{"cross_mech":[],"family":{"alphafold_models":4801,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents a domain found in eukaryotic Gag or capsid-like retrotranspon-related proteins, including LDOC1, and RTL1/3-8 from animals. LDOC1 is a MZF-1-interacting protein, inhibits NF-kappaB activation and relates with cancer and some other diseases [[cite:PUB00070719],[cite:PUB00076517],[cite:PUB00076518],[cite:PUB00076519]]. LDOC1 is a small protein and this entry covers almost its full length. In RTL proteins, it represents the N-terminal capsid-like domain. RTL1 plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta [[cite:PUB00091629]]. RTL3 plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal [[cite:PUB00163386]].","domain_architectures":405,"interpro_id":"IPR032549","known_evidence_count":null,"matches":7573,"name":"RTL1/3-8/LDOC, capsid-like domain","partial_evidence_count":null,"pfam_id":"PF16297","proteins":7561,"proteomes":514,"short_name":"RTL1-8_LDOC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16297","structures":0,"taxa":1766,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF16297.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":4801,"domain_architectures":405,"matches":7573,"proteins":7561,"proteomes":514,"structures":0,"taxa":1766},"curation_status":"SEEDED","description":"This entry represents a domain found in eukaryotic Gag or capsid-like retrotranspon-related proteins, including LDOC1, and RTL1/3-8 from animals. LDOC1 is a MZF-1-interacting protein, inhibits NF-kappaB activation and relates with cancer and some other diseases [[cite:PUB00070719],[cite:PUB00076517],[cite:PUB00076518],[cite:PUB00076519]]. LDOC1 is a small protein and this entry covers almost its full length. In RTL proteins, it represents the N-terminal capsid-like domain. RTL1 plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta [[cite:PUB00091629]]. RTL3 plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal [[cite:PUB00163386]].","id":"Pfam:PF16297","interpro_id":"InterPro:IPR032549","name":"RTL1/3-8/LDOC, capsid-like domain","pfam_id":"PF16297","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"RTL1-8_LDOC","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16297"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF16297.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"0bb104abb4588674b0bb74f3fc68b27291cacfbd52748d4e1d611eca7c9f9190"}},"protein_examples":{"candidate_count":11,"discovery_scanned":true,"example_count":11,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/retropepsins-pepsin-like-aspartate-proteases-the-family-includes-pepsi-cd00303.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd00303","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/retropepsins-pepsin-like-aspartate-proteases-the-family-includes-pepsi-cd00303.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/rt-ltr-reverse-transcriptases-rts-from-retrotransposons-and-retrovirus-cd01647.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd01647","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/rt-ltr-reverse-transcriptases-rts-from-retrotransposons-and-retrovirus-cd01647.