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Proteins with this domain often also contain a C-terminal domain [pfam:PF14613].","domain_architectures":59,"interpro_id":"IPR045967","known_evidence_count":null,"matches":4050,"name":"HAM1-like, N-terminal domain","partial_evidence_count":null,"pfam_id":"PF19343","proteins":2939,"proteomes":1323,"short_name":"HAM1_N","source_url":"https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19343","structures":0,"taxa":2830,"unknown_status":"EX_DUF"},"inputs":{"cross_mech":"cross-mech-duf-examples-2026-10-10","members":"pfam-uniprot-uniref90-2026-10-07","protein_examples":"duf-protein-examples-2026-10-13","worklist":"interpro-pfam-duf-2026-10-10"},"members":[],"metadata":{"curation_status":"SEEDED","local_source":"source/data/families/PF19343.yaml","record":{"characterization_status":"UNSCORED","counters":{"alphafold_models":2413,"domain_architectures":59,"matches":4050,"proteins":2939,"proteomes":1323,"structures":0,"taxa":2830},"curation_status":"SEEDED","description":"This entry represents a domain found at the N-terminal end of the putative cell signalling protein HAM1 from Cryptococcus neoformans and similar fungal sequences. HAM1 may act as a negative regulator of mating during vegetative growth [[cite:PUB00155454]]. Proteins with this domain often also contain a C-terminal domain [pfam:PF14613].","id":"Pfam:PF19343","interpro_id":"InterPro:IPR045967","name":"HAM1-like, N-terminal 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