[cite:PUB00148732]]. This domain is predicted to adopt a mainly beta-configuration.","id":"Pfam:PF16090","interpro_id":"InterPro:IPR032147","name":"Protein capicua homolog-like domain","pfam_id":"PF16090","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Cic","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16090"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF16090.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"39851500740ada506c886ae017cbd99fdb0c2f5aa88cf840f94d888b1ef241da"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus 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