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/reverse-transcriptase-retrotransposon-derived-protein-rnase-h-like-dom-ipr041577.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR041577","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/reverse-transcriptase-retrotransposon-derived-protein-rnase-h-like-dom-ipr041577.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rt-rnaseh-2-pf17919.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF17919","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rt-rnaseh-2-pf17919.yaml"}],"pfam_ids":["PF16297","PF17919","PF30863","PF30901"],"protein_name":"Retrotransposon-like protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MIEPSEDSFETMMEHKNPSSKQMESSEGSSNTTEATSGSGVRGEAGPASGPAQEKKEPPSGPLQEMEELPTDLLQDMEEPSSGPRKEIEDPPNDLLQDLEESCNGSHQARGDPLSGASDRMKEASVNPSGAREEQEAHTDLKESGREETPQEQNQTEHSTAELMAMVRSIISLYFRMQDLKEQQRVAEEILIKGINAGQLPAPKHFSGDRREFHEFIVLCQLTLQSYPRMFYNDRLRVGYVINHLSGLALEWAKALLQENSPLIGDFPAFLEAMSEVFEYRQALRVAEEAMFTIRQGGRSATEYIDEFQSLVPILGWPDEVLQAHLCQGLNEEIRHYLFRVPQPDSLDSLIVLILQIEEKLAERRAMLRLPPEARPRNLTWIDSPAPERWMVSSWLPSEVHPDINRAHLFLLLMVRVNPYHSVAVQALVDSGADGNFMDEKFAQEHYVELYEKPYPQPVQSVDGSLIGNEPVWLYTEPLVCIHQNHQESIEFDIVPSPNFSVVLGIRWLRVHAPEVDWIKGRCTFHSPYCLKNCFRPPPPCIALERHGMSLLPGLPHPYSDLADVFNPKEADDETSDQPSSDGSDDLSESEPSELQQAGDSDHSETFYECPSTAPWEPVGARMQERARLQEEYWDLQDMLTNRQDYIQMIPELFDQLHGAEWFTKLELRGTIVEESVNGHRTEDVWKAAFGLELEEMKSYQPFALSPDPIIPQNVIHFILKDMLGFFVLSYGQEVLIYSMSQEEHLHHVRQVLVRFRHHNVYCSLDKSQFHRQTVEFLGFVVTPKGVKLNKNVMTIITGYPTPGSKLSLRNFIEFVFPYRHFVERFSIIAEPLVRQLLSSYQFYWGVEEQEAFECLKRAFRKAPLLHHPKPQNPFYLETGVTGTALHASLIQIDDQTGKRACCAFYSRNISPIEVEYSQAEMKILPIRAAFMVWCRYLENTEEPIMILLNTEDLASLNNDRLTVLLPGHWVFFFSHFNFDVMELPEQDGGRALPPVRNLRWRRAFQRNTAARQTLLLASRGFPRDPSTESGEEENEEQDELNEQILRQELLAMIPIDQILNSFLAHFSMAQIRAVILHFFRGLLYWKNTLALAAILVLLRVRQCLSLRPAPAMRVARPQPQRSLRLILDSSLIAGSSITTAITQLLTQMPALVGANTIPAQELAELFLGPGRWQRNALHSQAHRGLQFTPGFWLTLCEFFGVRVTPQEGHLPALRQNRYLELHVVGDEDVVLREALQDDLQRYRQCGLHDGLQDTSQDKQDNDVQEAPPSHTAATHPPRPRHLMDPQVLEFLGSRLLHIHSADGQLHLLSREQAARALSQFLTLIYRRALPIPAWESQPREQARLEELPDEDEDANLD","sequence_length":1358,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"685cbde74c66462c1efbd896c72f9392855d0a26fec206c3f1933fe3198df53f","sequence_version":3,"source_url":"https://rest.uniprot.org/uniprotkb/A6NKG5.json","taxon_id":"9606","uniprot_accession":"A6NKG5","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16297","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml"}],"pfam_ids":["PF16297"],"protein_name":"Retrotransposon Gag-like protein 8C","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MDGRVQLIKALLALPIRPATRRWRNPIPFPETFDGDTDRLPEFIVQTGSYMFVDENTFSSDALKVTFLITRLTGPALQWVIPYIKKESPLLNDYRGFLAEMKRVFGWEEDEDF","sequence_length":113,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"7a2078bb0326f9401c1fa0f38c66b825d0e8e80f8e7af1500b22654320b83b01","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/A6ZKI3.json","taxon_id":"9606","uniprot_accession":"A6ZKI3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16297","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml"}],"pfam_ids":["PF16297"],"protein_name":"Protein