{"cross_mech":[],"family":{"alphafold_models":534,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This entry represents the N-terminal domain of a family of proteins that includes RPA-related protein RADX from animals, the human member is also known as CXorf57. High-throughput sequencing used to identify genes driving tumorigenesis in Avian leukosis virus (ALV)-induced B-cell lymphomas, showed CXorf57 as the 10th most frequently targeted common integration site by ALV. ALV induces B-cell lymphoma and other neoplasms in chickens by integrating within or near cancer genes and perturbing their expression [[cite:PUB00138338]]. RADX is a replication factor A protein-like (RPA-like), single-stranded DNA binding protein recruited to replication forks to maintain genome stability [[cite:PUB00091321]]. It also modulates stalled fork protection by antagonising RAD51 [[cite:PUB00091322]]. These proteins consist of four tandem OB fold domains.","domain_architectures":23,"interpro_id":"IPR061920","known_evidence_count":null,"matches":615,"name":"RPA-related protein RADX N-terminal domain","partial_evidence_count":null,"pfam_id":"PF17659","proteins":614,"proteomes":402,"short_name":"RADX","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17659","structures":2,"taxa":1399,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF17659.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":534,"domain_architectures":23,"matches":615,"proteins":614,"proteomes":402,"structures":2,"taxa":1399},"curation_status":"SEEDED","description":"This entry represents the N-terminal domain of a family of proteins that includes RPA-related protein RADX from animals, the human member is also known as CXorf57. High-throughput sequencing used to identify genes driving tumorigenesis in Avian leukosis virus (ALV)-induced B-cell lymphomas, showed CXorf57 as the 10th most frequently targeted common integration site by ALV. ALV induces B-cell lymphoma and other neoplasms in chickens by integrating within or near cancer genes and perturbing their expression [[cite:PUB00138338]]. RADX is a replication factor A protein-like (RPA-like), single-stranded DNA binding protein recruited to replication forks to maintain genome stability [[cite:PUB00091321]]. It also modulates stalled fork protection by antagonising RAD51 [[cite:PUB00091322]]. These proteins consist of four tandem OB fold domains.","id":"Pfam:PF17659","interpro_id":"InterPro:IPR061920","name":"RPA-related protein RADX N-terminal domain","pfam_id":"PF17659","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"RADX","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17659"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF17659.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"9af23938f8d26a4581293610a05893649fc742f55297faf6c3979ac0fab01887"}},"protein_examples":{"candidate_count":2,"discovery_scanned":true,"example_count":2,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Homo sapiens","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/radx-pf17659.