{"cross_mech":[],"family":{"alphafold_models":14,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This family represents histidine decarboxylase maturation protein HdcB, mainly found in Lactobacillus. HdcB performs a cleavage and modification of the pyruvoyl-dependent histidine decarboxylase HdcA, generating the pyruvoyl prosthetic group [[cite:PUB00099293]].","domain_architectures":1,"interpro_id":"IPR035227","known_evidence_count":null,"matches":21,"name":"Histidine decarboxylase maturation protein HdcB","partial_evidence_count":null,"pfam_id":"PF17528","proteins":21,"proteomes":15,"short_name":"HdcB","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17528","structures":0,"taxa":46,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF17528.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":14,"domain_architectures":1,"matches":21,"proteins":21,"proteomes":15,"structures":0,"taxa":46},"curation_status":"SEEDED","description":"This family represents histidine decarboxylase maturation protein HdcB, mainly found in Lactobacillus. HdcB performs a cleavage and modification of the pyruvoyl-dependent histidine decarboxylase HdcA, generating the pyruvoyl prosthetic group [[cite:PUB00099293]].","id":"Pfam:PF17528","interpro_id":"InterPro:IPR035227","name":"Histidine decarboxylase maturation protein HdcB","pfam_id":"PF17528","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"HdcB","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17528"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF17528.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"1e985a093c2b82a2abea97ae73d0ff7b5ac79ad9dbd5ff1c9a112574eb24a41a"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Lactobacillus sp. (strain 30a)","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/family/pfam/hdcb-pf17528.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF17528","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/family/pfam/hdcb-pf17528.yaml"}],"pfam_ids":["PF17528"],"protein_name":"Protein HdcB","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSNSNYQVSLERIKKVVPEELLTNALLAAIDNSGERMSQIIVDKKDNGNDYYLTIHRFFVYSNEEFTAFDKEDVADVEFVNGTPDGEVIITLKDGKVLHPSHICYGRAFDFIQDVKPKVITMAGYDSTIRGEFPQLLDPDHAEEIDRLRRWMQDGNISHYEYDDANPAYPKAGK","sequence_length":174,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"b0cd16981f0a279d2d388d76d17bf8ea669d1507516661f5428bb0ff06131e5f","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/P09111.json","taxon_id":"1593","uniprot_accession":"P09111","uniprot_release":"2026_03"}],"pfam_id":"PF17528","short_name":"HdcB","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