LDOC1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVDELVLLLHALLMRHRALSIENSQLMEQLRLLVCERASLLRQVRPPSCPVPFPETFNGESSRLPEFIVQTASYMLVNENRFCNDAMKVAFLISLLTGEAEEWVVPYIEMDSPILGDYRAFLDEMKQCFGWDDDEDDDDEEEEDDY","sequence_length":146,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"6477d4308db581159fa0b4be93ff0b1ba06fff9b4f9a04acad112c2f11096b95","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/O95751.json","taxon_id":"9606","uniprot_accession":"O95751","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16297","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml"}],"pfam_ids":["PF16297"],"protein_name":"Retrotransposon Gag-like protein 8B","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MEGRVQLMKALLARPLRPAARRWRNPIPFPETFDGDTDRLPEFIVQTSSYMFVDENTFSNDALKVTFLITRLTGPALQWVIPYIKKESPLLSDYRGFLAEMKRVFGWEEDEDF","sequence_length":113,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"17b4b74a43e121aa97602b2f3c227931c213ab2e9943c4d77ef795d950a29015","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q17RB0.json","taxon_id":"9606","uniprot_accession":"Q17RB0","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16297","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml"}],"pfam_ids":["PF16297"],"protein_name":"Retrotransposon Gag-like protein 6","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVQPRTSKTESPASAPGASAQMDDVVDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAITSNGTRPMTTPPTSLPEPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHSRRAQIRKTSASNRAVRERERERQMLCRQLAAAGTGSCPVHPASNGTNPAPALPSRGRNL","sequence_length":243,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"3250a98147530ad4676f773bd34f1d7f72a98a6f3ac98c064449fd48c1385b6c","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q505G4.json","taxon_id":"10090","uniprot_accession":"Q505G4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16297","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml"}],"pfam_ids":["PF16297","PF30901"],"protein_name":"Retrotransposon Gag-like protein 5","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSEAAGNLNSLRLANVALREELNALRGENVQLGLQLGRALAEVNSLRGNVSSYIRWPMPIVPVLAEENFEFLLNETDPTPEEEEEEEEEVPFLCWPPPRTDPEYVSDDLLINVVQDYTNPDGSSDPPLSPSPSQPELHSPMLKEPTFEFLLPPLERPDIEPFSGDPVYLAEFLMQLETFIADHEDHFPGGAERVAFLISFFTGEARDWAISVTQEGSSLHANFPRFLDEIRKEFCGPIPSRVAKKAIRKLKQGNCTLGSYADAFQFLAQFLSWDDCRLQNQFLKGLSEIFRKELLWSTEVADLDELILECVKIERKVRVPKTASLTGVQNSCCPFALIPNEDENEGVEFYSENEGEGEEAGGYRLYLKDQRQHMTAFPQEMREEEEEMRKEEDEMEDEEDEDEDEDYEFEEEDEDDDDEEEEEEEEEEEDKEEEMKNEDSDENKYEEEDEVIVRVLEPEQEQEREEIEHEHVYVHEHIHAHVHTLAAHHHGLHGELMVMDEPVLVDTSTQTISSAIGYHAENYLGVSPSVMHSSRQRSQNRVPLLEGLPGTNSSFYSPPPLMRHAGRLGQRQMRRCPSVLFCLTPRQGGHRATQGRIRV","sequence_length":599,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"813cb98b4b8e66f69379adc3f7b5b60100b23896f6309f6f9067ec97b50f3115","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q5DTT4.json","taxon_id":"10090","uniprot_accession":"Q5DTT4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16297","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml"}],"pfam_ids":["PF16297","PF30901"],"protein_name":"Retrotransposon Gag-like protein 