{"cross_mech":[],"family":{"alphafold_models":638,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"This is the N-terminal all helix domain found in N-acyltransferases (NATs), the gene products orf11 and dbv8. The all-helix domain is composed of eight helices with two helix-turn-helix motifs in tandem. It is structurally akin to the AAA+ protein family (ATPases associated with diverse cellular activities) [[cite:PUB00091662]].","domain_architectures":9,"interpro_id":"IPR041273","known_evidence_count":null,"matches":1090,"name":"N-acyltransferase N-terminal domain","partial_evidence_count":null,"pfam_id":"PF18082","proteins":1090,"proteomes":979,"short_name":"NAT_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF18082","structures":9,"taxa":1365,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF18082.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":638,"domain_architectures":9,"matches":1090,"proteins":1090,"proteomes":979,"structures":9,"taxa":1365},"curation_status":"SEEDED","description":"This is the N-terminal all helix domain found in N-acyltransferases (NATs), the gene products orf11 and dbv8. The all-helix domain is composed of eight helices with two helix-turn-helix motifs in tandem. It is structurally akin to the AAA+ protein family (ATPases associated with diverse cellular activities) [[cite:PUB00091662]].","id":"Pfam:PF18082","interpro_id":"InterPro:IPR041273","name":"N-acyltransferase N-terminal domain","pfam_id":"PF18082","provenance":{"generated_at":"2026-10-10T07:44:21.614711Z","path":"data/worklists/interpro-pfam-duf-2026-10-10.json","sha256":"17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383","snapshot_id":"interpro-pfam-duf-2026-10-10","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/"},"seed_status":"EX_DUF","short_name":"NAT_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF18082"},"source":{"commit":"c8155abfcf881ad8662936343deb81e604e3a194","path":"data/families/PF18082.yaml","repository":"https://github.com/CultureBotAI/DUFMech","sha256":"0abadc7d0093ec344a29a3aabc5697997f5147f79ca078eadaf1c10fffe665d2"}},"protein_examples":{"candidate_count":1,"discovery_scanned":true,"example_count":1,"examples":[{"evidence_scope":"FAMILY_MEMBERSHIP_NOT_FUNCTION","organism":"Actinoplanes teichomyceticus","origins":[{"cited_uniprot_accession":"Q70AY4","commit":"e66f934111777c4ebfe69475d0520c0cfa074785","link_basis":["uniprot_pfam_xref"],"mech":"NaturalProductMech","path":"data/natural_products/amino_acids_and_peptides/teicoplanin-a2-1.yaml","qualification_status":"NOT_ASSESSED","record_id":"naturalproductmech:mibig-77f24cb6bc","section":"uniprot_accession","url":"https://github.com/CultureBotAI/NaturalProductMech/blob/e66f934111777c4ebfe69475d0520c0cfa074785/data/natural_products/amino_acids_and_peptides/teicoplanin-a2-1.yaml"},{"cited_uniprot_accession":"Q70AY4","commit":"e66f934111777c4ebfe69475d0520c0cfa074785","link_basis":["uniprot_pfam_xref"],"mech":"NaturalProductMech","path":"data/natural_products/amino_acids_and_peptides/teicoplanin-a2-2.yaml","qualification_status":"NOT_ASSESSED","record_id":"CHEBI:85251","section":"uniprot_accession","url":"https://github.com/CultureBotAI/NaturalProductMech/blob/e66f934111777c4ebfe69475d0520c0cfa074785/data/natural_products/amino_acids_and_peptides/teicoplanin-a2-2.yaml"},{"cited_uniprot_accession":"Q70AY4","commit":"e66f934111777c4ebfe69475d0520c0cfa074785","link_basis":["uniprot_pfam_xref"],"mech":"NaturalProductMech","path":"data/natural_products/amino_acids_and_peptides/teicoplanin-a2-3.yaml","qualification_status":"NOT_ASSESSED","record_id":"CHEBI:34996","section":"uniprot_accession","url":"https://github.com/CultureBotAI/NaturalProductMech/blob/e66f934111777c4ebfe69475d0520c0cfa074785/data/natural_products/amino_acids_and_peptides/teicoplanin-a2-3.yaml"},{"cited_uniprot_accession":"Q70AY4","commit":"e66f934111777c4ebfe69475d0520c0cfa074785","link_basis":["uniprot_pfam_xref"],"mech":"NaturalProductMech","path":"data/natural_products/amino_acids_and_peptides/teicoplanin-a2-4.yaml","qualification_status":"NOT_ASSESSED","record_id":"CHEBI:34997","section":"uniprot_accession","url":"https://github.com/CultureBotAI/NaturalProductMech/blob/e66f934111777c4ebfe69475d0520c0cfa074785/data/natural_products/amino_acids_and_peptides/teicoplanin-a2-4.yaml"},{"cited_uniprot_accession":"Q70AY4","commit":"e66f934111777c4ebfe69475d0520c0cfa074785","link_basis":["uniprot_pfam_xref"],"mech":"NaturalProductMech","path":"data/natural_products/amino_acids_and_peptides/teicoplanin-a2-5.yaml","qualification_status":"NOT_ASSESSED","record_id":"naturalproductmech:mibig-3af27c73f8","section":"uniprot_accession","url":"https://github.com/CultureBotAI/NaturalProductMech/blob/e66f934111777c4ebfe69475d0520c0cfa074785/data/natural_products/amino_acids_and_peptides/teicoplanin-a2-5.yaml"}],"pfam_ids":["PF18082","PF18164"],"protein_name":"Acyltransferase","registry_status":"NOT_IN_REGISTRY","reviewed":false,"sequence":"MDPETVRIALGLEERTAAWLTELDELGPPAEPVRLPRGEEARDLLRRLEVPELDAEEIVAAAPDPDRDPALWWLLERTHHAIVRHMGDHRAKPRGGPPLPYEGGAAARYFHVYVFLATVPAVRRFHAERGIPDEVGWETLTQLGELVAIHRRKYGQGGMNMQWWTTYHLRGILYRLGRLQFSLATGKDGTPHLGLHVPEWGGPLLPKAYDESLHRARPFFDRHFPEHGARVAWGSSWMLDPQLEEYLTEDSNIIQLARFWTLTDSAPEPGNADGDSSILEFVFRYNGQPLDELPQRSSLERAVIAHLKAGRHWHMRTGFVKLP","sequence_length":323,"sequence_origin":"UNIPROT_FETCH","sequence_sha256":"1b89747e882ecf0b5b3bffde5683341c69d077c6c88972c117be1c0c2663d54a","sequence_version":1,"source_url":"https://rest.uniprot.org/uniprotkb/Q70AY4.json","taxon_id":"1867","uniprot_accession":"Q70AY4","uniprot_release":"2026_03"}],"pfam_id":"PF18082","short_name":"NAT_N","status":"HAS_SEQUENCE_EXAMPLE","unresolved":[]}}
