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Cocrystal structures of Cas6 from Methanococcus maripaludis (MmCas6b) bound with its repeat RNA revealed a dual-site binding structure and a cleavage site conformation poised for phosphodiester bond breakage [[cite:PUB00085376]].","id":"Pfam:PF17262","interpro_id":"InterPro:IPR020209","name":"Cas6b C-terminal domain","pfam_id":"PF17262","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"Cas6b_C","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17262"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF17262.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"e5ba47f65deb6d2f2c350f86d367b5f69edbb5852b7df2dfba1e92315776fec4"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/interpro/cas6b-c-terminal-domain-ipr020209.yaml","qualification_status":"NOT_ASSESSED","record_id":"InterPro:IPR020209","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/interpro/cas6b-c-terminal-domain-ipr020209.yaml"},{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/cas6b-c-pf17262.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF17262","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/cas6b-c-pf17262.yaml"}],"pfam_ids":["PF17262"],"protein_name":"Uncharacterized protein MJ0978","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MGEIILNIRELNLKGEVYRVVNGYAKVKFEEFGVAENMIKYKFISPWIALNEKNYLEYKELDEDGKKELLEKILVGNILSMSKYLDYTVEEKLKAGLLEYEDFVVKYKGNKFIGFWGEFLVNFNIPNYLGIGRKVSKGFGSVIRVEE","sequence_length":147,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"06f8ab7043bb03a686bfbe427c21e5802b0ea98ba5cc0e1e34fe1742734ced7b","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q58388.json","taxon_id":"243232","uniprot_accession":"Q58388","uniprot_release":"2026_03"}],"pfam_id":"PF17262","short_name":"Cas6b_C","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}