5","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSEASGNLNSLRMANVALREELNALRGENANLGLQLGRALAEVNSLRGNVSSYIRWPVPIVPVLAEENLEFALSEIEVIPGGELPFLCRPPPRAEPDCISDDLLINVIQDRSTPDGPADPPLLPIPPPPALPPPASKEPPPQPPLAPLERPEIEPFSGDPVYLAEFLMQLETFIADHEVHFPGGAERVAFLISFFTGEAKDWAISVTQEGSPLHANFPRFLDEIRKEFCGPIPPRVAKKAIRKLKQGHCTLGSYADAFQFLAQFLSWDDCRLQNQFLKGLSEFFRKELLWSTEMADLDELILECVEIERKVRVPKPIPLPGVRNIIFPFAPSPNEEESEDEEYYSEDEDQEARRHRLHSKDQRKRMRAFQQEMKEKEEEEMKKEEEMKKKEEKEEEEEEEMKQKEEEEEIRNKNEEEGESKDEEDEDEDGGQKPEGEPQQDPGTEETYGEVEEEPLDEAQDDDLDELMEMEPTFVHASSQTSGPTSGYHAENFLGASPPIIQPSRRRNQNRVPLLEGLPGTNSPFYSSPQLIRRTGRLGQRQVRRRPPVLFRLTPRQGGHRAARGRIRV","sequence_length":569,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f77aee6af2a7d6c741d1335d303a794a3caf880b057aa441bf3ecd6b6d8ff0aa","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q5HYW3.json","taxon_id":"9606","uniprot_accession":"Q5HYW3","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16297","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml"}],"pfam_ids":["PF16297"],"protein_name":"Protein Bop","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MPRGRCRQQGPRIPIWAAANYANAHPWQQMDKASPGVAYTPLVDPWIERPCCGDTVCVRTTMEQKSTASGTCGGKPAERGPLAGHMPSSRPHRVDFCWVPGSDPGTFDGSPWLLDRFLAQLGDYMSFHFEHYQDNISRVCEILRRLTGRAQAWAAPYLDGDLPLPDDYELFCQDLKEVVQDPNSFAEYHAVVTCPLPLASSQLPVAPQLPVVRQYLARFLEGLALDMGTAPRSLPAAMATPAVSGSNSVSRSALFEQQLTKESTPGPKEPPVLPSSTCSSKPGPVEPASSQPEEAAPTPVPRLSESANPPAQRPDPAHPGGPKPQKTEEEVLETEGDQEVSLGTPQEVVEAPETPGEPPLSPGF","sequence_length":364,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c764aa32c46a1ccfe1b141080d228d2005b1592bdb15e8766fa38497ba336fc2","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7L3V2.json","taxon_id":"9606","uniprot_accession":"Q7L3V2","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/skeletal-muscle-satellite-cell-proliferation-go0014841.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0014841","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/skeletal-muscle-satellite-cell-proliferation-go0014841.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/retropepsins-pepsin-like-aspartate-proteases-the-family-includes-pepsi-cd00303.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd00303","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/retropepsins-pepsin-like-aspartate-proteases-the-family-includes-pepsi-cd00303.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/reverse-transcriptase-retrotransposon-derived-protein-rnase-h-like-dom-ipr041577.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR041577","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/reverse-transcriptase-retrotransposon-derived-protein-rnase-h-like-dom-ipr041577.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rt-rnaseh-2-pf17919.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF17919","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rt-rnaseh-2-pf17919.yaml"}],"pfam_ids":["PF16297","PF17919","PF30863","PF30901"],"protein_name":"Retrotransposon-like protein 