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF17659","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/radx-pf17659.yaml"}],"pfam_ids":["PF17659","PF31100","PF31101","PF31102"],"protein_name":"RPA-related protein RADX","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSGESGQPEAGPSHAGLDWPNPERNRAGVPGGVIRRAGSQGPRSWIQKVLEQIMDSPRQCVTPSEVVPVTVLAVQRYLLEDEPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNSLVYQNILKVGIQMRISRVSCLYNEKRIGQGILCIDNVHCGETSDSISLETPFRNRAHQEKPERPLRGGKSHYLALWNNEDPYGDIWLTDKQPEEHNFSDTKIISLSHLEMTWTNRRNFPALLVRILHKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKSLRVGLVLLLQDYSVKKSYPFRIQPVPVDPQIKLISTMEICLNLRDPPTNIIIIPEKQVKPEWRLPKLNHRFTTRSELDDMPENCICDVIGLLVFVGRVQRSKKKENREDFWSYRWIHIADGTSEQPFIVELFSTSQPEIFENIYPMAYFVCTQLKVVRNDNQVPKLLYLTTTNESGVFITGHRGQPYTYDAKVKNFIQWIRTKSDSGEQKNMVIGGYYPYPPVPETFSKYSSSIKVESLLTAISEVRKEIEDLQYREQKRIAIQGIITAIKYIPHSSATESASASETLRNANRPSTSQAARVEIQERNGKRHQDDEPVNSQYFQTTSTNLSLSNKIRILQGPHANPVAVPQPGASVQTKGIKPGMPSIFNRRANINANLQGKARKTISDRWESQLWREKKFGLIDHLHYSRVYPESIPRKFMFEHRKFLSDQYNSQPAKYVPPEGRPPKLDDFKSARSLGHFEVTILGLNHEIAIDVAFLPMYCPEDIRTSQIDTLLTSMNYSCAYPQDTTGNDRLPGPRAVAGDIIKAATELDRVHIVGILDICNLGNNKVEVYLHKIYSPENTS","sequence_length":855,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"c21d23e86576f585ef971e495afa16f143c9a61d51f9155de0b4e733f37a5c50","sequence_version":2,"source_url":"https://rest.uniprot.org/uniprotkb/Q6NSI4.json","taxon_id":"9606","uniprot_accession":"Q6NSI4","uniprot_release":"2026_03"},{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Mus musculus","origins":[{"cited_uniprot_accession":"","commit":"70edd6f8458845f7d7783ac4f416df519f5e1de6","link_basis":["canonical_example_family_classification","ptm_own_pfam_record_example"],"mech":"ProteinTraitsMech","path":"data/traits/sequence/domain/pfam/radx-pf17659.yaml","qualification_status":"LEGACY_OR_UNSPECIFIED","record_id":"Pfam:PF17659","section":"canonical_examples","url":"https://github.com/CultureBotAI/proteintraitsmech/blob/70edd6f8458845f7d7783ac4f416df519f5e1de6/data/traits/sequence/domain/pfam/radx-pf17659.yaml"}],"pfam_ids":["PF17659","PF31100","PF31101","PF31102"],"protein_name":"RPA-related protein RADX","registry_status":"NOT_IN_REGISTRY","reviewed":true,"sequence":"MSGESGQPQPGPSHAGLYLEHPERDQAGVPGGVIRRADSQRRRSWIQKVIEQITGSPRQCVTLSEVVPVTVLAVQRYLLEDEPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNFLVYQNILKVGIEMRISRVSCLYNEKRLGQGILCIDKVHCGESLDVISVETPFRNRAHEEKPERPLRGGKSHYLALWNNEDPYGDIWKTNKQPEEFNFNNIKIISLSHLELTWNSRKNFPALLVRVLHKSKLRYYGKPNKKMIEPYQTYLEVADSSGMVSVILWNALCPEWYKSLRVGLVLLLQDYTVKKSYPLRIQPDPADPQMKLISTMEICLNLRDPPTNIVIIPEKQLKSEWKLPKLINRFITRSELDDMPEKSICDVIGLLSFVGRVQRSKKKENSEDFWSYRWIHITDGTSEQPFIVQLFSTSQPEVFENIYPMTYFVCTQLKVVRNNSQVPKLLYLTTTNESRALTTGGHRGLPYTYDTKAKKIIQWIKTKTNLEAKNTVIGGYYPYPPVPETFSKYSRFIKAESLLTTISEVKKVIEDLQYREQKRIAIQGIITAIKYIPYKHSAGSAPAPEAFWNASRPSTSQAAGKEDHCHERGSKRSQDDRPMGSQHFQYTSKVLSLCAKRKILQGPSANPVPVPQPHSSAQMKGSKHNTPSQESSTAYTTGKSRRITNDRWESQLWQDKKFSLRDHLHYGHVDPESIPRKFILEHEKFLTQQFNSQPAKYIPPEGKPPKLDEFQSARSLGHFEVTILGLNHEIAIDVAFLPMYSPEDVQASQIDTFLTCMNFSCVYPPAAPLSGRLPDPKAVAGDIVKAAADLDRVHIIGILDICNLGNNKVEVCLQKIYTPE","sequence_length":850,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"71959593019efc0dedd797020c2542aa24661bb6ef31515b7a41beeb7508cdf1","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q8C779.json","taxon_id":"10090","uniprot_accession":"Q8C779","uniprot_release":"2026_03"}],"pfam_id":"PF17659","short_name":"RADX","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}