{"cross_mech":[],"family":{"alphafold_models":117,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the N-terminal disordered region of SMG1, which is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family. SMG1 associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay [[cite:PUB00085231]]. It also plays an important role in genotoxic stress responses to DNA damage [[cite:PUB00085233]].","domain_architectures":18,"interpro_id":"IPR035175","known_evidence_count":null,"matches":1093,"name":"Serine/threonine-protein kinase SMG1 N-terminal","partial_evidence_count":null,"pfam_id":"PF17229","proteins":1092,"proteomes":638,"short_name":"SMG1_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17229","structures":2,"taxa":2006,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF17229.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":117,"domain_architectures":18,"matches":1093,"proteins":1092,"proteomes":638,"structures":2,"taxa":2006},"curation_status":"SEEDED","description":"This entry represents the N-terminal disordered region of SMG1, which is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family. SMG1 associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay [[cite:PUB00085231]]. It also plays an important role in genotoxic stress responses to DNA damage [[cite:PUB00085233]].","id":"Pfam:PF17229","interpro_id":"InterPro:IPR035175","name":"Serine/threonine-protein kinase SMG1 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kinase 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