1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MIEPSEDSFETMMELKNPSSKQMESSEGSSNTVEETPGSSGAQAGAQAGAQAEAQAETQVEAQAEAQAEAQVEAQVEAQAGSDSGPAQEEKEPPSGPLKEMQELPTNLLQEVEEPSSGPHQEMQELPTDLLQEVEEPSSGPHQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSGPYQEMQELPTDLLREVEEPSSDPCEASSNDLPQDMEESSDDGSNQESSDGSNHELSNGSNHESSFGSNPESSDVSNLESSGGSNQESSDGSQKESSYDSNPELSDNSNQELSDNSNQESSDSSNQSSDISNQEGSEPLSEASDYSMDETINSSETQSDQDDTDLGDDEEEEEEEGGEEEGQPKNSPEEVVATMGNVISLFLRMQDLKEQQRVAERLMMQAINEGRLPSLRPFSGDRRDYHEFVVLCQMTMQNYPSMLYNDELRVKFVIRHLTDLALEWANDLVEQNSPVINNFSAFLEAMSEKFEYRQTLRVAEDAMFNIRQGNRCAADYINEFRGLIPTLGWPDEVLQAHLCQGLNEEIRHYLFRIPQPNSLDNLIVLVLQLEEKLAERRALLRLPPESRPRSVAWMDAPAPEKWRVSSWLPNEFHPDIDRDHLFLLLLVRVDPYHSVAVRALVDSGAEGNYMDERFAQEHYVELYEKPYPQIIQGVDGIPIGNEPVWLCTEPLVCVHQKHYEYIEFDILPSPNFSIVLGMKWLRTHAPEVDWMRGRCTFHSPYCLRNCFTPPPPCIALETYSISLLPGLPHTYSDLADVFNPREADDETSDQPSSDGSDDLSESEPSELQQAGDSDQSGVFYESGARETLEPVSARMQEKARQQEKAREQEEYWILYDMLTDRQDYTQMVPELFDQLHGAAWFTKLELLGIKESEMRHTVTHTEDTWRASFGFGLHQMRCYRPFTMNSYSDEGNNIVHFILKDILGLFVICHGREVLVYSMSQEEHSQHVRQVLVRFRYHNIYCSLDKTQFHRQTAEILGFNISPKGVKLNKNLMNLIVGCPVPGSRRCLQSVIDLVYPYRHFVENFAVIAAPLVRQLLSSEPYYWGEEEQEALESLKRAFRKSPVLYHPKPQNPFYLETDITGSFLSASLVQTDDETGKKSTCAFYSRPLSTMEVEYPRVEMRILPIRAAFMVWCRYLENTEEPIMILLNTEDLASLNNDRLTVLLPGHWVFFFSHFNFGVMEMPAEGDTQALFRRCWNQRGFRARFLRPLLLMSIRANLRYFDRSSETEDKEDDEEEEEEDGEEEEGEEEEDGEEEEGEEEEDGEEEEEEEEDDEEEEGEEEEDGEEEEGEEEEDGEEEEGEEEEDGEEEEGEEEGEEEEEGEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEDEEEEDEEEEDEEVPSMVRELLAAIPMDHILNGLLAHFSVAQIRAVVLNFFRGLLYWKSLLGVAAVLVMLRARQPLSPVPAPNLEVARPQHRHTLRLILDSTLIASSGMATAIAQLLSQMPPLVGANTLPARELAELFLGPRCWHRNALHSQPPRGMRFTPGFWLTLCEFFGVRVNPEDDVFPDPYQHRYLELHVVGDEDVVLREALQDDLQRYRQCGLHDGLQDTSQDAQDNDVQEDLFGDQEAVTFRPRNLLDPEVLDFLNNRLLYTLGTDGRLTLLSRDQVAQALTRFLAMASRMALPSPAREQARLEELSDSDDELD","sequence_length":1744,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"be6369d0fc0af236143d8915371b3c4e93ec3c45d1f669ce810e16fb002b5bbf","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7M732.json","taxon_id":"10090","uniprot_accession":"Q7M732","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR032549","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/rtl1-3-8-ldoc-capsid-like-domain-ipr032549.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16297","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/rtl1-8-ldoc-pf16297.yaml"}],"pfam_ids":["PF16297"],"protein_name":"Protein LDOC1","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MVEELLSLLHALLDRHQALCMENHQLLKQLRLLVCERARLLRQVCPPSCPVPYPSRFSGESGRLPEFIMQTMSYMLANEEHFCNDAMKVAFLISLLSGEAEEWVMPYIESNSYVLGDYQAFVDEMKQYFGWGTDDEDDGDDDEEEEMEEDH","sequence_length":151,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"f71b03ca9b54b95cab77c705c336edf3ea4dfd66dcf4364ded23322ae670eccf","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q7TPY9.json","taxon_id":"10090","uniprot_accession":"Q7TPY9","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/function/pathway/go/vesicle-mediated-intercellular-transport-go0110077.yaml","qualification_status":"NOT_ASSESSED","record_id":"GO:0110077","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/function/pathway/go/vesicle-mediated-intercellular-transport-go0110077.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/cdd/retropepsins-pepsin-like-aspartate-proteases-the-family-includes-pepsi-cd00303.yaml","qualification_status":"NOT_ASSESSED","record_id":"CDD:cd00303","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/cdd/retropepsins-pepsin-like-aspartate-proteases-the-family-includes-pepsi-cd00303.