{"cross_mech":[],"family":{"alphafold_models":3216,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the six helical-hairpin domain found in homologues of Glutaminase A from Aspergillus oryzae. Glutaminase catalyzes the hydrolysis of glutamine to glutamic acid and plays a key role in nitrogen metabolism. It catalyzes the hydrolysis not only of L-glutamine but also of D-glutamine [[cite:PUB00035385]]. This domain share similarity with six-hairpin glycosidases.","domain_architectures":90,"interpro_id":"IPR032514","known_evidence_count":null,"matches":5628,"name":"Glutaminase A six helical-hairpin domain","partial_evidence_count":null,"pfam_id":"PF16335","proteins":4215,"proteomes":1856,"short_name":"GtaA_6_Hairpin","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16335","structures":0,"taxa":3600,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF16335.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3216,"domain_architectures":90,"matches":5628,"proteins":4215,"proteomes":1856,"structures":0,"taxa":3600},"curation_status":"SEEDED","description":"This entry represents the six helical-hairpin domain found in homologues of Glutaminase A from Aspergillus oryzae. Glutaminase catalyzes the hydrolysis of glutamine to glutamic acid and plays a key role in nitrogen metabolism. It catalyzes the hydrolysis not only of L-glutamine but also of D-glutamine [[cite:PUB00035385]]. This domain share similarity with six-hairpin glycosidases.","id":"Pfam:PF16335","interpro_id":"InterPro:IPR032514","name":"Glutaminase A six helical-hairpin 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glutaminase 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40)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/duf5127-pf17168.yaml","qualification_status":"NOT_ASSESSED","record_id":"Pfam:PF17168","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/duf5127-pf17168.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/repeat/pfam/gtaa-6-hairpin-pf16335.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF16335","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/repeat/pfam/gtaa-6-hairpin-pf16335.yaml"}],"pfam_ids":["PF16335","PF17168"],"protein_name":"Glutaminase 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