{"cross_mech":[],"family":{"alphafold_models":3031,"candidate_reasons":["pfam_previous_unknown_name"],"characterization_status":"","context_evidence_count":null,"cross_mech":{"example_proteins":0,"protein_traits_record":false,"records_by_mech":{},"scanned":false},"curation_status":"SEEDED","demotion_reasons":[],"description":"UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. Together with UPF2 and UPF3, forms a surveillance complex, in which UPF2 acts as a bridge between UPF1 and UPF3. UPF2 and UPF3 are non-enzymatic components of the complex that stimulate the activity of UPF1 [[cite:PUB00050141],[cite:PUB00095891]]. UPF1 has a N-terminal cysteine/histidine-rich zinc-binding domain (CH/ZBD), a regulatory 1B domain, followed by a helicase core that belongs to superfamily 1 (SF1). This entry represents 1B domain of UPF1 which has a regulatory role. It suffers conformational changes from an inhibitory state to a transition-state complex that modulate RNA binding [[cite:PUB00050141],[cite:PUB00095891]].","domain_architectures":89,"interpro_id":"IPR040812","known_evidence_count":null,"matches":3790,"name":"RNA helicase UPF1, 1B domain","partial_evidence_count":null,"pfam_id":"PF18141","proteins":3779,"proteomes":2612,"short_name":"UPF1_1B_dom","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF18141","structures":12,"taxa":7201,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF18141.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":3031,"domain_architectures":89,"matches":3790,"proteins":3779,"proteomes":2612,"structures":12,"taxa":7201},"curation_status":"SEEDED","description":"UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. Together with UPF2 and UPF3, forms a surveillance complex, in which UPF2 acts as a bridge between UPF1 and UPF3. UPF2 and UPF3 are non-enzymatic components of the complex that stimulate the activity of UPF1 [[cite:PUB00050141],[cite:PUB00095891]]. UPF1 has a N-terminal cysteine/histidine-rich zinc-binding domain (CH/ZBD), a regulatory 1B domain, followed by a helicase core that belongs to superfamily 1 (SF1). This entry represents 1B domain of UPF1 which has a regulatory role. It suffers conformational changes from an inhibitory state to a transition-state complex that modulate RNA binding [[cite:PUB00050141],[cite:PUB00095891]].","id":"Pfam:PF18141","interpro_id":"InterPro:IPR040812","name":"RNA helicase UPF1, 1B 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