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/homologous_superfamily/interpro/reverse-transcriptase-diguanylate-cyclase-domain-ipr043128.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR043128","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/homologous_superfamily/interpro/reverse-transcriptase-diguanylate-cyclase-domain-ipr043128.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/hiv-type-1-reverse-transcriptase-subunit-a-domain-1-3-10-10-10.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.10.10.10","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/hiv-type-1-reverse-transcriptase-subunit-a-domain-1-3-10-10-10.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/structure/homologous_superfamily/cath/reverse-transcriptase-diguanylate-cyclase-domain-3-30-70-270.yaml","qualification_status":"NOT_ASSESSED","record_id":"CATH:3.30.70.270","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/structure/homologous_superfamily/cath/reverse-transcriptase-diguanylate-cyclase-domain-3-30-70-270.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["ptm_registry_exact_uniprot_pfam_xref"],"mech":"ProteinTraitsMech","path":"data/grounding/protein_registry.jsonl","qualification_status":"NOT_ASSESSED_FOR_THIS_FAMILY","record_id":"UniProtKB:Q86TG7","section":"protein_registry","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"}],"pfam_ids":["PF16297","PF30863","PF30901"],"protein_name":"Retrotransposon-derived protein PEG10","registry_source":{"commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","path":"data/grounding/protein_registry.jsonl","repository":"https://github.com/CultureBotAI/proteintraitsmech","sequence_sha256":"4e861147e076019cba41912948ac55649a68a48f77a15eb0b193c74356612efe","sequence_version":2,"sha256":"1be0cf02b76b03a8fe9b80bcead9cd4a419157116eb8da038f266bcc33015eb9","uniprot_release":"2026_03","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/grounding/protein_registry.jsonl"},"registry_status":"EXACT_SEQUENCE_VERSION_MATCH","reviewed":true,"sequence":"MTERRRDELSEEINNLREKVMKQSEENNNLQSQVQKLTEENTTLREQVEPTPEDEDDDIELRGAAAAAAPPPPIEEECPEDLPEKFDGNPDMLAPFMAQCQIFMEKSTRDFSVDRVRVCFVTSMMTGRAARWASAKLERSHYLMHNYPAFMMEMKHVFEDPQRREVAKRKIRRLRQGMGSVIDYSNAFQMIAQDLDWNEPALIDQYHEGLSDHIQEELSHLEVAKSLSALIGQCIHIERRLARAAAARKPRSPPRALVLPHIASHHQVDPTEPVGGARMRLTQEEKERRRKLNLCLYCGTGGHYADNCPAKASKSSPAGKLPGPAVEGPSATGPEIIRSPQDDASSPHLQVMLQIHLPGRHTLFVRAMIDSGASGNFIDHEYVAQNGIPLRIKDWPILVEAIDGRPIASGPVVHETHDLIVDLGDHREVLSFDVTQSPFFPVVLGVRWLSTHDPNITWSTRSIVFDSEYCRYHCRMYSPIPPSLPPPAPQPPLYYPVDGYRVYQPVRYYYVQNVYTPVDEHVYPDHRLVDPHIEMIPGAHSIPSGHVYSLSEPEMAALRDFVARNVKDGLITPTIAPNGAQVLQVKRGWKLQVSYDCRAPNNFTIQNQYPRLSIPNLEDQAHLATYTEFVPQIPGYQTYPTYAAYPTYPVGFAWYPVGRDGQGRSLYVPVMITWNPHWYRQPPVPQYPPPQPPPPPPPPPPPPSYSTL","sequence_length":708,"sequence_origin":"PTM_REGISTRY_MIRROR","sequence_sha256":"4e861147e076019cba41912948ac55649a68a48f77a15eb0b193c74356612efe","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q86TG7.json","taxon_id":"9606","uniprot_accession":"Q86TG7","uniprot_release":"2026_03"}],"pfam_id":"PF16297","short_name":"RTL1-8_LDOC","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
